iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012579

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02056158

Gene Name

SOCS6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000017412.4	ENSBTAT00000023144.4	ENSBTAP00000023144.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.10e-17	62.3	398	445

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 398  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 445
           5788999********************888...***************997 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MKKISLKTFR KSFNLSKSKE DAEFMVVQQP ALAGDFGKEE SLFGSCYGKE MAGCELHGED 60
EKGGGGKNRA KSESLMGTLK RRLSAKQKAK GKGGAAAGGA ADEDTFSSSS APLVFKDARA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAAGA TCAGCCTTAA GACCTTCCGG AAATCTTTCA ATTTGAGTAA GAGCAAAGAA 60
GACGCAGAAT TCATGGTCGT ACAACAGCCA GCACTAGCCG GCGACTTTGG CAAAGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	95.22	5.00e-109	387.00
IUUC-Apl-004035	Anas platyrhynchos	94.20	7.00e-108	384.00
IUUC-Aca-004782	Anolis carolinensis	93.72	2.00e-106	379.00
IUUC-Ame-011790	Astyanax mexicanus	91.63	2.00e-100	359.00
IUUC-Bol-015843	Brassica oleracea	28.77	3.70e-02	32.70
IUUC-Cja-019528	Callithrix jacchus	95.17	5.00e-108	384.00
IUUC-Cfa-020678	Canis familiaris	95.22	5.00e-109	388.00
IUUC-Cpo-021947	Cavia porcellus	95.22	4.00e-109	388.00
IUUC-Csa-023935	Chlorocebus sabaeus	94.74	2.00e-108	385.00
IUUC-Cho-024477	Choloepus hoffmanni	92.82	6.00e-105	374.00
IUUC-Cin-025413	Ciona intestinalis	68.86	2.00e-65	242.00
IUUC-Csv-026247	Ciona savignyi	67.07	3.00e-64	239.00
IUUC-Dre-027636	Danio rerio	92.12	2.00e-101	362.00
IUUC-Dno-029048	Dasypus novemcinctus	95.22	1.00e-108	386.00
IUUC-Dor-030401	Dipodomys ordii	96.17	8.00e-110	390.00
IUUC-Ete-033116	Echinops telfairi	53.11	6.00e-46	177.00
IUUC-Eca-033825	Equus caballus	94.74	4.00e-108	385.00
IUUC-Fca-036253	Felis catus	95.65	2.00e-108	385.00
IUUC-Fal-037614	Ficedula albicollis	93.78	6.00e-108	384.00
IUUC-Fox-037898	Fusarium oxysporum	26.42	7.60e-01	27.30
IUUC-Gmo-038928	Gadus morhua	73.68	2.00e-98	352.00
IUUC-Gga-040177	Gallus gallus	94.20	7.00e-108	384.00
IUUC-Gac-042263	Gasterosteus aculeatus	90.64	4.00e-99	355.00
IUUC-Ggo-045288	Gorilla gorilla	94.74	2.00e-108	386.00
IUUC-Hsa-046409	Homo sapiens	94.74	2.00e-108	385.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	95.22	1.00e-108	387.00
IUUC-Lch-050354	Latimeria chalumnae	92.75	7.00e-104	370.00
IUUC-Loc-052319	Lepisosteus oculatus	91.30	1.00e-102	367.00
IUUC-Laf-054070	Loxodonta africana	95.22	3.00e-108	385.00
IUUC-Mcc-055045	Macaca mulatta	94.74	3.00e-108	385.00
IUUC-Meu-055917	Macropus eugenii	92.82	2.00e-107	382.00
IUUC-Mga-059273	Meleagris gallopavo	94.20	2.00e-107	383.00
IUUC-Mmr-061597	Microcebus murinus	95.17	3.00e-108	385.00
IUUC-Mdo-062492	Monodelphis domestica	46.40	4.00e-44	171.00
IUUC-Mmu-063374	Mus musculus	95.69	4.00e-109	388.00
IUUC-Mpu-065967	Mustela putorius furo	95.65	4.00e-108	385.00
IUUC-Mlu-067532	Myotis lucifugus	95.22	1.00e-108	387.00
IUUC-Nle-069373	Nomascus leucogenys	94.26	2.00e-107	382.00
IUUC-Opr-070873	Ochotona princeps	95.22	4.00e-118	418.00
IUUC-Ont-072498	Oreochromis niloticus	91.13	1.00e-100	360.00
IUUC-Oan-072943	Ornithorhynchus anatinus	63.18	2.00e-66	246.00
IUUC-Ocu-073870	Oryctolagus cuniculus	95.69	3.00e-109	388.00
IUUC-Ola-086866	Oryzias latipes	91.13	3.00e-99	354.00
IUUC-Oga-089057	Otolemur garnettii	95.17	4.00e-108	384.00
IUUC-Oar-090013	Ovis aries	82.92	2.00e-173	601.00
IUUC-Ptr-091054	Pan troglodytes	94.74	2.00e-108	386.00
IUUC-Pma-094253	Petromyzon marinus	75.69	3.00e-92	332.00
IUUC-Pfo-097179	Poecilia formosa	89.47	2.00e-100	359.00
IUUC-Pab-097702	Pongo abelii	94.74	2.00e-108	386.00
IUUC-Pca-100671	Procavia capensis	100.00	3.00e-82	298.00
IUUC-Rno-106044	Rattus norvegicus	95.69	4.00e-109	388.00
IUUC-Sha-107139	Sarcophilus harrisii	90.70	1.00e-82	300.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	3.60e-02	32.00
IUUC-Ssc-115343	Sus scrofa	96.14	4.00e-109	388.00
IUUC-Tgu-117061	Taeniopygia guttata	94.20	8.00e-108	384.00
IUUC-Tni-119829	Tetraodon nigroviridis	91.13	5.00e-100	358.00
IUUC-Ttr-129148	Tursiops truncatus	95.17	6.00e-108	384.00
IUUC-Vpa-130780	Vicugna pacos	96.14	1.00e-108	387.00
IUUC-Vvi-130966	Vitis vinifera	32.69	5.70e-02	31.20
IUUC-Xtr-132513	Xenopus tropicalis	89.86	4.00e-102	365.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence