iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046250

UUCD1 version

UUC-HoS-00207

Ensembl Protein ID

ENSP00000266643.5

UniProt Accession

Q86YJ5; B2R9U9; Q86VN5; Q96GG2; MARH9_HUMAN

Genbank Protein ID

BAG36646.1; EAW97065.1; AAH09489.1; AAH36455.2; AAH50397.1

Protein Name

E3 ubiquitin-protein ligase MARCH9; Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; RING finger protein 179; RING-type E3 ubiquitin transferase MARCH9

Genbank Nucleotide ID

AK313925; CH471054; BC009489; BC036455; BC050397

Gene Name

MARCH9; RNF179

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000139266.5	ENST00000266643.5	ENSP00000266643.5
ENSG00000139266.5	ENST00000548358.1	ENSP00000446758.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17604280; 17174307

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.081	15.1	110	155

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCg.....HvfhadClqkwpglknssskefrCPlC 45
           C iC++ +++g l+ pC      ++ h+ Cl +w     s++++++C lC
   Q: 110  CRICFQGPEQGELLSPCRcdgsvRCTHQPCLIRW----ISERGSWSCELC 155
           ********9998888885444556789*******....9*********** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MLKSRLRMFL NELKLLVLTG GGRPRAEPQP RGGRGGGCGW APFAGCSTRD GDGDEEEYYG 60
SEPRARGLAG DKEPRAGPLP PPAPPLPPPG ALDALSLSSS LDSGLRTPQC RICFQGPEQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGGAGCCG CCATTTGCCA CCGCCGAGCG CACGGGCCGA GCCAAGCCTG ATCCCGGAGC 60
CGGAGGGGGA CTGGGACCGA GAGAACGGCG ATGGGGGGCG GCCCCGCCGC AGGAGGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005795--C:Golgi stack
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005802--C:trans-Golgi network
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

hsa:92979

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000992	Aegilops tauschii	36.62	2.00e-08	52.80
IUUC-Aml-001373	Ailuropoda melanoleuca	95.78	9.00e-112	396.00
IUUC-Atr-002860	Amborella trichopoda	38.46	2.00e-08	53.10
IUUC-Aly-005700	Arabidopsis lyrata	35.62	9.00e-10	57.40
IUUC-Ath-007473	Arabidopsis thaliana	42.31	3.00e-09	56.20
IUUC-Ame-010820	Astyanax mexicanus	64.33	4.00e-117	414.00
IUUC-Bta-012719	Bos taurus	96.82	5.00e-125	440.00
IUUC-Bdi-014984	Brachypodium distachyon	42.31	2.00e-09	56.20
IUUC-Bol-015757	Brassica oleracea	34.25	8.00e-10	57.40
IUUC-Cja-019583	Callithrix jacchus	76.49	9.00e-113	400.00
IUUC-Cfa-020701	Canis familiaris	97.87	5.00e-115	406.00
IUUC-Cpo-021311	Cavia porcellus	96.73	3.00e-140	491.00
IUUC-Cre-022732	Chlamydomonas reinhardtii	40.38	3.00e-08	50.40
IUUC-Csa-023212	Chlorocebus sabaeus	87.04	1.00e-120	426.00
IUUC-Cho-024792	Choloepus hoffmanni	97.93	6.00e-119	420.00
IUUC-Cgl-026475	Colletotrichum gloeosporioides	34.07	5.00e-07	48.50
IUUC-Cne-027028	Cryptococcus neoformans	42.62	1.00e-08	54.70
IUUC-Dre-027921	Danio rerio	63.59	4.00e-122	431.00
IUUC-Dno-029652	Dasypus novemcinctus	96.82	1.00e-131	462.00
IUUC-Dor-030811	Dipodomys ordii	96.82	1.00e-130	459.00
IUUC-Ete-032298	Echinops telfairi	98.24	9.00e-110	389.00
IUUC-Eca-034077	Equus caballus	97.51	3.00e-119	421.00
IUUC-Eeu-035277	Erinaceus europaeus	96.04	4.00e-108	383.00
IUUC-Fca-035691	Felis catus	97.86	2.00e-114	404.00
IUUC-Fso-038329	Fusarium solani	34.09	5.00e-08	52.00
IUUC-Ggr-039944	Gaeumannomyces graminis	42.37	8.00e-09	54.70
IUUC-Gac-042171	Gasterosteus aculeatus	66.57	2.00e-109	388.00
IUUC-Ggo-044663	Gorilla gorilla	99.34	4.00e-127	447.00
IUUC-Hvu-047133	Hordeum vulgare	42.31	2.00e-09	56.20
IUUC-Itr-048606	Ictidomys tridecemlineatus	97.93	5.00e-112	397.00
IUUC-Lch-049563	Latimeria chalumnae	69.36	1.00e-115	409.00
IUUC-Lpe-051036	Leersia perrieri	32.91	1.00e-07	50.10
IUUC-Laf-054358	Loxodonta africana	97.11	1.00e-145	509.00
IUUC-Mcc-055132	Macaca mulatta	98.84	4.00e-134	471.00
IUUC-Meu-056776	Macropus eugenii	93.10	1.00e-110	392.00
IUUC-Mor-056968	Magnaporthe oryzae	37.50	7.00e-09	55.10
IUUC-Mpo-057421	Magnaporthe poae	42.37	1.00e-08	54.30
IUUC-Mmr-061668	Microcebus murinus	98.55	2.00e-133	468.00
IUUC-Mdo-062134	Monodelphis domestica	86.97	4.00e-122	431.00
IUUC-Mmu-063140	Mus musculus	95.11	8.00e-124	436.00
IUUC-Mpu-065878	Mustela putorius furo	98.34	3.00e-119	421.00
IUUC-Mlu-067572	Myotis lucifugus	90.07	1.00e-117	415.00
IUUC-Nle-068993	Nomascus leucogenys	98.53	5.00e-129	453.00
IUUC-Opr-071182	Ochotona princeps	96.11	6.00e-120	423.00
IUUC-Ont-071812	Oreochromis niloticus	64.17	7.00e-107	380.00
IUUC-Ocu-074117	Oryctolagus cuniculus	97.81	3.00e-110	390.00
IUUC-Oba-075487	Oryza barthii	40.00	3.00e-09	55.80
IUUC-Ogl-076942	Oryza glaberrima	32.91	6.00e-09	54.30
IUUC-Oin-079184	Oryza indica	32.91	5.00e-09	54.70
IUUC-Olo-080640	Oryza longistaminata	32.91	5.00e-09	54.30
IUUC-Oru-084407	Oryza rufipogon	32.91	5.00e-09	54.70
IUUC-Ola-087504	Oryzias latipes	64.35	2.00e-109	389.00
IUUC-Oga-088000	Otolemur garnettii	98.27	7.00e-133	466.00
IUUC-Oar-089364	Ovis aries	97.37	6.00e-103	366.00
IUUC-Ptr-090674	Pan troglodytes	99.42	1.00e-134	472.00
IUUC-Pan-092400	Papio anubis	98.84	1.00e-133	469.00
IUUC-Pma-094557	Petromyzon marinus	54.11	1.00e-66	246.00
IUUC-Pfo-097278	Poecilia formosa	67.04	3.00e-109	388.00
IUUC-Pab-098565	Pongo abelii	98.24	3.00e-110	390.00
IUUC-Pop-099515	Populus trichocarpa	36.84	3.00e-08	53.50
IUUC-Pca-100354	Procavia capensis	97.80	7.00e-110	390.00
IUUC-Pva-102716	Pteropus vampyrus	98.24	7.00e-110	389.00
IUUC-Rno-105711	Rattus norvegicus	92.15	6.00e-100	357.00
IUUC-Sha-106546	Sarcophilus harrisii	87.30	1.00e-126	445.00
IUUC-Ssl-108455	Sclerotinia sclerotiorum	28.71	1.00e-06	47.80
IUUC-Smo-109144	Selaginella moellendorffii	34.25	5.00e-10	57.40
IUUC-Sit-110567	Setaria italica	40.38	6.00e-09	54.70
IUUC-Sbi-114552	Sorghum bicolor	40.38	5.00e-09	54.70
IUUC-Tru-118357	Takifugu rubripes	65.63	8.00e-108	383.00
IUUC-Tni-120712	Tetraodon nigroviridis	63.92	5.00e-110	390.00
IUUC-Tca-121468	Theobroma cacao	39.22	2.00e-07	50.10
IUUC-Tvi-122666	Trichoderma virens	31.87	3.00e-08	52.80
IUUC-Tae-122991	Triticum aestivum	42.31	2.00e-09	56.20
IUUC-Tbe-128092	Tupaia belangeri	98.34	4.00e-120	424.00
IUUC-Ttr-128915	Tursiops truncatus	96.48	2.00e-101	361.00
IUUC-Vpa-130151	Vicugna pacos	98.24	2.00e-110	391.00
IUUC-Xtr-131868	Xenopus tropicalis	72.00	3.00e-113	401.00
IUUC-Xma-134247	Xiphophorus maculatus	67.80	9.00e-113	399.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence