iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047141

Ensembl Protein ID

MLOC_68196.1

UniProt Accession

F2CQD9; F2CQD9_HORVV

Genbank Protein ID

BAJ85060.1

Protein Name

Presenilin

Genbank Nucleotide ID

AK353841

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_68196	MLOC_68196.1	MLOC_68196.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	29.80	3.00e-30	129.00	IUUC-Cel-018553
UBD/Alpha-Helix/CUE	34.08	6.00e-23	106.00	IUUC-Dre-028689

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Hordeum vulgare

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MDPVADAPDP PGSAATVLDT LGEEVLAVMS PVSICMALVV LLITLLAPPS SPPSAPPPVT 60
AATLVYLESP SDSPAQKLVG ALLDAVVFIA LVAVVTFVLV ALYYYRCTGF LKNYMRFSAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTGCAGG GAACGCGTGA GAGTGAGTCC AACCAAACCC TCCGCCGACC GCCGTACCCG 60
TGCGCGTGCG AGACCGCCGC GGGGAGCGAG CGACCCAGGC CGAGATCGGG AAATTTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005798--C:Golgi-associated vesicle
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	96.67	0.00e+00	640.00
IUUC-Aml-001648	Ailuropoda melanoleuca	32.99	1.00e-33	135.00
IUUC-Atr-003039	Amborella trichopoda	53.66	1.00e-115	408.00
IUUC-Apl-003727	Anas platyrhynchos	30.84	2.00e-34	138.00
IUUC-Aca-004582	Anolis carolinensis	32.57	7.00e-36	143.00
IUUC-Aly-005455	Arabidopsis lyrata	48.82	2.00e-103	368.00
IUUC-Ath-006730	Arabidopsis thaliana	57.02	2.00e-63	234.00
IUUC-Ame-011500	Astyanax mexicanus	30.43	2.00e-31	128.00
IUUC-Bta-013026	Bos taurus	31.81	2.00e-34	139.00
IUUC-Bdi-014196	Brachypodium distachyon	83.33	1.00e-164	571.00
IUUC-Bol-015841	Brassica oleracea	51.10	4.00e-97	347.00
IUUC-Bra-017580	Brassica rapa	58.22	5.00e-46	177.00
IUUC-Cel-018553	Caenorhabditis elegans	31.06	3.00e-45	174.00
IUUC-Cja-019994	Callithrix jacchus	31.72	2.00e-33	135.00
IUUC-Cfa-020074	Canis familiaris	31.96	1.00e-34	139.00
IUUC-Cpo-022237	Cavia porcellus	31.96	4.00e-34	137.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	44.30	7.00e-49	187.00
IUUC-Csa-023537	Chlorocebus sabaeus	32.49	1.00e-33	135.00
IUUC-Cho-024735	Choloepus hoffmanni	33.75	9.00e-30	123.00
IUUC-Cin-025780	Ciona intestinalis	33.03	8.00e-46	176.00
IUUC-Csv-025967	Ciona savignyi	32.90	2.00e-27	115.00
IUUC-Cme-027341	Cyanidioschyzon merolae	41.94	3.20e+00	25.00
IUUC-Dre-028689	Danio rerio	31.22	3.00e-30	124.00
IUUC-Dno-029758	Dasypus novemcinctus	31.96	2.00e-33	135.00
IUUC-Dor-030609	Dipodomys ordii	54.32	4.00e-19	87.80
IUUC-Dme-031929	Drosophila melanogaster	36.82	1.00e-31	129.00
IUUC-Ete-032487	Echinops telfairi	60.49	7.00e-13	67.00
IUUC-Eca-033391	Equus caballus	29.69	1.00e-20	92.40
IUUC-Eeu-035134	Erinaceus europaeus	36.42	4.00e-32	130.00
IUUC-Fca-036243	Felis catus	32.95	4.00e-34	137.00
IUUC-Fal-036600	Ficedula albicollis	30.30	2.00e-35	142.00
IUUC-Gmo-039665	Gadus morhua	34.12	6.00e-23	100.00
IUUC-Gga-040993	Gallus gallus	30.75	2.00e-36	145.00
IUUC-Gac-042511	Gasterosteus aculeatus	32.03	6.00e-36	143.00
IUUC-Gma-043822	Glycine max	64.19	2.00e-45	175.00
IUUC-Ggo-045338	Gorilla gorilla	32.50	2.00e-31	128.00
IUUC-Hsa-046822	Homo sapiens	32.49	2.00e-33	135.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	35.26	3.00e-35	140.00
IUUC-Lch-049638	Latimeria chalumnae	32.27	3.00e-28	118.00
IUUC-Lpe-051132	Leersia perrieri	74.45	5.00e-137	479.00
IUUC-Loc-052469	Lepisosteus oculatus	30.63	6.00e-34	137.00
IUUC-Laf-053979	Loxodonta africana	33.11	5.00e-31	127.00
IUUC-Mcc-055682	Macaca mulatta	32.49	2.00e-33	135.00
IUUC-Meu-056004	Macropus eugenii	30.00	7.00e-21	93.60
IUUC-Mtr-058392	Medicago truncatula	53.56	1.00e-108	385.00
IUUC-Mga-059466	Meleagris gallopavo	31.59	1.00e-36	146.00
IUUC-Mmr-060890	Microcebus murinus	32.50	1.00e-31	129.00
IUUC-Mdo-062122	Monodelphis domestica	31.21	8.00e-33	133.00
IUUC-Mmu-063176	Mus musculus	31.67	1.00e-21	96.70
IUUC-Mac-064858	Musa acuminata	93.18	9.00e-44	169.00
IUUC-Mpu-065927	Mustela putorius furo	31.74	1.00e-34	139.00
IUUC-Mlu-067079	Myotis lucifugus	31.81	6.00e-40	157.00
IUUC-Nle-070180	Nomascus leucogenys	32.49	2.00e-33	135.00
IUUC-Opr-070344	Ochotona princeps	32.38	4.00e-30	124.00
IUUC-Ont-071846	Oreochromis niloticus	29.89	4.00e-33	134.00
IUUC-Oan-072783	Ornithorhynchus anatinus	35.80	9.00e-32	129.00
IUUC-Ocu-074527	Oryctolagus cuniculus	32.72	7.00e-34	137.00
IUUC-Oba-075256	Oryza barthii	78.93	2.00e-121	427.00
IUUC-Obr-076302	Oryza brachyantha	77.59	2.00e-140	490.00
IUUC-Ogl-077097	Oryza glaberrima	78.17	6.00e-138	482.00
IUUC-Ogu-078570	Oryza glumaepatula	79.90	2.00e-132	464.00
IUUC-Oin-079244	Oryza indica	77.95	2.00e-137	481.00
IUUC-Olo-080484	Oryza longistaminata	77.13	2.00e-90	324.00
IUUC-Ome-081814	Oryza meridionalis	79.52	3.00e-142	496.00
IUUC-Oni-082057	Oryza nivara	79.90	2.00e-132	464.00
IUUC-Opu-084176	Oryza punctata	80.15	4.00e-136	476.00
IUUC-Oru-084618	Oryza rufipogon	79.90	1.00e-132	464.00
IUUC-Osa-085602	Oryza sativa	79.80	4.00e-134	469.00
IUUC-Ola-086707	Oryzias latipes	32.42	1.00e-26	112.00
IUUC-Olu-087811	Ostreococcus lucimarinus	41.78	7.00e-45	172.00
IUUC-Oga-088560	Otolemur garnettii	32.84	5.00e-32	130.00
IUUC-Oar-090348	Ovis aries	31.35	3.00e-35	141.00
IUUC-Ptr-091060	Pan troglodytes	32.49	2.00e-33	135.00
IUUC-Pan-091742	Papio anubis	32.50	1.00e-31	129.00
IUUC-Psi-093505	Pelodiscus sinensis	30.91	4.00e-36	144.00
IUUC-Pma-094612	Petromyzon marinus	31.62	7.00e-24	103.00
IUUC-Ppa-095431	Physcomitrella patens	44.10	2.00e-91	328.00
IUUC-Pfo-097396	Poecilia formosa	32.21	1.00e-40	159.00
IUUC-Pab-098591	Pongo abelii	32.49	2.00e-33	135.00
IUUC-Pop-099661	Populus trichocarpa	46.41	9.00e-88	315.00
IUUC-Pca-101029	Procavia capensis	34.57	5.00e-29	120.00
IUUC-Ppe-101495	Prunus persica	53.68	1.00e-114	404.00
IUUC-Pva-102934	Pteropus vampyrus	31.00	4.00e-29	121.00
IUUC-Rno-105861	Rattus norvegicus	32.27	1.00e-21	96.30
IUUC-Sha-107045	Sarcophilus harrisii	31.72	2.00e-33	135.00
IUUC-Smo-109325	Selaginella moellendorffii	48.67	5.00e-38	150.00
IUUC-Sit-110624	Setaria italica	76.24	4.00e-136	476.00
IUUC-Sly-110865	Solanum lycopersicum	88.57	2.00e-33	132.00
IUUC-Stu-112433	Solanum tuberosum	56.07	2.00e-106	377.00
IUUC-Sar-113169	Sorex araneus	42.06	1.00e-19	89.70
IUUC-Sbi-114305	Sorghum bicolor	75.65	1.00e-139	488.00
IUUC-Ssc-115766	Sus scrofa	31.75	4.00e-33	134.00
IUUC-Tgu-116469	Taeniopygia guttata	31.65	3.00e-33	134.00
IUUC-Tru-117732	Takifugu rubripes	30.77	9.00e-36	143.00
IUUC-Tsy-119303	Tarsius syrichta	43.04	5.00e-06	44.30
IUUC-Tni-119852	Tetraodon nigroviridis	30.58	4.00e-33	134.00
IUUC-Tca-121865	Theobroma cacao	53.15	8.00e-109	385.00
IUUC-Tae-123984	Triticum aestivum	96.74	0.00e+00	662.00
IUUC-Tur-126237	Triticum urartu	97.21	8.00e-165	572.00
IUUC-Tbe-127632	Tupaia belangeri	32.50	2.00e-31	128.00
IUUC-Ttr-128793	Tursiops truncatus	31.19	2.00e-30	125.00
IUUC-Vpa-130625	Vicugna pacos	40.95	1.00e-18	86.70
IUUC-Vvi-131312	Vitis vinifera	53.58	2.00e-107	381.00
IUUC-Xtr-132756	Xenopus tropicalis	32.04	5.00e-38	150.00
IUUC-Xma-133377	Xiphophorus maculatus	30.86	4.00e-37	147.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence