iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088789

Ensembl Protein ID

ENSOGAP00000003496.2

UniProt Accession

H0WNS4; H0WNS4_OTOGA

Genbank Protein ID

ENSOGAP00000003496

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAQR03003921

Gene Name

FYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000003928.2	ENSOGAT00000003931.2	ENSOGAP00000003496.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-15	56.2	87	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++ +++W+++ + ++g  G +P+n+v+ ++
   Q: 87   FVALYDYEARTEDDLSFHKGEKFQIL--NSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
           789***********************..89999*********************9987 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATTTAGAT AATGGGCTGT GTGCAATGTA AGGATAAAGA AGCAACAAAA CTGACGGAGG 60
AGCGGGACGG CAGCCTGAAC CAGAGCTCCG GGTACCGCTA TGGCACAGAC CCCACCCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004871--F:signal transducer activity
GO:0050798--P:activated T cell proliferation
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0048813--P:dendrite morphogenesis
GO:0050966--P:detection of mechanical stimulus involved in sensory perception of pain
GO:0030900--P:forebrain development
GO:1902951--P:negative regulation of dendritic spine maintenance
GO:0010629--P:negative regulation of gene expression
GO:0042177--P:negative regulation of protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001764--P:neuron migration
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901216--P:positive regulation of neuron death
GO:0010976--P:positive regulation of neuron projection development
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0090314--P:positive regulation of protein targeting to membrane
GO:0042523--P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777--P:protein autophosphorylation
GO:1905664--P:regulation of calcium ion import across plasma membrane
GO:0008360--P:regulation of cell shape
GO:1904645--P:response to beta-amyloid
GO:0045471--P:response to ethanol
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	94.23	0.00e+00	1017.00
IUUC-Apl-003716	Anas platyrhynchos	97.39	0.00e+00	1055.00
IUUC-Aca-005065	Anolis carolinensis	93.30	0.00e+00	1006.00
IUUC-Ame-011876	Astyanax mexicanus	83.09	0.00e+00	884.00
IUUC-Bta-012645	Bos taurus	94.04	0.00e+00	1015.00
IUUC-Cja-019027	Callithrix jacchus	94.23	0.00e+00	1017.00
IUUC-Cfa-021163	Canis familiaris	94.23	0.00e+00	1017.00
IUUC-Cpo-022315	Cavia porcellus	94.23	0.00e+00	1017.00
IUUC-Csa-023721	Chlorocebus sabaeus	94.04	0.00e+00	1015.00
IUUC-Cho-025014	Choloepus hoffmanni	94.04	0.00e+00	1015.00
IUUC-Dre-027985	Danio rerio	86.96	0.00e+00	982.00
IUUC-Dno-030043	Dasypus novemcinctus	88.62	0.00e+00	1027.00
IUUC-Dor-031035	Dipodomys ordii	92.92	0.00e+00	998.00
IUUC-Dme-031976	Drosophila melanogaster	60.22	8.00e-161	560.00
IUUC-Eeu-034582	Erinaceus europaeus	90.49	6.00e-177	613.00
IUUC-Fca-035582	Felis catus	94.23	0.00e+00	1017.00
IUUC-Fal-037320	Ficedula albicollis	97.75	0.00e+00	1060.00
IUUC-Gmo-038992	Gadus morhua	85.53	0.00e+00	962.00
IUUC-Gga-041262	Gallus gallus	97.75	0.00e+00	1060.00
IUUC-Gac-042461	Gasterosteus aculeatus	84.92	0.00e+00	961.00
IUUC-Ggo-044469	Gorilla gorilla	93.12	0.00e+00	1011.00
IUUC-Hsa-045723	Homo sapiens	94.04	0.00e+00	1015.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	94.23	0.00e+00	1017.00
IUUC-Lch-049825	Latimeria chalumnae	87.15	0.00e+00	939.00
IUUC-Loc-052531	Lepisosteus oculatus	85.85	0.00e+00	971.00
IUUC-Laf-053659	Loxodonta africana	94.04	0.00e+00	1015.00
IUUC-Mcc-055039	Macaca mulatta	97.59	0.00e+00	1059.00
IUUC-Mga-060067	Meleagris gallopavo	93.12	0.00e+00	1005.00
IUUC-Mmr-061194	Microcebus murinus	94.23	0.00e+00	1017.00
IUUC-Mdo-062628	Monodelphis domestica	94.04	0.00e+00	1016.00
IUUC-Mmu-063896	Mus musculus	93.85	0.00e+00	1014.00
IUUC-Mpu-066333	Mustela putorius furo	93.85	0.00e+00	1013.00
IUUC-Mlu-067315	Myotis lucifugus	94.23	0.00e+00	1017.00
IUUC-Nle-068978	Nomascus leucogenys	98.69	0.00e+00	1066.00
IUUC-Ont-072516	Oreochromis niloticus	86.22	0.00e+00	975.00
IUUC-Oan-073714	Ornithorhynchus anatinus	92.97	0.00e+00	875.00
IUUC-Ocu-074284	Oryctolagus cuniculus	94.04	0.00e+00	1015.00
IUUC-Ola-087431	Oryzias latipes	86.27	0.00e+00	972.00
IUUC-Oar-089408	Ovis aries	94.04	0.00e+00	1015.00
IUUC-Ptr-091068	Pan troglodytes	94.04	0.00e+00	1015.00
IUUC-Pan-092217	Papio anubis	94.04	0.00e+00	1015.00
IUUC-Psi-093602	Pelodiscus sinensis	93.11	0.00e+00	1006.00
IUUC-Pfo-097084	Poecilia formosa	86.59	0.00e+00	978.00
IUUC-Pab-097673	Pongo abelii	93.67	0.00e+00	1011.00
IUUC-Pca-100245	Procavia capensis	91.36	0.00e+00	899.00
IUUC-Pva-102645	Pteropus vampyrus	92.35	0.00e+00	979.00
IUUC-Rno-105372	Rattus norvegicus	94.04	0.00e+00	1016.00
IUUC-Sha-107637	Sarcophilus harrisii	93.67	0.00e+00	1002.00
IUUC-Sar-113016	Sorex araneus	82.87	0.00e+00	871.00
IUUC-Ssc-116389	Sus scrofa	93.85	0.00e+00	1010.00
IUUC-Tgu-117206	Taeniopygia guttata	97.75	0.00e+00	1060.00
IUUC-Tru-118241	Takifugu rubripes	85.40	0.00e+00	968.00
IUUC-Tni-120031	Tetraodon nigroviridis	86.03	0.00e+00	967.00
IUUC-Tbe-127707	Tupaia belangeri	90.65	0.00e+00	897.00
IUUC-Ttr-129145	Tursiops truncatus	94.23	0.00e+00	1017.00
IUUC-Vpa-130815	Vicugna pacos	91.39	0.00e+00	961.00
IUUC-Xtr-132293	Xenopus tropicalis	94.94	0.00e+00	1033.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence