iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022019

Ensembl Protein ID

ENSCPOP00000019336.1

UniProt Accession

H0W8M9; H0W8M9_CAVPO

Genbank Protein ID

ENSCPOP00000019336

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02047351

Gene Name

HGS

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000020715.1	ENSCPOT00000021567.1	ENSCPOP00000019336.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/VHS	2.20e-51	173.3	15	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel+ellk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGACGAG GGAGCGGCAC CTTCGAGCGT CTCCTAGGTA ACATGCCACG CAGGGCCAGC 60
AGTCTGGCTG CTCACTTTTC TTCCCGGCGC GACCTCCGGG CCCTCGGGGA ACAGTCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	86.13	0.00e+00	999.00
IUUC-Apl-003662	Anas platyrhynchos	81.21	0.00e+00	977.00
IUUC-Aca-004940	Anolis carolinensis	83.18	0.00e+00	1148.00
IUUC-Ago-007931	Ashbya gossypii	30.33	7.00e-27	115.00
IUUC-Acl-008274	Aspergillus clavatus	30.93	6.00e-40	159.00
IUUC-Afl-008521	Aspergillus flavus	33.94	6.00e-41	162.00
IUUC-Afu-008774	Aspergillus fumigatus	32.59	1.00e-40	161.00
IUUC-Ani-009445	Aspergillus nidulans	32.59	4.00e-41	162.00
IUUC-Ang-009863	Aspergillus niger	33.21	2.00e-42	167.00
IUUC-Ate-010444	Aspergillus terreus	34.46	5.00e-43	169.00
IUUC-Ame-011111	Astyanax mexicanus	77.02	0.00e+00	939.00
IUUC-Bgr-012087	Blumeria graminis	34.15	4.00e-43	169.00
IUUC-Bta-012506	Bos taurus	91.35	0.00e+00	1181.00
IUUC-Bci-013782	Botrytis cinerea	31.45	3.00e-42	167.00
IUUC-Cel-018493	Caenorhabditis elegans	52.61	3.00e-68	253.00
IUUC-Cja-019998	Callithrix jacchus	89.87	0.00e+00	1099.00
IUUC-Cfa-020615	Canis familiaris	87.76	0.00e+00	1083.00
IUUC-Csa-023596	Chlorocebus sabaeus	91.53	0.00e+00	1103.00
IUUC-Cin-025488	Ciona intestinalis	47.24	2.00e-128	453.00
IUUC-Csv-025802	Ciona savignyi	49.54	4.00e-115	408.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	35.76	5.00e-41	162.00
IUUC-Cne-026847	Cryptococcus neoformans	31.60	2.00e-38	154.00
IUUC-Dre-028353	Danio rerio	75.27	0.00e+00	924.00
IUUC-Dno-029005	Dasypus novemcinctus	85.86	0.00e+00	1132.00
IUUC-Dor-030280	Dipodomys ordii	90.92	0.00e+00	1171.00
IUUC-Dse-031238	Dothistroma septosporum	38.71	5.00e-43	169.00
IUUC-Dme-031952	Drosophila melanogaster	45.79	3.00e-98	352.00
IUUC-Ete-032235	Echinops telfairi	97.27	2.00e-133	469.00
IUUC-Eca-033873	Equus caballus	91.69	0.00e+00	1156.00
IUUC-Eeu-034652	Erinaceus europaeus	96.65	1.00e-105	377.00
IUUC-Fca-036563	Felis catus	89.50	0.00e+00	1129.00
IUUC-Fal-036649	Ficedula albicollis	82.75	0.00e+00	1022.00
IUUC-Fox-037962	Fusarium oxysporum	33.83	2.00e-40	160.00
IUUC-Fso-038396	Fusarium solani	34.07	1.00e-40	161.00
IUUC-Gmo-039510	Gadus morhua	74.08	0.00e+00	964.00
IUUC-Ggr-039938	Gaeumannomyces graminis	32.51	1.00e-37	151.00
IUUC-Gga-040201	Gallus gallus	82.35	0.00e+00	1113.00
IUUC-Gac-041459	Gasterosteus aculeatus	73.78	0.00e+00	969.00
IUUC-Ggo-044573	Gorilla gorilla	92.68	0.00e+00	1192.00
IUUC-Hsa-046009	Homo sapiens	92.81	0.00e+00	1238.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	93.58	0.00e+00	1255.00
IUUC-Kpa-049327	Komagataella pastoris	31.42	2.00e-33	137.00
IUUC-Lch-049944	Latimeria chalumnae	74.89	2.00e-154	538.00
IUUC-Loc-051850	Lepisosteus oculatus	78.35	0.00e+00	1011.00
IUUC-Lma-053252	Leptosphaeria maculans	35.65	2.00e-41	164.00
IUUC-Laf-053346	Loxodonta africana	82.99	0.00e+00	1042.00
IUUC-Mcc-055789	Macaca mulatta	92.29	0.00e+00	1172.00
IUUC-Meu-056329	Macropus eugenii	71.15	2.00e-157	549.00
IUUC-Mor-057205	Magnaporthe oryzae	33.56	6.00e-39	155.00
IUUC-Mpo-057295	Magnaporthe poae	32.87	1.00e-39	158.00
IUUC-Mla-058849	Melampsora laricipopulina	32.90	1.00e-32	134.00
IUUC-Mga-059361	Meleagris gallopavo	81.97	0.00e+00	1040.00
IUUC-Mvi-060561	Microbotryum violaceum	32.40	7.00e-40	158.00
IUUC-Mmr-061122	Microcebus murinus	94.25	0.00e+00	1031.00
IUUC-Mdo-062171	Monodelphis domestica	88.63	0.00e+00	1186.00
IUUC-Mmu-063952	Mus musculus	92.03	0.00e+00	1292.00
IUUC-Mpu-065852	Mustela putorius furo	89.39	0.00e+00	1097.00
IUUC-Mlu-066996	Myotis lucifugus	82.30	3.00e-147	514.00
IUUC-Nfi-068539	Neosartorya fischeri	32.59	7.00e-41	162.00
IUUC-Ncr-068726	Neurospora crassa	39.19	4.00e-40	159.00
IUUC-Nle-070148	Nomascus leucogenys	86.91	0.00e+00	1064.00
IUUC-Opr-070833	Ochotona princeps	73.10	0.00e+00	804.00
IUUC-Ont-071261	Oreochromis niloticus	77.06	0.00e+00	972.00
IUUC-Oan-073684	Ornithorhynchus anatinus	70.75	3.00e-159	554.00
IUUC-Ola-087570	Oryzias latipes	75.03	0.00e+00	984.00
IUUC-Oga-089087	Otolemur garnettii	87.88	0.00e+00	1075.00
IUUC-Oar-089534	Ovis aries	91.35	0.00e+00	1180.00
IUUC-Ptr-091654	Pan troglodytes	87.29	0.00e+00	1082.00
IUUC-Pan-092652	Papio anubis	91.78	0.00e+00	1172.00
IUUC-Pno-095125	Phaeosphaeria nodorum	38.53	1.00e-42	167.00
IUUC-Pfo-096757	Poecilia formosa	75.68	0.00e+00	943.00
IUUC-Pab-097788	Pongo abelii	95.07	0.00e+00	835.00
IUUC-Pca-100145	Procavia capensis	77.89	0.00e+00	908.00
IUUC-Pva-102965	Pteropus vampyrus	86.54	0.00e+00	1099.00
IUUC-Pgr-103609	Puccinia graminis	34.69	7.00e-34	138.00
IUUC-Ptt-103865	Puccinia triticina	35.71	1.00e-34	141.00
IUUC-Pte-104095	Pyrenophora teres	35.24	3.00e-42	166.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	35.87	1.00e-41	165.00
IUUC-Rno-105125	Rattus norvegicus	93.11	0.00e+00	1201.00
IUUC-Sce-106192	Saccharomyces cerevisiae	28.00	5.00e-27	115.00
IUUC-Sha-107066	Sarcophilus harrisii	88.92	0.00e+00	1139.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	34.46	5.00e-42	166.00
IUUC-Spo-108220	Schizosaccharomyces pombe	35.65	4.00e-37	149.00
IUUC-Stu-112464	Solanum tuberosum	45.90	1.00e-13	72.00
IUUC-Sar-113393	Sorex araneus	92.11	7.00e-107	381.00
IUUC-Sre-114986	Sporisorium reilianum	38.12	1.00e-42	167.00
IUUC-Tgu-117505	Taeniopygia guttata	81.66	0.00e+00	1048.00
IUUC-Tru-118494	Takifugu rubripes	77.22	0.00e+00	1004.00
IUUC-Tsy-119626	Tarsius syrichta	98.97	7.00e-54	205.00
IUUC-Tni-120174	Tetraodon nigroviridis	73.87	0.00e+00	1003.00
IUUC-Tre-122191	Trichoderma reesei	34.18	2.00e-41	164.00
IUUC-Tvi-122318	Trichoderma virens	33.68	2.00e-42	167.00
IUUC-Tme-126914	Tuber melanosporum	34.75	2.00e-44	173.00
IUUC-Ttr-129095	Tursiops truncatus	91.63	0.00e+00	1205.00
IUUC-Uma-129475	Ustilago maydis	36.61	2.00e-39	157.00
IUUC-Vda-129908	Verticillium dahliae	33.57	1.00e-36	147.00
IUUC-Xtr-131900	Xenopus tropicalis	75.97	0.00e+00	1051.00
IUUC-Xma-133124	Xiphophorus maculatus	75.78	0.00e+00	981.00
IUUC-Yli-134682	Yarrowia lipolytica	35.78	5.00e-33	135.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence