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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045783
UUCD1 version UUC-HoS-00288
Ensembl Protein ID ENSP00000330221.6
UniProt Accession Q96BD6; A2A275; Q59FA1; Q5TIH9; Q9BRY9; Q9H6C5; SPSB1_HUMAN
Genbank Protein ID AAL57345.1; BAB15335.1; BAD92796.1; CAI14376.2; CAI14376.2; CAM12843.1; CAM12843.1; EAW71617.1; AAH05852.2; AAH15711.1
Protein Name SPRY domain-containing SOCS box protein 1
Genbank Nucleotide ID AF403026; AK026046; AB209559; AL358252; AL008734; AL008734; AL358252; CH471130; BC005852; BC015711
Gene Name SPSB1; SSB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000171621.13 ENST00000328089.10 ENSP00000330221.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMIC
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 21199876; 11384984
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 2.70e-15 57.6 230 273
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           l  ep +L++LCR+++r +lg++rl +i++LPLP sLk YLly+
   Q: 230  LDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ 273
           5679***************************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND 60
RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045783|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTTTTTCTC CTCCGCACAG AAGTCGCGCT CGGGCAGCCT GCGCGCTCGC AGCAGGAACC 60
AGGCTCCAGG CGCCGGCGCC GGGGCCGGGG CCGCGGGGAG GAGGCGACTT CGCTCCCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045783|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50225--SOCS
Pfam

PF07525--SOCS_box
PF00622--SPRY
SMART

SM00969--SOCS_box
SM00449--SPRY
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
GO:0000209--P:protein polyubiquitination
KEGG hsa:80176
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002040 Ailuropoda melanoleuca 97.80 1.00e-159 555.00
IUUC-Apl-004008 Anas platyrhynchos 95.97 2.00e-156 544.00
IUUC-Aca-004631 Anolis carolinensis 91.58 2.00e-151 528.00
IUUC-Aly-006295 Arabidopsis lyrata 24.27 1.70e-01 31.20
IUUC-Ame-010841 Astyanax mexicanus 86.45 1.00e-144 504.00
IUUC-Bta-012816 Bos taurus 98.53 9.00e-161 558.00
IUUC-Cja-019531 Callithrix jacchus 99.63 3.00e-162 563.00
IUUC-Cfa-020107 Canis familiaris 98.90 1.00e-161 561.00
IUUC-Cpo-021983 Cavia porcellus 98.53 6.00e-160 556.00
IUUC-Csa-023603 Chlorocebus sabaeus 99.27 4.00e-162 563.00
IUUC-Cin-025737 Ciona intestinalis 60.48 8.00e-94 337.00
IUUC-Csv-026238 Ciona savignyi 58.80 3.00e-90 324.00
IUUC-Dre-028699 Danio rerio 87.18 2.00e-145 508.00
IUUC-Dno-028959 Dasypus novemcinctus 98.84 2.00e-153 535.00
IUUC-Dor-030400 Dipodomys ordii 98.17 1.00e-159 555.00
IUUC-Dme-031730 Drosophila melanogaster 70.40 5.00e-116 410.00
IUUC-Eca-034017 Equus caballus 99.27 9.00e-162 562.00
IUUC-Eeu-035331 Erinaceus europaeus 97.44 2.00e-158 551.00
IUUC-Fca-035981 Felis catus 98.90 1.00e-161 561.00
IUUC-Fal-037253 Ficedula albicollis 92.31 2.00e-151 528.00
IUUC-Fox-037964 Fusarium oxysporum 34.48 1.00e-02 35.40
IUUC-Gmo-038813 Gadus morhua 78.75 2.00e-132 464.00
IUUC-Gga-040286 Gallus gallus 95.60 3.00e-155 540.00
IUUC-Gac-041392 Gasterosteus aculeatus 81.68 3.00e-137 481.00
IUUC-Ggo-044990 Gorilla gorilla 99.63 3.00e-162 563.00
IUUC-Itr-048565 Ictidomys tridecemlineatus 99.60 1.00e-150 525.00
IUUC-Lch-049583 Latimeria chalumnae 87.91 6.00e-140 489.00
IUUC-Loc-052220 Lepisosteus oculatus 86.45 2.00e-143 501.00
IUUC-Laf-053976 Loxodonta africana 98.44 5.00e-151 526.00
IUUC-Mcc-055223 Macaca mulatta 99.63 3.00e-162 563.00
IUUC-Meu-056426 Macropus eugenii 98.53 2.00e-160 558.00
IUUC-Mga-059620 Meleagris gallopavo 95.60 3.00e-155 540.00
IUUC-Mmr-061373 Microcebus murinus 98.17 6.00e-160 556.00
IUUC-Mdo-063064 Monodelphis domestica 98.17 6.00e-160 556.00
IUUC-Mmu-064370 Mus musculus 98.53 6.00e-160 556.00
IUUC-Mpu-066516 Mustela putorius furo 98.53 7.00e-161 559.00
IUUC-Opr-070732 Ochotona princeps 97.07 9.00e-158 549.00
IUUC-Ont-071692 Oreochromis niloticus 81.68 6.00e-137 479.00
IUUC-Oan-072793 Ornithorhynchus anatinus 92.09 2.00e-137 481.00
IUUC-Ocu-074726 Oryctolagus cuniculus 97.44 9.00e-158 548.00
IUUC-Ogl-077661 Oryza glaberrima 50.00 7.00e-03 31.60
IUUC-Ola-086593 Oryzias latipes 81.32 3.00e-135 474.00
IUUC-Oga-089174 Otolemur garnettii 98.90 6.00e-161 559.00
IUUC-Oar-089518 Ovis aries 98.90 7.00e-161 559.00
IUUC-Ptr-090932 Pan troglodytes 99.63 3.00e-162 563.00
IUUC-Pan-091876 Papio anubis 99.63 3.00e-162 563.00
IUUC-Psi-093032 Pelodiscus sinensis 96.34 1.00e-157 548.00
IUUC-Pfo-096274 Poecilia formosa 80.95 2.00e-135 474.00
IUUC-Pab-097701 Pongo abelii 100.00 2.00e-137 481.00
IUUC-Pca-100140 Procavia capensis 96.10 2.00e-133 467.00
IUUC-Pva-102977 Pteropus vampyrus 99.63 3.00e-162 563.00
IUUC-Rno-105030 Rattus norvegicus 98.17 1.00e-159 555.00
IUUC-Sha-107161 Sarcophilus harrisii 93.04 1.00e-149 522.00
IUUC-Tgu-116619 Taeniopygia guttata 94.51 1.00e-152 532.00
IUUC-Tru-118256 Takifugu rubripes 80.95 9.00e-136 476.00
IUUC-Tni-120305 Tetraodon nigroviridis 82.05 6.00e-136 476.00
IUUC-Tbe-127668 Tupaia belangeri 100.00 2.00e-137 481.00
IUUC-Xtr-132803 Xenopus tropicalis 89.74 6.00e-150 523.00
Created Date 25-Jun-2017

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