iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012980

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02046496

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003798.4	ENSBTAT00000004952.4	ENSBTAP00000004952.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.10e-09	36.4	344	382
UBD/Alpha-Helix/CUE	2.60e-11	43.4	459	500

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 344  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 382
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 459  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 500
           5889*********************.***************95 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MPLLFLERFP WPSLRTYTGL LSLLVLLGTG TWNVRSMNQV SAGEGVCKEE VQTRPVEKDP 60
DAGIHNASGL PKANTKHRYL LSHCICVQVL VNTACCILML VAKLIQCIVF GPLRVSERQH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCTGC TCTTTCTCGA GCGCTTCCCC TGGCCCAGCC TCCGCACCTA CACGGGCCTC 60
ANNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	94.79	0.00e+00	1014.00
IUUC-Apl-003404	Anas platyrhynchos	87.99	0.00e+00	927.00
IUUC-Aca-004559	Anolis carolinensis	85.66	0.00e+00	869.00
IUUC-Ame-011640	Astyanax mexicanus	70.36	0.00e+00	800.00
IUUC-Cel-018598	Caenorhabditis elegans	24.54	5.00e-31	129.00
IUUC-Cja-019577	Callithrix jacchus	87.93	0.00e+00	1084.00
IUUC-Cfa-020793	Canis familiaris	95.00	0.00e+00	1037.00
IUUC-Cpo-022387	Cavia porcellus	88.85	0.00e+00	1061.00
IUUC-Csa-023168	Chlorocebus sabaeus	88.70	0.00e+00	1096.00
IUUC-Cho-024433	Choloepus hoffmanni	95.98	0.00e+00	853.00
IUUC-Cin-025215	Ciona intestinalis	45.53	4.00e-148	518.00
IUUC-Csv-026133	Ciona savignyi	47.69	6.00e-135	474.00
IUUC-Dre-027594	Danio rerio	68.91	0.00e+00	742.00
IUUC-Dno-029407	Dasypus novemcinctus	95.89	0.00e+00	1008.00
IUUC-Dor-030961	Dipodomys ordii	95.16	0.00e+00	1025.00
IUUC-Ete-032962	Echinops telfairi	87.46	0.00e+00	857.00
IUUC-Eca-033683	Equus caballus	87.17	0.00e+00	1034.00
IUUC-Eeu-034515	Erinaceus europaeus	99.26	3.00e-79	289.00
IUUC-Fca-035398	Felis catus	96.48	0.00e+00	1004.00
IUUC-Fal-036758	Ficedula albicollis	81.26	0.00e+00	870.00
IUUC-Gmo-039014	Gadus morhua	67.76	0.00e+00	734.00
IUUC-Gga-040575	Gallus gallus	81.27	0.00e+00	995.00
IUUC-Gac-041414	Gasterosteus aculeatus	67.33	0.00e+00	726.00
IUUC-Hsa-046272	Homo sapiens	88.54	0.00e+00	1078.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.02	0.00e+00	1011.00
IUUC-Lch-050491	Latimeria chalumnae	75.04	0.00e+00	857.00
IUUC-Loc-052758	Lepisosteus oculatus	73.49	0.00e+00	807.00
IUUC-Laf-053452	Loxodonta africana	95.89	0.00e+00	1023.00
IUUC-Mcc-055820	Macaca mulatta	95.99	0.00e+00	1023.00
IUUC-Meu-056726	Macropus eugenii	79.48	0.00e+00	801.00
IUUC-Mga-059937	Meleagris gallopavo	87.90	0.00e+00	935.00
IUUC-Mmr-060730	Microcebus murinus	88.08	0.00e+00	1041.00
IUUC-Mdo-062771	Monodelphis domestica	83.86	0.00e+00	1013.00
IUUC-Mmu-064219	Mus musculus	88.02	0.00e+00	1076.00
IUUC-Mpu-066796	Mustela putorius furo	96.53	0.00e+00	1030.00
IUUC-Mlu-068189	Myotis lucifugus	93.15	0.00e+00	991.00
IUUC-Nle-069239	Nomascus leucogenys	88.69	0.00e+00	1059.00
IUUC-Opr-070702	Ochotona princeps	87.68	1.00e-136	479.00
IUUC-Ont-072033	Oreochromis niloticus	69.09	0.00e+00	780.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.30	0.00e+00	862.00
IUUC-Ocu-074145	Oryctolagus cuniculus	86.38	0.00e+00	1061.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	1.00e-11	62.40
IUUC-Ola-087152	Oryzias latipes	67.54	0.00e+00	758.00
IUUC-Oga-088486	Otolemur garnettii	95.53	0.00e+00	1009.00
IUUC-Oar-089310	Ovis aries	98.93	0.00e+00	1074.00
IUUC-Ptr-090649	Pan troglodytes	95.34	0.00e+00	1036.00
IUUC-Pan-091692	Papio anubis	84.52	0.00e+00	1013.00
IUUC-Psi-093064	Pelodiscus sinensis	94.97	0.00e+00	772.00
IUUC-Pma-094763	Petromyzon marinus	77.46	2.00e-96	344.00
IUUC-Ppa-095969	Physcomitrella patens	29.94	5.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	69.19	0.00e+00	771.00
IUUC-Pab-097859	Pongo abelii	95.44	0.00e+00	1020.00
IUUC-Pop-099576	Populus trichocarpa	27.65	1.00e-28	120.00
IUUC-Pca-100344	Procavia capensis	86.75	0.00e+00	1022.00
IUUC-Pva-103114	Pteropus vampyrus	65.90	0.00e+00	694.00
IUUC-Rno-105880	Rattus norvegicus	85.78	0.00e+00	1021.00
IUUC-Sha-107015	Sarcophilus harrisii	92.31	0.00e+00	977.00
IUUC-Sar-113397	Sorex araneus	98.38	0.00e+00	761.00
IUUC-Ssc-115988	Sus scrofa	94.79	8.00e-146	509.00
IUUC-Tgu-116717	Taeniopygia guttata	87.91	0.00e+00	919.00
IUUC-Tru-117805	Takifugu rubripes	66.67	0.00e+00	790.00
IUUC-Tsy-119442	Tarsius syrichta	89.78	0.00e+00	934.00
IUUC-Tni-119777	Tetraodon nigroviridis	72.96	4.00e-171	593.00
IUUC-Tbe-127322	Tupaia belangeri	68.67	1.00e-114	406.00
IUUC-Ttr-128181	Tursiops truncatus	97.67	0.00e+00	1061.00
IUUC-Vpa-130483	Vicugna pacos	85.48	0.00e+00	660.00
IUUC-Xtr-132614	Xenopus tropicalis	73.96	0.00e+00	777.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence