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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108176
UUCD1 version UUC-ScP-00081
Ensembl Protein ID SPAC19G12.01c.1:pep
UniProt Accession O42839; Q9P545; APC4_SCHPO
Genbank Protein ID BAA82675.1; CAB92101.1
Protein Name Anaphase-promoting complex subunit 4; 20S cyclosome/APC complex protein apc4; Cell untimely torn protein 20
Genbank Nucleotide ID AB025243; CU329670
Gene Name cut20; apc4; lid1; SPAC19G12.01c; SPAPJ698.04c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC19G12.01c SPAC19G12.01c.1 SPAC19G12.01c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 22.27 4.00e-04 45.10 IUUC-Hsa-046958
E3 adaptor/Cullin RING/APC_C/APC_C 25.81 2.10e-02 36.20 IUUC-Sce-106193
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
 Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
Protein Sequence
(Fasta)
MVSKSFKYPK KHKFEWINET NRVERVGSGL KRVILCPSME LIAILTCSNH LICCRSNSQR 60
IWDVDFHDLE ATELCWNHDG NLIVVGFKNG ELKIIDSSTG HLVEQRPASR DLAVLMITWA 120
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Protein Fasta Sequence


>IUUC-Spo-108176|E3,APC_C|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
CAACTTCAGT TTTGCAATAT CAGTCTTACT TCCTAATAAA CCATCTATGC TAGCAAATTT 60
AAAAAGGTTG TATGATAATT GTTGAAACTA TCCATTCACT AGATATTTTA TATACCTGAA 120
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Nucleotide Fasta Sequence


>IUUC-Spo-108176|E3,APC_C|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR024789--APC4
IPR024790--APC4_long_dom
IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
Pfam

PF12896--ANAPC4
PF12894--ANAPC4_WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0032153--C:cell division site
GO:0005829--C:cytosol
GO:0044732--C:mitotic spindle pole body
GO:0005634--C:nucleus
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0016567--P:protein ubiquitination
KEGG spo:SPAC19G12.01c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002338 Ailuropoda melanoleuca 23.90 4.00e-07 48.10
IUUC-Atr-003115 Amborella trichopoda 20.70 2.00e-13 68.90
IUUC-Apl-003682 Anas platyrhynchos 23.65 1.00e-06 46.60
IUUC-Aca-005052 Anolis carolinensis 21.18 8.00e-08 50.40
IUUC-Ath-007407 Arabidopsis thaliana 19.50 4.00e-10 58.20
IUUC-Acl-008322 Aspergillus clavatus 24.27 5.00e-27 114.00
IUUC-Afl-008731 Aspergillus flavus 21.01 2.00e-28 119.00
IUUC-Afu-008986 Aspergillus fumigatus 21.09 1.00e-19 89.70
IUUC-Ani-009236 Aspergillus nidulans 21.74 4.00e-22 98.20
IUUC-Ang-009689 Aspergillus niger 18.99 7.00e-17 80.50
IUUC-Ate-010504 Aspergillus terreus 20.66 1.00e-17 83.60
IUUC-Ame-011676 Astyanax mexicanus 20.79 7.00e-11 60.50
IUUC-Bgr-012272 Blumeria graminis 21.26 1.00e-17 82.80
IUUC-Bta-013421 Bos taurus 23.41 1.00e-06 46.60
IUUC-Bdi-014507 Brachypodium distachyon 22.35 1.00e-19 89.40
IUUC-Bol-015675 Brassica oleracea 19.96 9.00e-13 67.00
IUUC-Bra-017735 Brassica rapa 20.61 5.00e-14 71.20
IUUC-Cja-019695 Callithrix jacchus 24.04 2.00e-06 45.80
IUUC-Cfa-020688 Canis familiaris 22.74 4.00e-07 48.10
IUUC-Cpo-022263 Cavia porcellus 23.44 7.00e-06 43.90
IUUC-Csa-023068 Chlorocebus sabaeus 23.41 9.00e-07 47.00
IUUC-Cho-024289 Choloepus hoffmanni 21.54 4.00e-03 35.00
IUUC-Dre-028148 Danio rerio 20.00 4.00e-09 55.10
IUUC-Dse-031568 Dothistroma septosporum 21.20 2.00e-12 65.50
IUUC-Eca-033983 Equus caballus 23.41 1.00e-06 47.00
IUUC-Eeu-035203 Erinaceus europaeus 21.74 1.00e-05 43.10
IUUC-Fca-036269 Felis catus 23.90 4.00e-07 48.50
IUUC-Fal-036650 Ficedula albicollis 21.96 1.00e-06 46.60
IUUC-Fso-038390 Fusarium solani 20.27 5.00e-17 80.90
IUUC-Gmo-039161 Gadus morhua 22.41 9.00e-08 50.40
IUUC-Gac-042424 Gasterosteus aculeatus 21.26 9.00e-06 43.90
IUUC-Gma-043402 Glycine max 19.21 2.00e-11 62.80
IUUC-Ggo-045199 Gorilla gorilla 21.47 6.00e-07 47.80
IUUC-Hsa-046958 Homo sapiens 22.27 3.00e-06 45.40
IUUC-Itr-049044 Ictidomys tridecemlineatus 23.41 1.00e-06 46.60
IUUC-Kpa-049219 Komagataella pastoris 21.68 3.00e-19 88.20
IUUC-Lpe-050838 Leersia perrieri 22.48 7.00e-17 80.50
IUUC-Loc-052502 Lepisosteus oculatus 20.62 3.00e-09 55.10
IUUC-Lma-053262 Leptosphaeria maculans 21.10 5.00e-08 51.60
IUUC-Laf-054361 Loxodonta africana 23.90 5.00e-08 51.20
IUUC-Mcc-054893 Macaca mulatta 23.41 9.00e-07 47.00
IUUC-Mor-056950 Magnaporthe oryzae 18.31 2.00e-14 72.40
IUUC-Mpo-057479 Magnaporthe poae 19.36 3.00e-12 65.10
IUUC-Mtr-058751 Medicago truncatula 20.70 1.00e-12 66.60
IUUC-Mla-059050 Melampsora laricipopulina 25.36 2.00e-04 40.00
IUUC-Mga-059591 Meleagris gallopavo 21.33 5.00e-08 51.20
IUUC-Mvi-060263 Microbotryum violaceum 22.33 3.00e-04 38.90
IUUC-Mmr-060603 Microcebus murinus 23.41 9.00e-07 47.00
IUUC-Mdo-062137 Monodelphis domestica 23.71 8.00e-07 47.40
IUUC-Mmu-064358 Mus musculus 23.08 1.00e-05 43.50
IUUC-Mac-064679 Musa acuminata 24.62 7.00e-04 36.60
IUUC-Mpu-065751 Mustela putorius furo 23.41 2.00e-06 46.20
IUUC-Mlu-067502 Myotis lucifugus 22.74 2.00e-06 46.20
IUUC-Nfi-068257 Neosartorya fischeri 23.47 4.00e-24 104.00
IUUC-Ncr-068721 Neurospora crassa 21.38 1.00e-16 80.10
IUUC-Nle-069134 Nomascus leucogenys 22.71 8.00e-07 47.40
IUUC-Opr-071225 Ochotona princeps 22.44 2.00e-04 38.90
IUUC-Ont-072232 Oreochromis niloticus 19.36 5.00e-06 44.70
IUUC-Oan-073358 Ornithorhynchus anatinus 24.14 4.00e-07 48.10
IUUC-Oba-075232 Oryza barthii 20.67 4.00e-16 78.20
IUUC-Oin-079188 Oryza indica 21.39 6.00e-15 73.90
IUUC-Opu-083725 Oryza punctata 20.97 1.00e-16 80.10
IUUC-Osa-086145 Oryza sativa 28.74 2.00e-08 49.30
IUUC-Ola-086672 Oryzias latipes 20.41 3.00e-09 55.10
IUUC-Oga-088691 Otolemur garnettii 23.41 9.00e-07 47.00
IUUC-Oar-089607 Ovis aries 23.41 1.00e-06 46.60
IUUC-Ptr-090893 Pan troglodytes 22.93 3.00e-06 45.10
IUUC-Pan-092793 Papio anubis 23.08 8.00e-07 47.40
IUUC-Pma-094645 Petromyzon marinus 21.21 2.00e-05 42.00
IUUC-Pno-094772 Phaeosphaeria nodorum 21.49 1.00e-07 50.10
IUUC-Ppa-095509 Physcomitrella patens 21.16 2.00e-09 56.20
IUUC-Pfo-096716 Poecilia formosa 21.50 8.00e-11 60.50
IUUC-Pab-098772 Pongo abelii 22.93 3.00e-06 45.80
IUUC-Pop-099247 Populus trichocarpa 19.37 6.00e-15 73.90
IUUC-Pca-101083 Procavia capensis 23.90 5.00e-08 51.20
IUUC-Ppe-101619 Prunus persica 31.91 2.00e-07 48.90
IUUC-Pva-103168 Pteropus vampyrus 22.38 8.00e-07 47.00
IUUC-Pte-104327 Pyrenophora teres 22.13 5.00e-10 57.80
IUUC-Pyt-104524 Pyrenophora triticirepentis 22.27 9.00e-09 53.50
IUUC-Rno-105693 Rattus norvegicus 22.68 3.00e-06 45.40
IUUC-Sce-106193 Saccharomyces cerevisiae 25.81 1.00e-03 36.20
IUUC-Sha-106567 Sarcophilus harrisii 22.65 3.00e-06 45.40
IUUC-Sja-107773 Schizosaccharomyces japonicus 34.12 3.00e-113 400.00
IUUC-Ssl-108414 Sclerotinia sclerotiorum 18.50 2.00e-19 89.00
IUUC-Smo-108903 Selaginella moellendorffii 31.67 9.00e-06 42.70
IUUC-Sit-110467 Setaria italica 20.58 3.00e-13 68.90
IUUC-Sbi-114693 Sorghum bicolor 21.58 2.00e-17 82.00
IUUC-Ssc-115237 Sus scrofa 22.38 1.00e-06 46.60
IUUC-Tsy-119583 Tarsius syrichta 23.41 1.00e-06 46.20
IUUC-Tni-120268 Tetraodon nigroviridis 23.21 4.00e-07 47.80
IUUC-Tca-121296 Theobroma cacao 19.61 1.00e-13 70.10
IUUC-Tae-123786 Triticum aestivum 22.39 3.00e-18 85.10
IUUC-Tbe-127711 Tupaia belangeri 22.38 1.00e-06 46.60
IUUC-Ttr-128537 Tursiops truncatus 23.44 1.00e-05 43.50
IUUC-Uma-129395 Ustilago maydis 25.41 4.80e-02 31.60
IUUC-Vda-130028 Verticillium dahliae 21.74 1.00e-11 63.20
IUUC-Vvi-131490 Vitis vinifera 21.05 2.00e-14 72.40
IUUC-Xtr-132380 Xenopus tropicalis 19.90 8.00e-07 47.00
IUUC-Xma-133597 Xiphophorus maculatus 21.50 3.00e-10 58.90
IUUC-Yli-134609 Yarrowia lipolytica 23.19 7.00e-22 97.10
Created Date 25-Jun-2017

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