iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021635

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAKN02000610

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000014407.3	ENSCPOT00000014552.2	ENSCPOP00000012976.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.10e-130	432.9	588	923

Active Site

Position(s)	Description	Evidence
892	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 588  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 675
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 676  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 761
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           +r+ +g++ q++af +Gfnev+pl++l++F+e+elel +c + e  d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqF
   Q: 762  WRFSRGVQDQTKAFLDGFNEVVPLQWLQYFDEKELELRCCLQrEIKDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQF 849
           ******************************************55569**********99.***************************** PP
   S: 268  vTgssrlPlgGfaelk......prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTg++rlPlgGfael+      p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 850  VTGTCRLPLGGFAELMglgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 923
           ************************************************************************96 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MATASPRSDA SNNHCGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI KKTAKSSSSS 60
NPKWDEQLTV SVTPQTILEF RVWSHHTLKA DALLGRATID LKQALLMHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CCTCACCAAG GTCTGATGCT AGTAATAACC ACTGTGGAAG GTTACAGTTA 60
CAGGTAACTG GTAAGTGATT TTCACAATGC AGTATGTTAA TTCTTTTGGA AGCCTGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	88.98	0.00e+00	1691.00
IUUC-Apl-003310	Anas platyrhynchos	80.15	0.00e+00	1502.00
IUUC-Aca-005388	Anolis carolinensis	77.38	0.00e+00	1424.00
IUUC-Bta-012857	Bos taurus	88.01	0.00e+00	1643.00
IUUC-Cja-019448	Callithrix jacchus	90.17	0.00e+00	1720.00
IUUC-Cfa-020728	Canis familiaris	89.85	0.00e+00	1692.00
IUUC-Csa-023805	Chlorocebus sabaeus	90.38	0.00e+00	1293.00
IUUC-Cho-024943	Choloepus hoffmanni	79.22	0.00e+00	1157.00
IUUC-Csv-026256	Ciona savignyi	71.08	0.00e+00	870.00
IUUC-Dre-028245	Danio rerio	71.11	0.00e+00	1190.00
IUUC-Dno-029618	Dasypus novemcinctus	89.74	0.00e+00	1692.00
IUUC-Dor-030665	Dipodomys ordii	76.41	0.00e+00	1158.00
IUUC-Ete-032779	Echinops telfairi	91.59	0.00e+00	1095.00
IUUC-Eca-033313	Equus caballus	88.23	0.00e+00	1628.00
IUUC-Eeu-035259	Erinaceus europaeus	81.21	0.00e+00	1501.00
IUUC-Fca-035420	Felis catus	88.23	0.00e+00	1679.00
IUUC-Fal-037335	Ficedula albicollis	80.00	0.00e+00	1499.00
IUUC-Gmo-039172	Gadus morhua	83.89	0.00e+00	1013.00
IUUC-Gga-040246	Gallus gallus	80.30	0.00e+00	1499.00
IUUC-Gac-042211	Gasterosteus aculeatus	89.25	0.00e+00	1121.00
IUUC-Ggo-045001	Gorilla gorilla	87.70	0.00e+00	1506.00
IUUC-Hsa-046544	Homo sapiens	89.42	0.00e+00	1710.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	90.81	0.00e+00	1690.00
IUUC-Lch-050398	Latimeria chalumnae	75.16	0.00e+00	1365.00
IUUC-Loc-052116	Lepisosteus oculatus	69.33	0.00e+00	1254.00
IUUC-Laf-053551	Loxodonta africana	87.49	0.00e+00	1632.00
IUUC-Mga-059986	Meleagris gallopavo	79.68	0.00e+00	1504.00
IUUC-Mmr-060945	Microcebus murinus	86.84	0.00e+00	1638.00
IUUC-Mdo-063024	Monodelphis domestica	79.63	0.00e+00	1438.00
IUUC-Mmu-063202	Mus musculus	86.90	0.00e+00	1599.00
IUUC-Mpu-065773	Mustela putorius furo	89.09	0.00e+00	1680.00
IUUC-Mlu-067373	Myotis lucifugus	93.63	0.00e+00	627.00
IUUC-Nle-069188	Nomascus leucogenys	89.52	0.00e+00	1711.00
IUUC-Opr-070965	Ochotona princeps	85.82	0.00e+00	1598.00
IUUC-Ont-072226	Oreochromis niloticus	89.95	0.00e+00	1130.00
IUUC-Oan-073497	Ornithorhynchus anatinus	82.31	0.00e+00	1503.00
IUUC-Ocu-073891	Oryctolagus cuniculus	85.84	0.00e+00	1575.00
IUUC-Ola-087438	Oryzias latipes	87.03	0.00e+00	1124.00
IUUC-Oga-087922	Otolemur garnettii	89.20	0.00e+00	1684.00
IUUC-Oar-089317	Ovis aries	86.95	0.00e+00	1611.00
IUUC-Ptr-090484	Pan troglodytes	89.31	0.00e+00	1709.00
IUUC-Pan-092117	Papio anubis	89.20	0.00e+00	1704.00
IUUC-Psi-093338	Pelodiscus sinensis	80.71	0.00e+00	1514.00
IUUC-Pma-094279	Petromyzon marinus	72.08	0.00e+00	825.00
IUUC-Pfo-096171	Poecilia formosa	89.78	0.00e+00	1129.00
IUUC-Pab-098654	Pongo abelii	87.72	0.00e+00	1236.00
IUUC-Pca-100501	Procavia capensis	69.27	0.00e+00	889.00
IUUC-Pva-102811	Pteropus vampyrus	77.54	0.00e+00	1394.00
IUUC-Rno-106125	Rattus norvegicus	87.12	0.00e+00	1617.00
IUUC-Sha-107243	Sarcophilus harrisii	82.06	0.00e+00	1512.00
IUUC-Ssc-115368	Sus scrofa	89.32	0.00e+00	1664.00
IUUC-Tgu-117079	Taeniopygia guttata	79.47	0.00e+00	1476.00
IUUC-Tru-118062	Takifugu rubripes	70.11	0.00e+00	1305.00
IUUC-Tsy-119507	Tarsius syrichta	84.45	0.00e+00	1574.00
IUUC-Tni-120151	Tetraodon nigroviridis	89.27	0.00e+00	1119.00
IUUC-Vpa-130390	Vicugna pacos	77.20	0.00e+00	897.00
IUUC-Xtr-132877	Xenopus tropicalis	66.95	0.00e+00	1185.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence