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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063202
UUCD1 version UUC-MuM-00039
Ensembl Protein ID ENSMUSP00000103881.2
UniProt Accession Q8BZZ3; Q8BIV9; Q8VDP8; WWP1_MOUSE
Genbank Protein ID BAC28168.1; BAC38473.1; AAH21470.1; AAH51405.1
Protein Name NEDD4-like E3 ubiquitin-protein ligase WWP1; HECT-type E3 ubiquitin transferase WWP1; WW domain-containing protein 1
Genbank Nucleotide ID AK033138; AK082346; BC021470; BC051405
Gene Name Wwp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041058.15 ENSMUST00000108246.8 ENSMUSP00000103881.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 18083927; 17934096
Classification
Family E-value Score Start End
E3 activity/HECT 1.40e-134 449.9 585 917
Active Site
Position(s) Description Evidence
886 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 585  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 672
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 673  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 758
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 759  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 846
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 847  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 917
           *********************************************************************96 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
Protein Sequence
(Fasta)
MATASPRSDT SDIHSGRLQL KVTVSSAKLK RKKNWFGTAI YTEVIVDGEV KKTAKSSSSS 60
NPKWDEQLIV NVTPQTTLEF RVWSHHTLKA DALLGKATVD LKQVLLTHNR KLEKVKEQLK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063202|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGTGTCGGC GCGCTTGGCG TGCGGGATCC GAGTGGCTGC GGGCGGCCTG AGCTGCCCGG 60
CCGACGCCTG CTGCGAGATG GCGATCTTGG GCGCGGAGGG CTGAGGAGGC GCCGCCGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063202|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030324--P:lung development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0030217--P:T cell differentiation
KEGG mmu:107568
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001213 Ailuropoda melanoleuca 90.67 0.00e+00 1676.00
IUUC-Apl-003310 Anas platyrhynchos 81.23 0.00e+00 1498.00
IUUC-Aca-005388 Anolis carolinensis 79.14 0.00e+00 1428.00
IUUC-Bta-012857 Bos taurus 89.48 0.00e+00 1636.00
IUUC-Cel-018299 Caenorhabditis elegans 67.36 0.00e+00 840.00
IUUC-Cja-019448 Callithrix jacchus 91.00 0.00e+00 1696.00
IUUC-Cfa-020728 Canis familiaris 91.32 0.00e+00 1669.00
IUUC-Cpo-021635 Cavia porcellus 87.23 0.00e+00 1642.00
IUUC-Csa-023805 Chlorocebus sabaeus 92.69 0.00e+00 1280.00
IUUC-Cho-024943 Choloepus hoffmanni 80.32 0.00e+00 1120.00
IUUC-Cin-025212 Ciona intestinalis 55.52 0.00e+00 956.00
IUUC-Csv-026256 Ciona savignyi 72.84 0.00e+00 902.00
IUUC-Dre-028245 Danio rerio 90.05 0.00e+00 1144.00
IUUC-Dno-029618 Dasypus novemcinctus 90.67 0.00e+00 1675.00
IUUC-Dor-030665 Dipodomys ordii 77.14 0.00e+00 1130.00
IUUC-Dme-032041 Drosophila melanogaster 71.19 0.00e+00 897.00
IUUC-Ete-032779 Echinops telfairi 95.07 0.00e+00 1115.00
IUUC-Eca-033313 Equus caballus 87.85 0.00e+00 1614.00
IUUC-Eeu-035259 Erinaceus europaeus 82.97 0.00e+00 1492.00
IUUC-Fca-035420 Felis catus 89.80 0.00e+00 1662.00
IUUC-Fal-037335 Ficedula albicollis 81.36 0.00e+00 1491.00
IUUC-Gmo-039172 Gadus morhua 86.62 0.00e+00 1050.00
IUUC-Gga-040246 Gallus gallus 81.21 0.00e+00 1488.00
IUUC-Gac-042211 Gasterosteus aculeatus 92.52 0.00e+00 1152.00
IUUC-Ggo-045001 Gorilla gorilla 90.51 0.00e+00 1492.00
IUUC-Hsa-046544 Homo sapiens 90.56 0.00e+00 1689.00
IUUC-Itr-048860 Ictidomys tridecemlineatus 91.11 0.00e+00 1662.00
IUUC-Lch-050398 Latimeria chalumnae 93.39 0.00e+00 1153.00
IUUC-Loc-052116 Lepisosteus oculatus 93.34 0.00e+00 1171.00
IUUC-Laf-053551 Loxodonta africana 88.41 0.00e+00 1625.00
IUUC-Mla-058996 Melampsora laricipopulina 45.32 3.00e-150 525.00
IUUC-Mga-059986 Meleagris gallopavo 81.12 0.00e+00 1496.00
IUUC-Mmr-060945 Microcebus murinus 87.54 0.00e+00 1618.00
IUUC-Mdo-063024 Monodelphis domestica 81.19 0.00e+00 1446.00
IUUC-Mpu-065773 Mustela putorius furo 90.37 0.00e+00 1652.00
IUUC-Mlu-067373 Myotis lucifugus 97.11 0.00e+00 649.00
IUUC-Nle-069188 Nomascus leucogenys 91.21 0.00e+00 1700.00
IUUC-Opr-070965 Ochotona princeps 86.52 0.00e+00 1591.00
IUUC-Ont-072226 Oreochromis niloticus 92.29 0.00e+00 1160.00
IUUC-Oan-073497 Ornithorhynchus anatinus 85.05 0.00e+00 1525.00
IUUC-Ocu-073891 Oryctolagus cuniculus 86.86 0.00e+00 1566.00
IUUC-Ola-087438 Oryzias latipes 91.65 0.00e+00 1162.00
IUUC-Oga-087922 Otolemur garnettii 89.94 0.00e+00 1644.00
IUUC-Oar-089317 Ovis aries 88.31 0.00e+00 1605.00
IUUC-Ptr-090484 Pan troglodytes 90.46 0.00e+00 1689.00
IUUC-Pan-092117 Papio anubis 90.89 0.00e+00 1694.00
IUUC-Psi-093338 Pelodiscus sinensis 81.49 0.00e+00 1506.00
IUUC-Pma-094279 Petromyzon marinus 75.09 0.00e+00 844.00
IUUC-Pfo-096171 Poecilia formosa 91.82 0.00e+00 1162.00
IUUC-Pab-098654 Pongo abelii 90.29 0.00e+00 1236.00
IUUC-Pva-102811 Pteropus vampyrus 78.63 0.00e+00 1387.00
IUUC-Rno-106125 Rattus norvegicus 97.39 0.00e+00 1768.00
IUUC-Sha-107243 Sarcophilus harrisii 83.93 0.00e+00 1524.00
IUUC-Sre-114929 Sporisorium reilianum 46.19 2.00e-151 530.00
IUUC-Ssc-115368 Sus scrofa 89.41 0.00e+00 1642.00
IUUC-Tgu-117079 Taeniopygia guttata 80.58 0.00e+00 1474.00
IUUC-Tru-118062 Takifugu rubripes 71.72 0.00e+00 1340.00
IUUC-Tsy-119507 Tarsius syrichta 85.47 0.00e+00 1556.00
IUUC-Tni-120151 Tetraodon nigroviridis 92.11 0.00e+00 1149.00
IUUC-Ttr-129260 Tursiops truncatus 80.15 0.00e+00 1411.00
IUUC-Uma-129332 Ustilago maydis 46.53 1.00e-145 510.00
IUUC-Vpa-130390 Vicugna pacos 78.63 0.00e+00 870.00
IUUC-Xtr-132877 Xenopus tropicalis 69.28 0.00e+00 1194.00
Created Date 25-Jun-2017

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