iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.30e-10	40.9	758	810

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPenF 58
           +v +l+dy+a+  deL++++G+ v+v+  +  ++ +W+ +   l+g++G +P n+
   Q: 758  VVYALWDYSAEFGDELSFREGESVTVLrRDGPEETDWWWA--SLHGQEGYVPRNY 810
           6889***********************877788999**99..9***********9 PP

Organism

Mus musculus

Functional Description
(View)

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity).

Protein Sequence
(Fasta)

MDSEAFQHAR DLLDLNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGAQ 60
AGVPSRMARY STSPVPEHFG SRGSPQKIAT DGIEARFGRS ESAPSLHPYS PLSPKGRPSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTTTAAA GAGACAGAAG ATCTATTTGC AGCATTCTTG CAAAAGCTAG GTAAGAATTC 60
TGGTTGTCAC GATTGTACTT TTAAAGCTAG AGTGTATCTT CGGAAGTCCC TGGTGCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0728--SH3 domain
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR028320--iASPP
IPR001452--SH3_domain

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3

Pfam

PF12796--Ank_2
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00248--ANK
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0005913--C:cell-cell adherens junction
GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005634--C:nucleus
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0042802--F:identical protein binding
GO:0006915--P:apoptotic process
GO:0060048--P:cardiac muscle contraction
GO:0003215--P:cardiac right ventricle morphogenesis
GO:0031076--P:embryonic camera-type eye development
GO:0042633--P:hair cycle
GO:0035264--P:multicellular organism growth
GO:0048871--P:multicellular organismal homeostasis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045597--P:positive regulation of cell differentiation
GO:0009791--P:post-embryonic development
GO:0006351--P:transcription, DNA-templated
GO:0003229--P:ventricular cardiac muscle tissue development

KEGG

mmu:333654

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001236	Ailuropoda melanoleuca	86.88	0.00e+00	654.00
IUUC-Aca-004907	Anolis carolinensis	80.20	2.00e-98	353.00
IUUC-Bta-012555	Bos taurus	83.09	0.00e+00	1083.00
IUUC-Cfa-020223	Canis familiaris	86.22	0.00e+00	641.00
IUUC-Cpo-022180	Cavia porcellus	78.57	0.00e+00	1113.00
IUUC-Csa-023984	Chlorocebus sabaeus	93.66	3.00e-159	555.00
IUUC-Dre-027600	Danio rerio	48.59	2.00e-91	330.00
IUUC-Dno-029486	Dasypus novemcinctus	88.29	0.00e+00	729.00
IUUC-Dor-030334	Dipodomys ordii	87.75	2.00e-163	570.00
IUUC-Eca-033590	Equus caballus	84.93	0.00e+00	677.00
IUUC-Gac-041648	Gasterosteus aculeatus	52.06	2.00e-94	340.00
IUUC-Hsa-046974	Homo sapiens	84.54	2.00e-166	579.00
IUUC-Itr-048093	Ictidomys tridecemlineatus	84.22	0.00e+00	1031.00
IUUC-Lch-049426	Latimeria chalumnae	68.28	1.00e-77	284.00
IUUC-Laf-054593	Loxodonta africana	84.32	0.00e+00	1117.00
IUUC-Mcc-055896	Macaca mulatta	84.29	2.00e-166	579.00
IUUC-Mmr-061007	Microcebus murinus	80.86	0.00e+00	1012.00
IUUC-Mac-065548	Musa acuminata	34.52	8.00e-06	45.40
IUUC-Mpu-066381	Mustela putorius furo	86.97	2.00e-180	625.00
IUUC-Nle-069627	Nomascus leucogenys	94.10	1.00e-164	573.00
IUUC-Ont-071459	Oreochromis niloticus	50.58	4.00e-91	329.00
IUUC-Ocu-074924	Oryctolagus cuniculus	74.86	5.00e-119	421.00
IUUC-Obr-076350	Oryza brachyantha	34.07	7.00e-03	35.40
IUUC-Olo-080981	Oryza longistaminata	34.07	9.00e-03	35.00
IUUC-Ola-087294	Oryzias latipes	50.75	1.00e-93	338.00
IUUC-Oga-088356	Otolemur garnettii	85.58	0.00e+00	1144.00
IUUC-Oar-089777	Ovis aries	93.43	7.00e-159	554.00
IUUC-Ptr-090843	Pan troglodytes	84.29	9.00e-166	577.00
IUUC-Pfo-096934	Poecilia formosa	51.81	4.00e-96	345.00
IUUC-Pab-098564	Pongo abelii	94.10	5.00e-165	573.00
IUUC-Pca-100382	Procavia capensis	76.99	0.00e+00	886.00
IUUC-Pva-102159	Pteropus vampyrus	94.32	2.00e-167	583.00
IUUC-Rno-106055	Rattus norvegicus	94.80	0.00e+00	1283.00
IUUC-Tru-117623	Takifugu rubripes	52.05	4.00e-93	336.00
IUUC-Tni-120255	Tetraodon nigroviridis	50.57	2.00e-91	330.00
IUUC-Xtr-132435	Xenopus tropicalis	71.43	2.00e-89	323.00
IUUC-Xma-133548	Xiphophorus maculatus	50.98	1.00e-93	337.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence