iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089272

Ensembl Protein ID

ENSOARP00000020211.1

UniProt Accession

W5QBW4; W5QBW4_SHEEP

Genbank Protein ID

ENSOARP00000020211

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01003966

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000018811.1	ENSOART00000020491.1	ENSOARP00000020211.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.70e-15	55.0	794	845

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 794  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 845
           688*********************9.999999*****..9*************86 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MEPWKQCAQW LIHCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI 60
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGCGGCGG CGTAGCCGCC GCCGCATCTC CGCTGCCTGC CCGGGCCGGG CAGCGTTCAG 60
GCGCCGTCGG GCATGGAGCC GTGGAAGCAA TGCGCGCAGT GGCTCATCCA CTGCAAGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

KEGG

oas:101120709

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	95.99	0.00e+00	1604.00
IUUC-Apl-003734	Anas platyrhynchos	86.26	0.00e+00	1349.00
IUUC-Aca-004477	Anolis carolinensis	81.37	0.00e+00	1383.00
IUUC-Ame-011279	Astyanax mexicanus	66.20	0.00e+00	1110.00
IUUC-Bta-012722	Bos taurus	98.58	0.00e+00	1648.00
IUUC-Cel-018578	Caenorhabditis elegans	28.81	3.00e-70	260.00
IUUC-Cja-018941	Callithrix jacchus	96.07	0.00e+00	1581.00
IUUC-Cfa-020266	Canis familiaris	95.92	0.00e+00	1425.00
IUUC-Cpo-021966	Cavia porcellus	93.46	0.00e+00	1360.00
IUUC-Csa-023892	Chlorocebus sabaeus	95.78	0.00e+00	1462.00
IUUC-Cin-025115	Ciona intestinalis	36.47	3.00e-136	479.00
IUUC-Csv-025995	Ciona savignyi	35.27	1.00e-144	506.00
IUUC-Dre-028199	Danio rerio	66.51	0.00e+00	1115.00
IUUC-Dno-029474	Dasypus novemcinctus	94.92	0.00e+00	1584.00
IUUC-Eca-033961	Equus caballus	95.92	0.00e+00	1457.00
IUUC-Eeu-034719	Erinaceus europaeus	74.44	0.00e+00	776.00
IUUC-Fca-036572	Felis catus	95.81	0.00e+00	1570.00
IUUC-Fal-036802	Ficedula albicollis	84.69	0.00e+00	1481.00
IUUC-Gmo-039409	Gadus morhua	69.57	0.00e+00	1159.00
IUUC-Gga-040884	Gallus gallus	85.60	0.00e+00	1466.00
IUUC-Gac-041395	Gasterosteus aculeatus	71.33	0.00e+00	1235.00
IUUC-Ggo-044460	Gorilla gorilla	93.31	0.00e+00	1377.00
IUUC-Hsa-046099	Homo sapiens	92.91	0.00e+00	1584.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	91.05	0.00e+00	1381.00
IUUC-Lch-049650	Latimeria chalumnae	82.63	1.00e-110	392.00
IUUC-Loc-052487	Lepisosteus oculatus	73.10	0.00e+00	1234.00
IUUC-Laf-054564	Loxodonta africana	94.45	0.00e+00	1582.00
IUUC-Mcc-054622	Macaca mulatta	92.91	0.00e+00	1582.00
IUUC-Meu-056680	Macropus eugenii	84.53	0.00e+00	1412.00
IUUC-Mga-060013	Meleagris gallopavo	81.98	0.00e+00	1390.00
IUUC-Mmr-061251	Microcebus murinus	90.94	0.00e+00	1597.00
IUUC-Mdo-061875	Monodelphis domestica	91.85	0.00e+00	1552.00
IUUC-Mmu-063735	Mus musculus	93.86	0.00e+00	1593.00
IUUC-Mpu-065856	Mustela putorius furo	96.10	0.00e+00	1602.00
IUUC-Mlu-068108	Myotis lucifugus	90.06	0.00e+00	1509.00
IUUC-Nle-069863	Nomascus leucogenys	91.60	0.00e+00	1545.00
IUUC-Opr-070372	Ochotona princeps	82.92	0.00e+00	1031.00
IUUC-Ont-072286	Oreochromis niloticus	71.51	0.00e+00	1222.00
IUUC-Ocu-074194	Oryctolagus cuniculus	95.51	0.00e+00	1589.00
IUUC-Ola-086336	Oryzias latipes	70.20	0.00e+00	1212.00
IUUC-Ptr-090652	Pan troglodytes	93.76	0.00e+00	1582.00
IUUC-Pan-092550	Papio anubis	92.13	0.00e+00	1395.00
IUUC-Psi-093784	Pelodiscus sinensis	80.57	0.00e+00	1258.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	68.64	0.00e+00	1206.00
IUUC-Pab-098698	Pongo abelii	93.74	0.00e+00	1583.00
IUUC-Pva-102262	Pteropus vampyrus	95.44	0.00e+00	1533.00
IUUC-Rno-105421	Rattus norvegicus	93.51	0.00e+00	1601.00
IUUC-Sha-107325	Sarcophilus harrisii	91.85	0.00e+00	1568.00
IUUC-Sar-113456	Sorex araneus	90.08	0.00e+00	1520.00
IUUC-Tgu-116595	Taeniopygia guttata	83.18	0.00e+00	1390.00
IUUC-Tru-117884	Takifugu rubripes	66.04	0.00e+00	1190.00
IUUC-Tsy-119429	Tarsius syrichta	87.68	0.00e+00	1319.00
IUUC-Tni-119951	Tetraodon nigroviridis	68.89	0.00e+00	1136.00
IUUC-Tbe-127995	Tupaia belangeri	84.00	1.00e-176	613.00
IUUC-Ttr-128281	Tursiops truncatus	96.81	0.00e+00	1613.00
IUUC-Xtr-132427	Xenopus tropicalis	72.74	0.00e+00	1292.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence