iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRTarBase	microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17392428
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17392428; 15820693

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-57	189.5	260	297
UBD/Beta-Prp	1.70e-67	228.0	339	501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvllks 38
           gHt+sv cl++ d + ++sGs D t++vWD+ tg ++k+
   Q: 260  GHTGSVLCLQY-DnRVIISGSSDATVRVWDVETGECIKT 297
           8**********.4499********************985 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvh 146
           r l gh a+v+ v+f+++  ++v++s Drtikvw+++t + v+tl gh + + +l++      +vsGs+d+tir+wd+++g cl+ +l+gh+++v+c++++
   Q: 339  RVLVGHRAAVNVVDFDDR--YIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYRG--RLVVSGSSDNTIRLWDIHSGVCLR-VLEGHEELVRCIRFD 434
           3469**************..8***********************************998..************************.*************** PP
   S: 147  pdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +  + +vsG++D+++++Wdl         +++ +l  l + ht++v  l+fd+  +++vs s+d t+ +wd+
   Q: 435  E--KRIVSGAYDGKIKVWDLqaaldpralSSEICLCSLVQ-HTGRVFRLQFDD--FQIVSSSHDDTILIWDF 501
           *..*****************99999999999999999988.************..99*************97 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).

Protein Sequence
(Fasta)

MSSPHRASTT QQLADLSLTE GEHDEGKPLS IDYLQGHEGL IEEVLKWSEH EQLDFMDKIV 60
HRLSHYQLGK VDNFIRPMLQ RDFISNLPAH LVELILFNVN SDSLKSCEEV STSWRCALAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATTAAAT GTCTTCACCG CACCGAGCTT CAACAACTCA GCAGCTGGCG GACTTATCGT 60
TGACGGAAGG TGAACACGAT GAGGGCAAAC CGCTTTCTAT TGACTACCTT CAAGGGCACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008013--F:beta-catenin binding
GO:0019902--F:phosphatase binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0008285--P:negative regulation of cell proliferation
GO:0010826--P:negative regulation of centrosome duplication
GO:0048812--P:neuron projection morphogenesis
GO:0031647--P:regulation of protein stability
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	63.71	0.00e+00	635.00
IUUC-Apl-003449	Anas platyrhynchos	63.23	0.00e+00	635.00
IUUC-Aca-004410	Anolis carolinensis	65.07	0.00e+00	637.00
IUUC-Ago-007794	Ashbya gossypii	26.30	6.00e-35	140.00
IUUC-Acl-008160	Aspergillus clavatus	31.99	3.00e-44	172.00
IUUC-Afu-008790	Aspergillus fumigatus	29.91	8.00e-39	154.00
IUUC-Ani-009324	Aspergillus nidulans	30.43	7.00e-44	170.00
IUUC-Ang-009731	Aspergillus niger	37.46	1.00e-46	180.00
IUUC-Aor-010185	Aspergillus oryzae	27.26	4.00e-43	168.00
IUUC-Ate-010492	Aspergillus terreus	26.62	2.00e-43	169.00
IUUC-Ame-011393	Astyanax mexicanus	63.99	0.00e+00	636.00
IUUC-Bgr-012194	Blumeria graminis	29.67	1.00e-47	183.00
IUUC-Bta-012920	Bos taurus	63.16	0.00e+00	635.00
IUUC-Bci-013685	Botrytis cinerea	29.66	7.00e-51	194.00
IUUC-Cja-019121	Callithrix jacchus	64.33	0.00e+00	635.00
IUUC-Cfa-020553	Canis familiaris	63.71	0.00e+00	636.00
IUUC-Cpo-022151	Cavia porcellus	62.75	0.00e+00	627.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.08	1.00e-36	146.00
IUUC-Csa-023688	Chlorocebus sabaeus	63.71	0.00e+00	636.00
IUUC-Cho-024658	Choloepus hoffmanni	42.42	2.00e-48	185.00
IUUC-Cin-025188	Ciona intestinalis	64.29	5.00e-178	616.00
IUUC-Csv-026020	Ciona savignyi	63.83	4.00e-173	600.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	30.49	2.00e-55	209.00
IUUC-Cme-027168	Cyanidioschyzon merolae	28.39	4.00e-29	122.00
IUUC-Dre-028160	Danio rerio	63.58	0.00e+00	634.00
IUUC-Dno-029484	Dasypus novemcinctus	60.42	3.00e-179	620.00
IUUC-Dor-030498	Dipodomys ordii	62.75	0.00e+00	629.00
IUUC-Dse-031196	Dothistroma septosporum	38.49	4.00e-50	192.00
IUUC-Dme-031885	Drosophila melanogaster	62.75	0.00e+00	641.00
IUUC-Ete-032978	Echinops telfairi	51.10	7.00e-131	459.00
IUUC-Eca-033804	Equus caballus	63.16	0.00e+00	634.00
IUUC-Eeu-034760	Erinaceus europaeus	63.96	9.00e-120	422.00
IUUC-Fca-035887	Felis catus	63.16	0.00e+00	635.00
IUUC-Fal-036783	Ficedula albicollis	63.36	0.00e+00	639.00
IUUC-Fox-037978	Fusarium oxysporum	30.56	4.00e-55	208.00
IUUC-Fso-038077	Fusarium solani	29.55	4.00e-50	191.00
IUUC-Gmo-038590	Gadus morhua	63.99	0.00e+00	633.00
IUUC-Ggr-039974	Gaeumannomyces graminis	30.98	1.00e-52	200.00
IUUC-Gga-040628	Gallus gallus	63.13	0.00e+00	640.00
IUUC-Gac-041305	Gasterosteus aculeatus	64.20	0.00e+00	637.00
IUUC-Ggo-045369	Gorilla gorilla	63.71	0.00e+00	635.00
IUUC-Hsa-045962	Homo sapiens	63.71	0.00e+00	636.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	63.03	2.00e-164	570.00
IUUC-Lch-050460	Latimeria chalumnae	62.96	0.00e+00	631.00
IUUC-Loc-052686	Lepisosteus oculatus	64.29	0.00e+00	639.00
IUUC-Lma-053289	Leptosphaeria maculans	32.35	2.00e-45	176.00
IUUC-Laf-054022	Loxodonta africana	63.71	0.00e+00	637.00
IUUC-Mcc-055822	Macaca mulatta	63.16	0.00e+00	636.00
IUUC-Meu-056078	Macropus eugenii	55.37	4.00e-147	513.00
IUUC-Mor-057283	Magnaporthe oryzae	31.14	6.00e-54	204.00
IUUC-Mpo-057540	Magnaporthe poae	30.77	3.00e-53	202.00
IUUC-Mla-058989	Melampsora laricipopulina	40.57	4.00e-60	223.00
IUUC-Mga-059388	Meleagris gallopavo	63.88	0.00e+00	635.00
IUUC-Mvi-060284	Microbotryum violaceum	43.96	2.00e-70	259.00
IUUC-Mmr-060969	Microcebus murinus	63.71	0.00e+00	636.00
IUUC-Mdo-063041	Monodelphis domestica	64.66	0.00e+00	634.00
IUUC-Mmu-063851	Mus musculus	63.36	0.00e+00	638.00
IUUC-Mpu-065716	Mustela putorius furo	63.16	0.00e+00	635.00
IUUC-Mlu-067001	Myotis lucifugus	63.16	0.00e+00	634.00
IUUC-Ncr-068639	Neurospora crassa	35.78	4.00e-38	152.00
IUUC-Nle-069548	Nomascus leucogenys	61.83	0.00e+00	636.00
IUUC-Opr-071229	Ochotona princeps	62.96	0.00e+00	633.00
IUUC-Ont-071792	Oreochromis niloticus	64.20	0.00e+00	638.00
IUUC-Oan-072782	Ornithorhynchus anatinus	63.36	0.00e+00	639.00
IUUC-Ocu-074246	Oryctolagus cuniculus	63.71	0.00e+00	636.00
IUUC-Ola-086985	Oryzias latipes	63.79	0.00e+00	637.00
IUUC-Oga-088244	Otolemur garnettii	63.71	0.00e+00	634.00
IUUC-Oar-090412	Ovis aries	63.16	0.00e+00	636.00
IUUC-Ptr-091039	Pan troglodytes	63.16	0.00e+00	635.00
IUUC-Pan-092826	Papio anubis	63.71	0.00e+00	636.00
IUUC-Psi-093887	Pelodiscus sinensis	63.16	0.00e+00	634.00
IUUC-Pma-094315	Petromyzon marinus	60.58	6.00e-163	566.00
IUUC-Pfo-096783	Poecilia formosa	63.79	0.00e+00	639.00
IUUC-Pab-097680	Pongo abelii	63.51	0.00e+00	635.00
IUUC-Pca-100843	Procavia capensis	59.68	2.00e-161	560.00
IUUC-Pva-102547	Pteropus vampyrus	62.96	0.00e+00	628.00
IUUC-Pgr-103331	Puccinia graminis	31.60	5.00e-51	194.00
IUUC-Ptt-103853	Puccinia triticina	35.10	4.00e-55	207.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	32.80	2.00e-44	173.00
IUUC-Rno-105246	Rattus norvegicus	63.36	0.00e+00	637.00
IUUC-Sha-107454	Sarcophilus harrisii	64.66	0.00e+00	635.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	34.24	7.00e-71	259.00
IUUC-Spo-108200	Schizosaccharomyces pombe	31.55	8.00e-65	239.00
IUUC-Sar-113471	Sorex araneus	50.00	2.00e-124	438.00
IUUC-Sre-114916	Sporisorium reilianum	32.29	2.00e-43	169.00
IUUC-Ssc-115490	Sus scrofa	63.71	0.00e+00	632.00
IUUC-Tgu-117445	Taeniopygia guttata	63.67	0.00e+00	635.00
IUUC-Tru-117671	Takifugu rubripes	64.14	0.00e+00	640.00
IUUC-Tsy-118983	Tarsius syrichta	62.30	6.00e-179	619.00
IUUC-Tni-120359	Tetraodon nigroviridis	64.34	0.00e+00	640.00
IUUC-Tre-122207	Trichoderma reesei	35.36	2.00e-53	202.00
IUUC-Tvi-122344	Trichoderma virens	33.09	2.00e-53	202.00
IUUC-Tme-127141	Tuber melanosporum	32.08	2.00e-58	218.00
IUUC-Tbe-127418	Tupaia belangeri	61.54	1.00e-175	608.00
IUUC-Ttr-128946	Tursiops truncatus	63.51	0.00e+00	635.00
IUUC-Uma-129491	Ustilago maydis	33.88	4.00e-45	175.00
IUUC-Vda-129941	Verticillium dahliae	30.49	1.00e-52	199.00
IUUC-Vpa-130668	Vicugna pacos	63.16	0.00e+00	635.00
IUUC-Xtr-132861	Xenopus tropicalis	63.88	0.00e+00	632.00
IUUC-Xma-133187	Xiphophorus maculatus	81.06	4.00e-129	452.00
IUUC-Yli-134582	Yarrowia lipolytica	32.25	6.00e-52	197.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence