iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17953484

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0062	16.6	1062	1105

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
              l+  +l  i+++l++++l+++ +vc+ w+++a ++ lwk++
   Q: 1062 NLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKM 1105
           56788999************************99999****987 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.

Protein Sequence
(Fasta)

MSTAVETGSS PAKSNSNNSS SGGNNNNGNG NLSPNAKGVQ RRQLRERKQR KLYLEEWSLG 60
DEDGEGTRGF SVAEKLESSK FAQAGMVREM RGCDLTVAFL QQHGFNIPLL FRDKAGLGLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCATATTG AAAAAACCAG CAGAGAGGTC GGATCGCAGC GCTGCTGGAT TTTTCAGCGA 60
TTCGCGTACG GAAAAAATCG AGTACGTCCG AGTGCGGATT GCCCAGAAAT CCGTTTAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC

Pfam

PF12937--F-box-like
PF13516--LRR_6
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00256--FBOX
SM00558--JmjC
SM00367--LRR_CC

Gene Ontology

GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003677--F:DNA binding
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0034647--F:histone demethylase activity (H3-trimethyl-K4 specific)
GO:0008270--F:zinc ion binding
GO:0033522--P:histone H2A ubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0034721--P:histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0007526--P:larval somatic muscle development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007379--P:segment specification
GO:0019233--P:sensory perception of pain
GO:0006351--P:transcription, DNA-templated

KEGG

dme:Dmel_CG11033

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000212	Aegilops tauschii	25.00	9.00e-13	68.20
IUUC-Aml-002052	Ailuropoda melanoleuca	60.00	1.00e-117	417.00
IUUC-Apl-003192	Anas platyrhynchos	57.80	3.00e-123	436.00
IUUC-Aca-004576	Anolis carolinensis	62.15	5.00e-122	431.00
IUUC-Ago-007912	Ashbya gossypii	41.22	4.00e-53	201.00
IUUC-Acl-008303	Aspergillus clavatus	48.45	7.00e-71	262.00
IUUC-Afl-008579	Aspergillus flavus	46.67	2.00e-27	117.00
IUUC-Afu-008903	Aspergillus fumigatus	48.06	1.00e-70	261.00
IUUC-Ani-009279	Aspergillus nidulans	48.25	7.00e-71	262.00
IUUC-Ang-009645	Aspergillus niger	47.29	5.00e-68	252.00
IUUC-Aor-010233	Aspergillus oryzae	49.03	3.00e-70	259.00
IUUC-Ate-010345	Aspergillus terreus	48.25	4.00e-72	266.00
IUUC-Ame-011753	Astyanax mexicanus	49.89	1.00e-130	460.00
IUUC-Bta-013531	Bos taurus	58.41	4.00e-121	428.00
IUUC-Cel-018303	Caenorhabditis elegans	44.10	2.00e-79	290.00
IUUC-Cja-019030	Callithrix jacchus	60.79	5.00e-118	418.00
IUUC-Cfa-020644	Canis familiaris	60.79	6.00e-118	418.00
IUUC-Cpo-022055	Cavia porcellus	59.88	3.00e-116	412.00
IUUC-Csa-023379	Chlorocebus sabaeus	60.79	5.00e-118	418.00
IUUC-Cho-024541	Choloepus hoffmanni	51.32	7.00e-81	295.00
IUUC-Cin-025140	Ciona intestinalis	50.55	5.00e-110	391.00
IUUC-Csv-025861	Ciona savignyi	50.25	5.00e-122	431.00
IUUC-Cne-026797	Cryptococcus neoformans	37.01	1.00e-55	210.00
IUUC-Cme-027118	Cyanidioschyzon merolae	37.14	2.00e-47	183.00
IUUC-Dre-028182	Danio rerio	51.95	4.00e-126	445.00
IUUC-Dno-029268	Dasypus novemcinctus	60.79	6.00e-118	418.00
IUUC-Dor-030736	Dipodomys ordii	56.93	5.00e-116	412.00
IUUC-Dse-031402	Dothistroma septosporum	38.70	8.00e-65	242.00
IUUC-Ete-032467	Echinops telfairi	60.80	1.00e-120	427.00
IUUC-Eca-033526	Equus caballus	60.49	1.00e-117	417.00
IUUC-Eeu-035273	Erinaceus europaeus	65.50	1.00e-79	290.00
IUUC-Fca-035532	Felis catus	60.79	6.00e-118	418.00
IUUC-Fal-037140	Ficedula albicollis	62.15	1.00e-123	437.00
IUUC-Gmo-038932	Gadus morhua	47.64	2.00e-127	449.00
IUUC-Ggr-039983	Gaeumannomyces graminis	25.00	3.00e-06	47.00
IUUC-Gga-040418	Gallus gallus	61.83	1.00e-121	429.00
IUUC-Gac-041674	Gasterosteus aculeatus	58.28	6.00e-121	427.00
IUUC-Ggo-044712	Gorilla gorilla	49.10	2.00e-80	293.00
IUUC-Hsa-046180	Homo sapiens	60.79	3.00e-118	419.00
IUUC-Itr-048198	Ictidomys tridecemlineatus	39.77	7.00e-44	171.00
IUUC-Kpa-049384	Komagataella pastoris	40.86	4.00e-56	211.00
IUUC-Lch-049950	Latimeria chalumnae	57.52	7.00e-120	424.00
IUUC-Loc-051972	Lepisosteus oculatus	55.78	2.00e-114	406.00
IUUC-Lma-053190	Leptosphaeria maculans	39.56	2.00e-61	231.00
IUUC-Laf-053939	Loxodonta africana	60.79	2.00e-118	419.00
IUUC-Mcc-054600	Macaca mulatta	60.79	6.00e-118	418.00
IUUC-Meu-056259	Macropus eugenii	57.36	6.00e-115	408.00
IUUC-Mla-058890	Melampsora laricipopulina	48.25	1.00e-74	272.00
IUUC-Mga-059549	Meleagris gallopavo	61.83	2.00e-122	432.00
IUUC-Mvi-060481	Microbotryum violaceum	40.72	2.00e-70	260.00
IUUC-Mmr-060865	Microcebus murinus	60.79	5.00e-118	418.00
IUUC-Mdo-062567	Monodelphis domestica	60.49	1.00e-117	417.00
IUUC-Mmu-063782	Mus musculus	60.79	4.00e-118	419.00
IUUC-Mpu-066055	Mustela putorius furo	60.79	4.00e-118	418.00
IUUC-Mlu-067228	Myotis lucifugus	60.86	3.00e-119	422.00
IUUC-Nfi-068537	Neosartorya fischeri	48.45	4.00e-71	263.00
IUUC-Nle-069668	Nomascus leucogenys	60.79	4.00e-118	419.00
IUUC-Opr-070225	Ochotona princeps	60.79	8.00e-118	417.00
IUUC-Ont-072151	Oreochromis niloticus	57.23	1.00e-123	436.00
IUUC-Oan-073668	Ornithorhynchus anatinus	57.98	1.00e-103	369.00
IUUC-Ocu-074710	Oryctolagus cuniculus	60.79	5.00e-118	418.00
IUUC-Ola-087196	Oryzias latipes	49.23	3.00e-128	452.00
IUUC-Oga-088644	Otolemur garnettii	62.71	1.00e-113	404.00
IUUC-Oar-089193	Ovis aries	60.12	2.00e-115	409.00
IUUC-Ptr-091523	Pan troglodytes	60.79	3.00e-118	419.00
IUUC-Pan-092415	Papio anubis	60.79	5.00e-118	418.00
IUUC-Psi-093114	Pelodiscus sinensis	61.20	3.00e-121	427.00
IUUC-Pma-094621	Petromyzon marinus	50.72	4.00e-81	294.00
IUUC-Pno-094984	Phaeosphaeria nodorum	44.75	7.00e-63	235.00
IUUC-Ppa-095609	Physcomitrella patens	40.07	1.00e-53	202.00
IUUC-Pfo-096512	Poecilia formosa	57.40	2.00e-120	427.00
IUUC-Pab-097907	Pongo abelii	58.70	8.00e-122	431.00
IUUC-Pca-100628	Procavia capensis	48.97	1.00e-93	337.00
IUUC-Pva-102416	Pteropus vampyrus	60.79	1.00e-117	417.00
IUUC-Pgr-103554	Puccinia graminis	47.49	2.00e-76	279.00
IUUC-Ptt-103859	Puccinia triticina	46.96	3.00e-76	278.00
IUUC-Pte-104241	Pyrenophora teres	44.36	6.00e-62	232.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	44.36	1.00e-61	231.00
IUUC-Rno-105814	Rattus norvegicus	61.09	2.00e-118	420.00
IUUC-Sce-106445	Saccharomyces cerevisiae	40.00	1.00e-51	196.00
IUUC-Sha-106693	Sarcophilus harrisii	60.79	1.00e-117	417.00
IUUC-Sja-107763	Schizosaccharomyces japonicus	31.18	5.00e-45	175.00
IUUC-Spo-108120	Schizosaccharomyces pombe	32.48	1.00e-51	197.00
IUUC-Smo-109024	Selaginella moellendorffii	33.69	3.00e-53	202.00
IUUC-Sar-113568	Sorex araneus	60.31	2.00e-115	409.00
IUUC-Sre-115112	Sporisorium reilianum	40.78	2.00e-58	219.00
IUUC-Ssc-115432	Sus scrofa	61.25	2.00e-116	411.00
IUUC-Tgu-117298	Taeniopygia guttata	61.20	6.00e-122	431.00
IUUC-Tru-118423	Takifugu rubripes	46.49	5.00e-125	441.00
IUUC-Tsy-119293	Tarsius syrichta	58.97	1.00e-112	400.00
IUUC-Tni-120020	Tetraodon nigroviridis	45.40	6.00e-121	428.00
IUUC-Tme-127054	Tuber melanosporum	38.35	2.00e-51	197.00
IUUC-Tbe-128138	Tupaia belangeri	48.38	1.00e-77	284.00
IUUC-Ttr-128837	Tursiops truncatus	52.89	3.00e-95	342.00
IUUC-Uma-129458	Ustilago maydis	40.39	1.00e-58	220.00
IUUC-Vpa-130655	Vicugna pacos	56.53	5.00e-106	378.00
IUUC-Xtr-131839	Xenopus tropicalis	60.49	1.00e-121	429.00
IUUC-Xma-133139	Xiphophorus maculatus	45.92	1.00e-124	440.00
IUUC-Yli-134626	Yarrowia lipolytica	40.27	5.00e-58	218.00
IUUC-Zma-134788	Zea mays	23.70	9.00e-14	70.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence