iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012453

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02028881

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013793.5	ENSBTAT00000018331.5	ENSBTAP00000018331.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.80e-133	443.6	986	1316

Active Site

Position(s)	Description	Evidence
1286	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 986  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1072
           5899**********************************************************************************7 PP
   S: 91   .plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
            ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk+gG++i Vtn+Nk+eY+ l
   Q: 1073 gFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKSGGSEIVVTNKNKKEYIYL 1154
           3679********************************99...6666..79************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           v+++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r +
   Q: 1155 VIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSINHQVIQWFWKAVLMMDSEKRIR 1241
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1242 LLQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1316
           **************************************************************************8 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSS IHMCFTRPTR ISTANVVQMK LTPKQTALAP 60
LIKENLKSRE RSSFPSPENV HKKSSCLQIS LQPTRYSGCL QSGNVLADGD DASFTCVLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA TCCTTTGTCA 60
GAAACCTCCG GAGATGATTT GGATAGCAGC ATTCACATGT GCTTCACGAG ACCAACACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	90.44	0.00e+00	2336.00
IUUC-Apl-003886	Anas platyrhynchos	75.17	0.00e+00	1253.00
IUUC-Ame-011138	Astyanax mexicanus	82.89	0.00e+00	842.00
IUUC-Cja-019034	Callithrix jacchus	90.58	0.00e+00	1364.00
IUUC-Cfa-020258	Canis familiaris	90.59	0.00e+00	2294.00
IUUC-Cpo-021648	Cavia porcellus	87.56	0.00e+00	1428.00
IUUC-Csa-023334	Chlorocebus sabaeus	92.83	0.00e+00	1450.00
IUUC-Cho-024672	Choloepus hoffmanni	82.69	0.00e+00	712.00
IUUC-Dre-027924	Danio rerio	65.04	0.00e+00	877.00
IUUC-Dno-029159	Dasypus novemcinctus	87.80	0.00e+00	1295.00
IUUC-Ete-032409	Echinops telfairi	83.83	0.00e+00	1147.00
IUUC-Eca-033441	Equus caballus	93.08	0.00e+00	1441.00
IUUC-Eeu-034546	Erinaceus europaeus	73.38	0.00e+00	1144.00
IUUC-Fca-036384	Felis catus	91.12	0.00e+00	2339.00
IUUC-Fal-037547	Ficedula albicollis	80.15	0.00e+00	1283.00
IUUC-Gmo-039679	Gadus morhua	67.04	0.00e+00	1063.00
IUUC-Gga-040524	Gallus gallus	81.63	0.00e+00	1303.00
IUUC-Gac-042607	Gasterosteus aculeatus	65.39	0.00e+00	1065.00
IUUC-Hsa-046479	Homo sapiens	90.00	0.00e+00	2316.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	79.05	0.00e+00	1151.00
IUUC-Lch-050445	Latimeria chalumnae	58.81	0.00e+00	1431.00
IUUC-Loc-052645	Lepisosteus oculatus	71.17	0.00e+00	1165.00
IUUC-Laf-053638	Loxodonta africana	83.10	0.00e+00	1318.00
IUUC-Mcc-055585	Macaca mulatta	89.09	0.00e+00	2284.00
IUUC-Meu-056897	Macropus eugenii	94.79	6.00e-170	591.00
IUUC-Mla-058996	Melampsora laricipopulina	46.37	3.00e-153	535.00
IUUC-Mga-059362	Meleagris gallopavo	75.23	0.00e+00	1271.00
IUUC-Mmr-061061	Microcebus murinus	90.29	0.00e+00	2324.00
IUUC-Mdo-062178	Monodelphis domestica	62.34	0.00e+00	1680.00
IUUC-Mmu-063318	Mus musculus	77.28	0.00e+00	1214.00
IUUC-Mpu-066567	Mustela putorius furo	92.62	0.00e+00	1503.00
IUUC-Mlu-068148	Myotis lucifugus	88.94	0.00e+00	2267.00
IUUC-Nle-069225	Nomascus leucogenys	89.69	0.00e+00	2306.00
IUUC-Ont-071664	Oreochromis niloticus	65.26	0.00e+00	1044.00
IUUC-Oan-073019	Ornithorhynchus anatinus	83.58	0.00e+00	1346.00
IUUC-Ocu-074409	Oryctolagus cuniculus	86.26	0.00e+00	2187.00
IUUC-Oga-088241	Otolemur garnettii	85.05	0.00e+00	2079.00
IUUC-Oar-089797	Ovis aries	97.40	0.00e+00	1526.00
IUUC-Ptr-091629	Pan troglodytes	90.85	0.00e+00	1333.00
IUUC-Psi-093618	Pelodiscus sinensis	67.95	0.00e+00	1617.00
IUUC-Pfo-097145	Poecilia formosa	66.07	0.00e+00	1048.00
IUUC-Pab-098394	Pongo abelii	92.34	0.00e+00	1459.00
IUUC-Pca-100568	Procavia capensis	76.49	0.00e+00	1125.00
IUUC-Rno-106095	Rattus norvegicus	77.04	0.00e+00	1213.00
IUUC-Sha-107370	Sarcophilus harrisii	66.69	0.00e+00	1728.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	49.73	7.00e-154	537.00
IUUC-Sre-114929	Sporisorium reilianum	46.93	3.00e-152	532.00
IUUC-Tgu-117474	Taeniopygia guttata	81.26	0.00e+00	1294.00
IUUC-Tru-117675	Takifugu rubripes	64.34	0.00e+00	1049.00
IUUC-Tni-119993	Tetraodon nigroviridis	63.83	0.00e+00	1048.00
IUUC-Tbe-127408	Tupaia belangeri	83.70	0.00e+00	1114.00
IUUC-Ttr-128437	Tursiops truncatus	84.96	0.00e+00	1179.00
IUUC-Vpa-130503	Vicugna pacos	87.92	0.00e+00	1271.00
IUUC-Xtr-132431	Xenopus tropicalis	69.83	0.00e+00	1182.00
IUUC-Xma-133630	Xiphophorus maculatus	62.57	0.00e+00	1018.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence