iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027924

UUCD1 version

UUC-DaR-00972

Ensembl Protein ID

ENSDARP00000132840.1

UniProt Accession

A0A0R4IDE6; A0A0R4IDE6_DANRE

Genbank Protein ID

ENSDARP00000132840

Protein Name

Neural precursor cell-expressed, developmentally down-regulated 4a

Genbank Nucleotide ID

CU928152

Gene Name

nedd4a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000099843.1	ENSDART00000159464.1	ENSDARP00000132840.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.00e-78	263.8	577	785

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           + lk+rl+vef+gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld++
   Q: 577  ELLKARLWVEFEGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAF 665
           56899************************************************************************************ PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           + ++fyk++l+k+++l+d+e+vd+e+++sl +i+en   d ++  ldl+f+++ee++g+t+++eLkpgG++i V+ +Nk+eY++lv+++
   Q: 666  FIRPFYKMMLQKPITLQDMESVDSEYFNSLRWILEN---DPTD--LDLRFTIDEELFGQTHQHELKPGGADIVVNDTNKKEYIHLVMQW 749
           **********************************99...6666..79999999************************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelel 216
           r+ ++i++q++af+eGf+e+ip++l+++F+e+ele+
   Q: 750  RFVDRIQRQMTAFKEGFYELIPQDLIKIFDENELEV 785
           **********************************85 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MNMAAQLPEV RGLQTDEDES RILRVKIIAG IGLAKKDILG ASDPYTRISL YDPVNGEITS 60
LQTKTIKKTL DPKWNEEFFF RVHPRRHRLL LEVFDENRLT RDDFLGQVDV PLHQIPTEHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGACGCC GTGGGGGGCG TGTCGAGGTA GAAGCGCGCT GAAAGGATGT CCAACGGCGT 60
AGTTTCAACG ATGCATTTGA CAAGCTAACG CCTTTCTGCT CGTGACATCT CCGGGGAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012453	Bos taurus	65.67	0.00e+00	873.00
IUUC-Cpo-021648	Cavia porcellus	67.91	0.00e+00	1030.00
IUUC-Csa-023334	Chlorocebus sabaeus	68.77	0.00e+00	1051.00
IUUC-Ete-032409	Echinops telfairi	65.27	0.00e+00	751.00
IUUC-Fal-037547	Ficedula albicollis	68.09	0.00e+00	1026.00
IUUC-Gmo-039679	Gadus morhua	72.94	0.00e+00	1102.00
IUUC-Gga-040524	Gallus gallus	67.64	0.00e+00	1039.00
IUUC-Gac-042607	Gasterosteus aculeatus	71.86	0.00e+00	1114.00
IUUC-Loc-052645	Lepisosteus oculatus	77.05	0.00e+00	1169.00
IUUC-Lma-052980	Leptosphaeria maculans	43.54	8.00e-86	311.00
IUUC-Mmu-063318	Mus musculus	62.68	0.00e+00	923.00
IUUC-Ont-071664	Oreochromis niloticus	69.77	0.00e+00	1077.00
IUUC-Ocu-074409	Oryctolagus cuniculus	67.58	0.00e+00	922.00
IUUC-Oar-089797	Ovis aries	67.39	0.00e+00	971.00
IUUC-Psi-093618	Pelodiscus sinensis	67.68	0.00e+00	909.00
IUUC-Pfo-097145	Poecilia formosa	69.74	0.00e+00	1042.00
IUUC-Pab-098394	Pongo abelii	68.95	0.00e+00	1035.00
IUUC-Rno-106095	Rattus norvegicus	62.11	0.00e+00	922.00
IUUC-Sha-107370	Sarcophilus harrisii	66.04	0.00e+00	923.00
IUUC-Sar-113715	Sorex araneus	75.38	6.00e-116	412.00
IUUC-Tgu-117474	Taeniopygia guttata	68.31	0.00e+00	1047.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence