iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053845

Ensembl Protein ID

ENSLAFP00000011326.3

UniProt Accession

G3TBH2; G3TBH2_LOXAF

Protein Name

Uncharacterized protein

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000013540.3	ENSLAFT00000013538.3	ENSLAFP00000011326.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-46	154.5	192	249

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ 
   Q: 192  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMIGLVPKNYVTI 249
           689**************************************.59*************85 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGAAG AAGTGGTGGT AGTAGCCAAA TTTGATTATG TGGCCCAACA AGAACAAGAG 60
CTGGACATTA AGAAGAATGA AAGATTGTGG CTTCTGGATG ATTCTAAGTC CTGGTGGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

KEGG

lav:100666870

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	98.41	0.00e+00	734.00
IUUC-Ame-011235	Astyanax mexicanus	77.84	2.00e-180	624.00
IUUC-Bta-013039	Bos taurus	98.41	0.00e+00	735.00
IUUC-Cja-019546	Callithrix jacchus	98.14	0.00e+00	729.00
IUUC-Cfa-020462	Canis familiaris	98.67	0.00e+00	737.00
IUUC-Cpo-022009	Cavia porcellus	97.88	0.00e+00	731.00
IUUC-Csa-023875	Chlorocebus sabaeus	98.94	0.00e+00	737.00
IUUC-Cho-024368	Choloepus hoffmanni	96.80	0.00e+00	647.00
IUUC-Csv-026046	Ciona savignyi	40.60	9.00e-72	263.00
IUUC-Dre-028407	Danio rerio	77.04	7.00e-178	616.00
IUUC-Dno-029593	Dasypus novemcinctus	98.40	5.00e-174	603.00
IUUC-Dor-030730	Dipodomys ordii	97.12	0.00e+00	640.00
IUUC-Dme-031846	Drosophila melanogaster	43.10	8.00e-92	330.00
IUUC-Ete-032906	Echinops telfairi	98.41	0.00e+00	728.00
IUUC-Eca-033378	Equus caballus	98.78	0.00e+00	639.00
IUUC-Eeu-034743	Erinaceus europaeus	87.80	0.00e+00	672.00
IUUC-Fca-035745	Felis catus	98.41	0.00e+00	776.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.58	6.00e-159	553.00
IUUC-Ggo-045487	Gorilla gorilla	98.94	0.00e+00	737.00
IUUC-Hsa-045902	Homo sapiens	98.94	0.00e+00	737.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	98.67	0.00e+00	736.00
IUUC-Lch-050165	Latimeria chalumnae	81.96	6.00e-180	622.00
IUUC-Loc-052523	Lepisosteus oculatus	78.36	1.00e-179	622.00
IUUC-Meu-056139	Macropus eugenii	90.98	0.00e+00	664.00
IUUC-Mmr-061108	Microcebus murinus	87.27	3.00e-174	603.00
IUUC-Mdo-062258	Monodelphis domestica	93.90	0.00e+00	709.00
IUUC-Mmu-063970	Mus musculus	98.41	0.00e+00	777.00
IUUC-Mpu-066093	Mustela putorius furo	98.67	0.00e+00	736.00
IUUC-Mlu-067193	Myotis lucifugus	98.41	0.00e+00	734.00
IUUC-Nle-069611	Nomascus leucogenys	98.94	0.00e+00	737.00
IUUC-Opr-070984	Ochotona princeps	97.01	2.00e-178	617.00
IUUC-Ont-072241	Oreochromis niloticus	75.38	3.00e-171	594.00
IUUC-Oan-072976	Ornithorhynchus anatinus	88.93	3.00e-166	577.00
IUUC-Ocu-073905	Oryctolagus cuniculus	98.94	0.00e+00	737.00
IUUC-Ola-086513	Oryzias latipes	74.87	8.00e-160	556.00
IUUC-Oga-088588	Otolemur garnettii	99.47	0.00e+00	739.00
IUUC-Oar-089973	Ovis aries	98.67	0.00e+00	736.00
IUUC-Ptr-090968	Pan troglodytes	98.94	0.00e+00	737.00
IUUC-Pan-092840	Papio anubis	98.72	7.00e-175	605.00
IUUC-Pfo-096057	Poecilia formosa	74.23	1.00e-169	588.00
IUUC-Pab-097807	Pongo abelii	98.67	0.00e+00	737.00
IUUC-Pca-100522	Procavia capensis	99.04	8.00e-175	605.00
IUUC-Pva-103083	Pteropus vampyrus	98.67	0.00e+00	735.00
IUUC-Rno-104839	Rattus norvegicus	95.49	0.00e+00	739.00
IUUC-Sha-107294	Sarcophilus harrisii	93.37	0.00e+00	702.00
IUUC-Sar-113675	Sorex araneus	96.82	0.00e+00	721.00
IUUC-Ssc-116442	Sus scrofa	97.61	0.00e+00	769.00
IUUC-Tru-118058	Takifugu rubripes	74.30	2.00e-168	584.00
IUUC-Tsy-119184	Tarsius syrichta	91.39	0.00e+00	629.00
IUUC-Tni-119974	Tetraodon nigroviridis	74.23	1.00e-156	545.00
IUUC-Ttr-129155	Tursiops truncatus	96.82	0.00e+00	733.00
IUUC-Vpa-130344	Vicugna pacos	98.41	0.00e+00	736.00
IUUC-Xtr-132372	Xenopus tropicalis	86.97	0.00e+00	655.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence