iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000166436.15	ENST00000402157.6	ENSP00000384876.2
ENSG00000166436.15	ENST00000530502.1	ENSP00000437234.1
ENSG00000166436.15	ENST00000299550.10	ENSP00000299550.6

Annotation

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRcode
RAID2
Protein-protein Interaction
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.40e-08	35.7	1000	1045

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C+vC +gge    l++C++C ++fH  C+ ++   ++p+ e w C+ Crs
   Q: 1000 DFCAVCLNGGE----LLCCDRCPKVFHLSCHVPA-LLSFPGGE-WVCTLCRS 1045
           79*********....*******************.*******8.******96 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG SPGVNGGPGD 60
FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRHVE EVLQNQRMLL EGVTTQVAHK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGCTCCG TAAGGACTGC TTCCAGGGCT TGATACAGGA GCTAGGGCAG ATTGCCAAGG 60
CTCATGAGAC TGTTGCAGAT GGTAAGTACA AAGGCACCAC AAGTTCACCT CCCACTACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD

Gene Ontology

GO:0016235--C:aggresome
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001710	Ailuropoda melanoleuca	86.31	0.00e+00	1987.00
IUUC-Bta-012888	Bos taurus	86.91	0.00e+00	2012.00
IUUC-Cfa-020643	Canis familiaris	85.03	0.00e+00	1884.00
IUUC-Cpo-022104	Cavia porcellus	85.12	0.00e+00	1950.00
IUUC-Ete-032879	Echinops telfairi	70.60	0.00e+00	661.00
IUUC-Eca-034225	Equus caballus	88.15	0.00e+00	2026.00
IUUC-Fca-035738	Felis catus	87.79	0.00e+00	2004.00
IUUC-Gmo-039050	Gadus morhua	62.44	1.00e-70	261.00
IUUC-Ggo-045431	Gorilla gorilla	87.30	0.00e+00	1201.00
IUUC-Laf-053738	Loxodonta africana	87.81	0.00e+00	2027.00
IUUC-Mcc-055594	Macaca mulatta	94.95	0.00e+00	2178.00
IUUC-Mmr-060590	Microcebus murinus	89.09	0.00e+00	2004.00
IUUC-Mdo-062447	Monodelphis domestica	61.01	0.00e+00	636.00
IUUC-Mpu-066171	Mustela putorius furo	87.11	0.00e+00	1993.00
IUUC-Mlu-067335	Myotis lucifugus	79.57	0.00e+00	1048.00
IUUC-Nle-069006	Nomascus leucogenys	94.15	0.00e+00	2117.00
IUUC-Opr-071210	Ochotona princeps	74.04	0.00e+00	902.00
IUUC-Ont-072494	Oreochromis niloticus	55.79	1.00e-67	251.00
IUUC-Ocu-074494	Oryctolagus cuniculus	86.70	0.00e+00	1999.00
IUUC-Oga-088638	Otolemur garnettii	88.27	0.00e+00	1966.00
IUUC-Oar-090199	Ovis aries	82.30	0.00e+00	1876.00
IUUC-Pan-092538	Papio anubis	94.07	0.00e+00	1865.00
IUUC-Psi-093917	Pelodiscus sinensis	57.84	2.00e-142	499.00
IUUC-Pca-100445	Procavia capensis	83.60	0.00e+00	1823.00
IUUC-Sha-107427	Sarcophilus harrisii	59.00	0.00e+00	1120.00
IUUC-Sar-113354	Sorex araneus	80.83	0.00e+00	1754.00
IUUC-Ssc-116315	Sus scrofa	78.32	0.00e+00	1617.00
IUUC-Tbe-128083	Tupaia belangeri	72.93	0.00e+00	669.00
IUUC-Ttr-128925	Tursiops truncatus	83.00	0.00e+00	712.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence