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Tag Content
iUUCD ID IUUC-Gac-042511
Ensembl Protein ID ENSGACP00000026286.1
UniProt Accession G3Q8S2; G3Q8S2_GASAC
Protein Name Presenilin
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGACG00000019890.1 ENSGACT00000026333.1 ENSGACP00000026282.1
ENSGACG00000019890.1 ENSGACT00000026337.1 ENSGACP00000026286.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 50.61 2.00e-83 306.00 IUUC-Cel-018553
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Gasterosteus aculeatus
Functional Description
(View)

Functional Description


     Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Protein Sequence
(Fasta)
MNASDSEEDS YDERTALVPS ENPVLPSYRP EPDLNPPLDP PTKRFGVSGR AGTAPVDGGG 60
GGSDQEADVD EEELTLKYGA KHVIMLFIPV TLCMLVVVVT IKSVSFYTEK TNQTLIYTPF 120
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Protein Fasta Sequence


>IUUC-Gac-042511|UBD,CUE|Gasterosteus aculeatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGTTTACTT TGTGAGCGGC TCGTCTCTGT TCCTGCGAGT AAAGCTTCTC TGTGTGAGTA 60
TATATGTACA AATACCTCTC TATGTATGTA TATTTATATT TATATACATT TACTCACACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gac-042511|UBD,CUE|Gasterosteus aculeatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
SMART

SM00730--PSN
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000686 Aegilops tauschii 60.00 3.00e-15 77.40
IUUC-Aml-002356 Ailuropoda melanoleuca 58.66 6.00e-108 384.00
IUUC-Atr-003039 Amborella trichopoda 31.36 2.00e-38 153.00
IUUC-Apl-003959 Anas platyrhynchos 65.42 8.00e-138 483.00
IUUC-Aca-005160 Anolis carolinensis 67.61 1.00e-145 509.00
IUUC-Ame-010686 Astyanax mexicanus 75.54 7.00e-152 530.00
IUUC-Bta-013097 Bos taurus 64.27 4.00e-133 467.00
IUUC-Bdi-014196 Brachypodium distachyon 33.61 2.00e-34 140.00
IUUC-Bol-015841 Brassica oleracea 33.17 3.00e-31 129.00
IUUC-Bra-017580 Brassica rapa 52.83 3.00e-18 85.90
IUUC-Cel-018553 Caenorhabditis elegans 49.30 6.00e-95 341.00
IUUC-Cfa-020253 Canis familiaris 65.18 8.00e-134 470.00
IUUC-Cpo-021401 Cavia porcellus 64.36 1.00e-134 473.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 33.65 4.00e-30 125.00
IUUC-Csa-023369 Chlorocebus sabaeus 64.93 6.00e-135 473.00
IUUC-Cin-025780 Ciona intestinalis 60.29 1.00e-117 416.00
IUUC-Csv-025967 Ciona savignyi 61.65 5.00e-122 431.00
IUUC-Dre-028526 Danio rerio 70.04 1.00e-151 529.00
IUUC-Dor-031127 Dipodomys ordii 65.14 1.00e-129 456.00
IUUC-Dme-031929 Drosophila melanogaster 53.27 2.00e-109 389.00
IUUC-Ete-033081 Echinops telfairi 58.25 1.00e-59 223.00
IUUC-Eca-034387 Equus caballus 65.55 4.00e-129 454.00
IUUC-Fca-035396 Felis catus 66.88 7.00e-141 493.00
IUUC-Fal-037457 Ficedula albicollis 67.67 3.00e-136 478.00
IUUC-Gmo-038550 Gadus morhua 72.54 2.00e-139 488.00
IUUC-Gga-040706 Gallus gallus 66.60 5.00e-136 477.00
IUUC-Gma-043822 Glycine max 35.88 1.00e-21 97.80
IUUC-Ggo-045338 Gorilla gorilla 64.93 7.00e-135 473.00
IUUC-Hsa-046455 Homo sapiens 64.93 7.00e-135 473.00
IUUC-Hvu-047141 Hordeum vulgare 61.25 5.00e-16 79.00
IUUC-Itr-048731 Ictidomys tridecemlineatus 64.97 2.00e-134 472.00
IUUC-Lch-049638 Latimeria chalumnae 60.88 4.00e-127 448.00
IUUC-Lpe-051132 Leersia perrieri 48.36 6.00e-17 82.00
IUUC-Loc-052427 Lepisosteus oculatus 70.47 3.00e-152 531.00
IUUC-Laf-053758 Loxodonta africana 66.04 1.00e-145 509.00
IUUC-Mcc-054755 Macaca mulatta 64.93 1.00e-134 473.00
IUUC-Meu-056004 Macropus eugenii 57.83 1.00e-96 346.00
IUUC-Mtr-058392 Medicago truncatula 32.26 3.00e-30 125.00
IUUC-Mmr-060890 Microcebus murinus 64.30 9.00e-134 469.00
IUUC-Mdo-062197 Monodelphis domestica 67.81 3.00e-139 488.00
IUUC-Mmu-063823 Mus musculus 65.76 3.00e-136 478.00
IUUC-Mac-064858 Musa acuminata 39.57 6.00e-20 91.30
IUUC-Mpu-066181 Mustela putorius furo 65.18 1.00e-134 473.00
IUUC-Opr-070344 Ochotona princeps 65.76 1.00e-139 489.00
IUUC-Ont-071867 Oreochromis niloticus 81.00 5.00e-165 573.00
IUUC-Oan-073378 Ornithorhynchus anatinus 63.59 4.00e-125 441.00
IUUC-Ocu-074652 Oryctolagus cuniculus 63.75 9.00e-134 470.00
IUUC-Oba-075256 Oryza barthii 61.45 1.00e-16 80.90
IUUC-Obr-076302 Oryza brachyantha 56.31 1.00e-17 84.70
IUUC-Ogl-077097 Oryza glaberrima 61.45 1.00e-16 80.90
IUUC-Ogu-078570 Oryza glumaepatula 61.45 1.00e-16 80.50
IUUC-Oin-079244 Oryza indica 61.45 1.00e-16 80.90
IUUC-Olo-080484 Oryza longistaminata 61.45 5.00e-17 81.30
IUUC-Ome-081814 Oryza meridionalis 61.45 1.00e-16 81.30
IUUC-Oni-082057 Oryza nivara 61.45 2.00e-16 80.50
IUUC-Opu-084176 Oryza punctata 34.27 2.00e-31 130.00
IUUC-Oru-084618 Oryza rufipogon 61.45 1.00e-16 80.50
IUUC-Osa-085602 Oryza sativa 61.45 1.00e-16 80.50
IUUC-Ola-086707 Oryzias latipes 79.87 1.00e-121 429.00
IUUC-Olu-087811 Ostreococcus lucimarinus 35.71 1.00e-47 183.00
IUUC-Oga-088560 Otolemur garnettii 65.83 2.00e-134 472.00
IUUC-Oar-089200 Ovis aries 64.74 2.00e-132 465.00
IUUC-Ptr-090569 Pan troglodytes 65.14 9.00e-136 476.00
IUUC-Pan-091742 Papio anubis 64.93 8.00e-135 473.00
IUUC-Pma-094612 Petromyzon marinus 72.85 4.00e-116 411.00
IUUC-Ppa-095431 Physcomitrella patens 31.30 8.00e-28 118.00
IUUC-Pab-098531 Pongo abelii 64.93 6.00e-135 473.00
IUUC-Pop-099661 Populus trichocarpa 32.06 1.00e-36 147.00
IUUC-Pca-101120 Procavia capensis 63.05 2.00e-128 452.00
IUUC-Ppe-101495 Prunus persica 30.16 1.00e-37 150.00
IUUC-Pva-102934 Pteropus vampyrus 62.85 9.00e-134 470.00
IUUC-Rno-106052 Rattus norvegicus 66.24 4.00e-140 491.00
IUUC-Sha-106876 Sarcophilus harrisii 66.03 2.00e-136 478.00
IUUC-Smo-109325 Selaginella moellendorffii 36.54 3.00e-34 139.00
IUUC-Sit-110624 Setaria italica 59.04 4.00e-16 79.30
IUUC-Sly-110865 Solanum lycopersicum 55.56 3.00e-07 46.60
IUUC-Stu-112433 Solanum tuberosum 32.13 3.00e-29 122.00
IUUC-Sbi-114305 Sorghum bicolor 53.47 1.00e-16 80.90
IUUC-Ssc-115380 Sus scrofa 65.18 2.00e-139 488.00
IUUC-Tgu-117280 Taeniopygia guttata 67.45 9.00e-137 479.00
IUUC-Tca-121865 Theobroma cacao 32.84 4.00e-37 149.00
IUUC-Tae-125925 Triticum aestivum 33.90 1.00e-28 120.00
IUUC-Tur-126237 Triticum urartu 61.25 5.00e-16 79.00
IUUC-Tbe-127632 Tupaia belangeri 64.83 1.00e-111 396.00
IUUC-Ttr-129008 Tursiops truncatus 64.76 5.00e-133 467.00
IUUC-Vvi-131312 Vitis vinifera 31.15 3.00e-32 132.00
IUUC-Xtr-132756 Xenopus tropicalis 67.52 4.00e-152 531.00
Created Date 25-Jun-2017

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