iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066181

Ensembl Protein ID

ENSMPUP00000015742.1

UniProt Accession

M3YWN2; M3YWN2_MUSPF

Genbank Protein ID

ENSMPUP00000015742

Protein Name

Presenilin

Genbank Nucleotide ID

AEYP01042215

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000015849.1	ENSMPUT00000015983.1	ENSMPUP00000015742.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.10e-08	33.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Mustela putorius furo

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPPPRC CQEARQGLED RESAAQWRSQ DSEEDLDEDA 60
DRYMCSGVPG QPSGLEEELT LKYGAKHVIM LFVPVTLCMV VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGACCGG GGCGGGGTCT GCGCCGGCGC TGGGGTCCGG GAGGGACGGG CGCTCGGCCA 60
GCGGCGTAAA CACCGCCGCA GCGCCGCTGC GGAGCAGGTG AGCTGGCTGG TCTGGGGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	91.29	0.00e+00	645.00
IUUC-Apl-003959	Anas platyrhynchos	77.20	5.00e-163	566.00
IUUC-Aca-005160	Anolis carolinensis	74.78	5.00e-160	557.00
IUUC-Ame-010686	Astyanax mexicanus	79.43	7.00e-148	516.00
IUUC-Bta-013097	Bos taurus	95.55	0.00e+00	720.00
IUUC-Cja-018824	Callithrix jacchus	93.97	0.00e+00	720.00
IUUC-Cfa-020253	Canis familiaris	97.99	0.00e+00	761.00
IUUC-Cpo-021401	Cavia porcellus	94.87	0.00e+00	729.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.56	5.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.54	0.00e+00	738.00
IUUC-Dre-028526	Danio rerio	70.34	1.00e-143	503.00
IUUC-Dor-031127	Dipodomys ordii	90.62	0.00e+00	679.00
IUUC-Ete-033081	Echinops telfairi	84.40	2.00e-94	339.00
IUUC-Eca-034387	Equus caballus	94.42	0.00e+00	689.00
IUUC-Eeu-034846	Erinaceus europaeus	79.41	1.00e-147	516.00
IUUC-Fca-035396	Felis catus	96.87	0.00e+00	774.00
IUUC-Fal-037457	Ficedula albicollis	76.74	3.00e-161	561.00
IUUC-Gmo-038550	Gadus morhua	82.76	1.00e-105	376.00
IUUC-Gga-040706	Gallus gallus	77.14	8.00e-160	556.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.32	9.00e-131	459.00
IUUC-Ggo-045338	Gorilla gorilla	95.54	0.00e+00	737.00
IUUC-Hsa-046455	Homo sapiens	95.54	0.00e+00	738.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.54	0.00e+00	738.00
IUUC-Lch-049638	Latimeria chalumnae	67.88	3.00e-145	508.00
IUUC-Loc-052427	Lepisosteus oculatus	73.46	8.00e-156	543.00
IUUC-Laf-053758	Loxodonta africana	89.36	0.00e+00	721.00
IUUC-Mcc-054755	Macaca mulatta	95.54	0.00e+00	737.00
IUUC-Mmr-060890	Microcebus murinus	94.20	0.00e+00	723.00
IUUC-Mdo-062197	Monodelphis domestica	79.78	2.00e-179	621.00
IUUC-Mmu-063823	Mus musculus	94.20	0.00e+00	732.00
IUUC-Mac-064858	Musa acuminata	43.27	5.00e-23	101.00
IUUC-Nle-069596	Nomascus leucogenys	94.94	0.00e+00	688.00
IUUC-Opr-070344	Ochotona princeps	92.86	0.00e+00	737.00
IUUC-Ont-071867	Oreochromis niloticus	70.16	1.00e-132	466.00
IUUC-Oan-073378	Ornithorhynchus anatinus	73.49	4.00e-152	531.00
IUUC-Ocu-074652	Oryctolagus cuniculus	93.97	0.00e+00	696.00
IUUC-Ola-086707	Oryzias latipes	66.98	4.00e-106	377.00
IUUC-Oga-088560	Otolemur garnettii	94.24	0.00e+00	692.00
IUUC-Oar-089200	Ovis aries	94.65	0.00e+00	691.00
IUUC-Ptr-090569	Pan troglodytes	95.31	0.00e+00	736.00
IUUC-Pan-091742	Papio anubis	95.54	0.00e+00	738.00
IUUC-Psi-093297	Pelodiscus sinensis	75.65	1.00e-132	465.00
IUUC-Pma-094612	Petromyzon marinus	77.57	1.00e-127	449.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	2.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	95.54	0.00e+00	738.00
IUUC-Pca-101120	Procavia capensis	91.96	0.00e+00	702.00
IUUC-Pva-102934	Pteropus vampyrus	86.61	0.00e+00	697.00
IUUC-Rno-106052	Rattus norvegicus	92.86	0.00e+00	739.00
IUUC-Sha-106876	Sarcophilus harrisii	79.19	6.00e-177	613.00
IUUC-Spo-108191	Schizosaccharomyces pombe	37.84	5.40e-02	32.70
IUUC-Ssc-115380	Sus scrofa	96.88	0.00e+00	769.00
IUUC-Tgu-117280	Taeniopygia guttata	77.39	2.00e-162	565.00
IUUC-Tbe-127632	Tupaia belangeri	94.12	5.00e-178	617.00
IUUC-Ttr-129008	Tursiops truncatus	94.64	0.00e+00	724.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence