iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111719

Ensembl Protein ID

Solyc06g083230.2.1

UniProt Accession

Q8VYU3; GCH1_SOLLC

Genbank Protein ID

AAL49957.1

Protein Name

GTP cyclohydrolase 1; GTP cyclohydrolase I

Genbank Nucleotide ID

AY069920

Gene Name

GCH1; GCHI; Solyc06g083230; LOC543831

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc06g083230.2	Solyc06g083230.2.1	Solyc06g083230.2.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	38.36	3.00e-26	117.00	IUUC-Hsa-046907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Solanum lycopersicum

Functional Description
(View)

GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.

Protein Sequence
(Fasta)

MGALDEGHYH AEIDNEVSFE LGFETQPETL VIQDAVRVLL QGLGEDINRE GIKKTPFRVA 60
KALRQGTRGY KQKVNDIVHG ALFPEAGLEG GSGQAGGVGG LVIVRDLDLF SYCESCLLPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGAAAAC ATTTTTTTAA ATACTGCAAA GTTGTTGTAG TAATGCATAT GCATCTCATC 60
TCCAGATCCC TATAGTATAT GTTCATCAAC AGCAGCCCTA CAAATCCCTT TTCATCCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0783--Tetrahydrobiopterin biosynthesis
KW-0862--Zinc

Interpro

IPR001474--GTP_CycHdrlase_I
IPR020602--GTP_CycHdrlase_I_dom

Pfam

PF01227--GTP_cyclohydroI

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0006729--P:tetrahydrobiopterin biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process

KEGG

sly:543831

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002530	Amborella trichopoda	54.45	9.00e-133	466.00
IUUC-Apl-004135	Anas platyrhynchos	39.55	2.00e-27	114.00
IUUC-Aca-005252	Anolis carolinensis	36.65	2.00e-31	127.00
IUUC-Aly-006454	Arabidopsis lyrata	60.98	1.00e-149	522.00
IUUC-Ath-006744	Arabidopsis thaliana	62.58	3.00e-150	523.00
IUUC-Ago-007744	Ashbya gossypii	42.95	4.00e-30	123.00
IUUC-Acl-008058	Aspergillus clavatus	44.00	1.00e-32	132.00
IUUC-Afl-008668	Aspergillus flavus	42.86	1.00e-33	136.00
IUUC-Afu-008935	Aspergillus fumigatus	44.00	2.00e-32	132.00
IUUC-Ani-009207	Aspergillus nidulans	46.00	4.00e-34	137.00
IUUC-Ang-009686	Aspergillus niger	44.67	6.00e-33	133.00
IUUC-Aor-010202	Aspergillus oryzae	42.86	7.00e-34	136.00
IUUC-Ate-010518	Aspergillus terreus	44.67	9.00e-33	133.00
IUUC-Ame-010958	Astyanax mexicanus	37.69	3.00e-33	134.00
IUUC-Bgr-012060	Blumeria graminis	44.44	9.00e-34	136.00
IUUC-Bta-012416	Bos taurus	40.41	1.00e-30	125.00
IUUC-Bci-013811	Botrytis cinerea	45.33	1.00e-32	132.00
IUUC-Bdi-014794	Brachypodium distachyon	54.87	6.00e-113	400.00
IUUC-Bol-015182	Brassica oleracea	62.25	1.00e-150	525.00
IUUC-Bra-016764	Brassica rapa	61.64	7.00e-148	516.00
IUUC-Cel-018345	Caenorhabditis elegans	36.14	7.00e-34	135.00
IUUC-Cja-019848	Callithrix jacchus	44.74	4.00e-23	99.40
IUUC-Cfa-020630	Canis familiaris	40.41	8.00e-31	126.00
IUUC-Cpo-021420	Cavia porcellus	39.72	3.00e-29	120.00
IUUC-Cre-022618	Chlamydomonas reinhardtii	46.90	1.00e-29	122.00
IUUC-Csa-023403	Chlorocebus sabaeus	33.89	3.00e-20	90.90
IUUC-Cho-024907	Choloepus hoffmanni	41.78	2.00e-31	128.00
IUUC-Cin-025120	Ciona intestinalis	35.53	4.00e-28	117.00
IUUC-Csv-026259	Ciona savignyi	36.55	5.00e-33	132.00
IUUC-Cgl-026508	Colletotrichum gloeosporioides	43.79	4.00e-32	130.00
IUUC-Cne-026810	Cryptococcus neoformans	42.86	1.00e-32	133.00
IUUC-Cme-027139	Cyanidioschyzon merolae	36.60	1.00e-26	112.00
IUUC-Dre-028815	Danio rerio	40.52	1.00e-31	129.00
IUUC-Dno-029017	Dasypus novemcinctus	41.10	1.00e-30	125.00
IUUC-Dor-030417	Dipodomys ordii	44.74	3.00e-23	99.40
IUUC-Dse-031187	Dothistroma septosporum	39.42	1.00e-34	139.00
IUUC-Dme-031615	Drosophila melanogaster	42.19	2.00e-25	108.00
IUUC-Ete-032727	Echinops telfairi	28.67	5.00e-14	70.10
IUUC-Eca-033487	Equus caballus	44.74	4.00e-23	99.40
IUUC-Eeu-034696	Erinaceus europaeus	40.43	3.00e-29	120.00
IUUC-Fca-035975	Felis catus	47.89	5.00e-14	67.80
IUUC-Fal-037439	Ficedula albicollis	38.98	2.00e-23	100.00
IUUC-Fox-037781	Fusarium oxysporum	45.33	5.00e-32	130.00
IUUC-Fso-038377	Fusarium solani	45.75	3.00e-32	131.00
IUUC-Gmo-038945	Gadus morhua	43.51	1.00e-33	135.00
IUUC-Ggr-039834	Gaeumannomyces graminis	41.29	7.00e-34	136.00
IUUC-Gga-040495	Gallus gallus	37.14	1.00e-30	125.00
IUUC-Gac-042306	Gasterosteus aculeatus	42.00	2.00e-32	131.00
IUUC-Gma-043539	Glycine max	63.06	1.00e-161	561.00
IUUC-Ggo-045597	Gorilla gorilla	35.23	5.00e-20	90.10
IUUC-Hsa-046907	Homo sapiens	39.72	1.00e-28	119.00
IUUC-Hvu-047298	Hordeum vulgare	54.95	8.00e-127	446.00
IUUC-Itr-048997	Ictidomys tridecemlineatus	39.73	1.00e-30	125.00
IUUC-Kpa-049319	Komagataella pastoris	35.64	7.00e-31	126.00
IUUC-Lch-049771	Latimeria chalumnae	43.51	7.00e-35	139.00
IUUC-Lpe-050904	Leersia perrieri	56.39	2.00e-124	438.00
IUUC-Loc-052063	Lepisosteus oculatus	42.00	4.00e-34	137.00
IUUC-Lma-053280	Leptosphaeria maculans	34.92	3.00e-23	102.00
IUUC-Laf-054214	Loxodonta africana	40.41	8.00e-31	126.00
IUUC-Mcc-054778	Macaca mulatta	39.72	1.00e-28	119.00
IUUC-Meu-056598	Macropus eugenii	48.44	9.00e-11	59.70
IUUC-Mor-056989	Magnaporthe oryzae	41.29	5.00e-34	137.00
IUUC-Mpo-057591	Magnaporthe poae	40.80	8.00e-34	136.00
IUUC-Mtr-057924	Medicago truncatula	63.36	3.00e-167	580.00
IUUC-Mla-058931	Melampsora laricipopulina	43.14	2.00e-32	132.00
IUUC-Mga-060001	Meleagris gallopavo	43.86	1.00e-22	97.80
IUUC-Mvi-060513	Microbotryum violaceum	44.17	1.00e-33	136.00
IUUC-Mmr-061725	Microcebus murinus	40.41	7.00e-31	126.00
IUUC-Mdo-062715	Monodelphis domestica	40.00	1.00e-30	126.00
IUUC-Mmu-063203	Mus musculus	39.72	2.00e-29	121.00
IUUC-Mac-065392	Musa acuminata	66.88	4.00e-44	170.00
IUUC-Mpu-066174	Mustela putorius furo	40.41	5.00e-31	126.00
IUUC-Mlu-067883	Myotis lucifugus	44.74	4.00e-23	99.40
IUUC-Nfi-068317	Neosartorya fischeri	44.00	1.00e-32	132.00
IUUC-Ncr-068822	Neurospora crassa	46.41	2.00e-34	138.00
IUUC-Nle-069231	Nomascus leucogenys	39.72	1.00e-28	119.00
IUUC-Opr-070417	Ochotona princeps	44.74	3.00e-23	99.40
IUUC-Ont-072168	Oreochromis niloticus	40.67	7.00e-32	129.00
IUUC-Oan-072690	Ornithorhynchus anatinus	47.89	5.00e-14	68.20
IUUC-Ocu-074537	Oryctolagus cuniculus	40.41	2.00e-30	125.00
IUUC-Oba-075333	Oryza barthii	54.05	5.00e-129	453.00
IUUC-Obr-076255	Oryza brachyantha	50.43	1.00e-53	202.00
IUUC-Ogl-077792	Oryza glaberrima	61.88	4.00e-70	256.00
IUUC-Ogu-078354	Oryza glumaepatula	56.95	4.00e-128	451.00
IUUC-Oin-079934	Oryza indica	56.95	6.00e-127	446.00
IUUC-Olo-080643	Oryza longistaminata	56.05	2.00e-114	404.00
IUUC-Ome-081632	Oryza meridionalis	57.34	2.00e-128	452.00
IUUC-Oni-083004	Oryza nivara	56.95	3.00e-127	447.00
IUUC-Opu-083899	Oryza punctata	57.53	1.00e-129	456.00
IUUC-Oru-084386	Oryza rufipogon	56.95	3.00e-127	447.00
IUUC-Osa-085665	Oryza sativa	53.89	4.00e-97	347.00
IUUC-Ola-086577	Oryzias latipes	42.86	6.00e-34	136.00
IUUC-Olu-087867	Ostreococcus lucimarinus	37.58	8.00e-26	108.00
IUUC-Oga-088652	Otolemur garnettii	39.72	2.00e-28	118.00
IUUC-Oar-089965	Ovis aries	40.41	4.00e-31	127.00
IUUC-Ptr-090833	Pan troglodytes	39.72	1.00e-28	119.00
IUUC-Psi-093542	Pelodiscus sinensis	38.10	3.00e-27	114.00
IUUC-Pma-094423	Petromyzon marinus	40.00	8.00e-22	95.10
IUUC-Pno-095091	Phaeosphaeria nodorum	47.33	9.00e-35	139.00
IUUC-Ppa-096013	Physcomitrella patens	39.75	6.00e-88	317.00
IUUC-Pfo-097146	Poecilia formosa	41.33	4.00e-32	130.00
IUUC-Pab-098744	Pongo abelii	39.72	1.00e-28	119.00
IUUC-Pop-099917	Populus trichocarpa	69.11	1.00e-175	608.00
IUUC-Pca-100111	Procavia capensis	40.41	7.00e-31	126.00
IUUC-Ppe-101984	Prunus persica	69.59	0.00e+00	650.00
IUUC-Pva-103078	Pteropus vampyrus	40.41	8.00e-29	119.00
IUUC-Pgr-103438	Puccinia graminis	43.33	3.00e-29	121.00
IUUC-Ptt-103875	Puccinia triticina	42.33	3.00e-31	128.00
IUUC-Pte-104180	Pyrenophora teres	48.67	8.00e-35	140.00
IUUC-Pyt-104552	Pyrenophora triticirepentis	48.67	5.00e-35	140.00
IUUC-Rno-105506	Rattus norvegicus	35.71	2.00e-30	125.00
IUUC-Sce-106375	Saccharomyces cerevisiae	42.86	4.00e-32	130.00
IUUC-Sha-107585	Sarcophilus harrisii	44.74	6.00e-23	98.60
IUUC-Sja-107871	Schizosaccharomyces japonicus	42.68	3.00e-32	130.00
IUUC-Spo-108282	Schizosaccharomyces pombe	44.44	5.00e-33	133.00
IUUC-Smo-109561	Selaginella moellendorffii	44.34	3.00e-87	314.00
IUUC-Sit-110577	Setaria italica	58.39	2.00e-126	445.00
IUUC-Stu-112752	Solanum tuberosum	97.82	0.00e+00	846.00
IUUC-Sar-113701	Sorex araneus	40.41	4.00e-30	124.00
IUUC-Sbi-114308	Sorghum bicolor	58.62	2.00e-133	468.00
IUUC-Sre-115125	Sporisorium reilianum	42.48	2.00e-32	132.00
IUUC-Tgu-117039	Taeniopygia guttata	44.74	9.00e-23	98.20
IUUC-Tru-117939	Takifugu rubripes	42.00	1.00e-32	132.00
IUUC-Tsy-118852	Tarsius syrichta	38.60	1.00e-17	80.90
IUUC-Tni-120356	Tetraodon nigroviridis	41.10	6.00e-31	126.00
IUUC-Tca-121422	Theobroma cacao	70.45	0.00e+00	654.00
IUUC-Tre-122035	Trichoderma reesei	43.79	1.00e-32	132.00
IUUC-Tvi-122649	Trichoderma virens	43.79	1.00e-32	132.00
IUUC-Tae-124146	Triticum aestivum	50.73	7.00e-86	310.00
IUUC-Tme-127015	Tuber melanosporum	44.00	1.00e-32	132.00
IUUC-Tbe-128024	Tupaia belangeri	38.60	2.00e-17	80.50
IUUC-Ttr-128474	Tursiops truncatus	39.73	2.00e-30	124.00
IUUC-Uma-129655	Ustilago maydis	42.48	2.00e-32	132.00
IUUC-Vda-129970	Verticillium dahliae	39.22	5.00e-33	134.00
IUUC-Vpa-130564	Vicugna pacos	44.74	4.00e-23	99.40
IUUC-Vvi-131597	Vitis vinifera	65.87	2.00e-168	584.00
IUUC-Xtr-132201	Xenopus tropicalis	40.14	7.00e-31	126.00
IUUC-Xma-133679	Xiphophorus maculatus	41.33	3.00e-32	130.00
IUUC-Yli-134489	Yarrowia lipolytica	45.10	1.00e-32	132.00
IUUC-Zma-135058	Zea mays	56.04	4.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence