iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028095

Ensembl Protein ID

ENSDARP00000133720.1

UniProt Accession

Q5RKN6; Q5RKN6_DANRE

Genbank Protein ID

AAH85549.1; AAI65040.1

Protein Name

Growth factor receptor-bound protein 2a; Zgc:103549; Zgc:103549 protein

Genbank Nucleotide ID

CR387927; BC165040

Gene Name

grb2a; zgc:103549

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000105276.1	ENSDART00000164114.1	ENSDARP00000133720.1
ENSDARG00000105276.1	ENSDART00000164287.1	ENSDARP00000139535.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-36	125.3	158	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
             +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 158  STYVQALFDFDPQEDGELGFRRGDFIQVL--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 214
           679**************************..9*********..8**************997 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGEILKVLNE ECDQNWYKAE LNGKEGFIPK NYIEMKPHPW 60
FYGKIPRAKA EEMLNKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGCATT ATTCTCATGG ACAACTGGAT CCACCAATCT CTCCTGTTTT ATGCCAATCT 60
GTACTAATGT CTTCACTGCG AGACTACAAG GCTTTGATAG CAGGACACGC GCGTTTAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

dre:493609

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007965	Ashbya gossypii	35.96	1.00e-13	70.10
IUUC-Ame-010929	Astyanax mexicanus	96.31	1.00e-126	444.00
IUUC-Cel-018665	Caenorhabditis elegans	58.06	3.00e-71	261.00
IUUC-Csv-026210	Ciona savignyi	61.61	2.00e-72	265.00
IUUC-Lch-050230	Latimeria chalumnae	92.54	2.00e-71	262.00
IUUC-Ont-072253	Oreochromis niloticus	92.63	5.00e-121	426.00
IUUC-Pma-094650	Petromyzon marinus	83.41	4.00e-110	390.00
IUUC-Sce-106302	Saccharomyces cerevisiae	55.56	2.00e-16	79.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence