iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000015133.4	ENSCAFT00000024051.4	ENSCAFP00000022329.3
ENSCAFG00000015133.4	ENSCAFT00000049516.1	ENSCAFP00000037363.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-127	425.4	418	753

Active Site

Position(s)	Description	Evidence
722	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 418  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 505
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 506  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 590
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++idv+d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 591  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDVSDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 678
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 679  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 753
           ******************************99999**************************************76 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

PNWRRKYFLV TCQFSVLCAK NLAKKDFFRL PDPFAKIVVD GSGQCHSTDT VKNTLDPKWN 60
QHYDLYVGKT DSITISVWNH KKIHKKQGAG FLGCVRLLSN AISRLKDTGY QRLDLCKLNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAATTGGA GGAGAAAATA CTTTCTAGTT ACGTGTCAGG TTTTTTAGTT TAATGTAGCA 60
CTAAACTTGA AAGCCGATCA TTGGCAAAGA TAATTTCTAG AATATTTTTT TCTATTGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	90.28	0.00e+00	1415.00
IUUC-Apl-004155	Anas platyrhynchos	93.98	0.00e+00	1446.00
IUUC-Aca-005238	Anolis carolinensis	91.18	0.00e+00	1407.00
IUUC-Ame-010901	Astyanax mexicanus	86.09	0.00e+00	1341.00
IUUC-Bta-013221	Bos taurus	89.27	0.00e+00	1339.00
IUUC-Cja-018985	Callithrix jacchus	96.68	0.00e+00	1517.00
IUUC-Cpo-022531	Cavia porcellus	96.02	0.00e+00	1508.00
IUUC-Csa-024145	Chlorocebus sabaeus	93.63	0.00e+00	1456.00
IUUC-Cho-024963	Choloepus hoffmanni	79.71	0.00e+00	962.00
IUUC-Cin-025126	Ciona intestinalis	61.17	0.00e+00	909.00
IUUC-Csv-026339	Ciona savignyi	60.67	0.00e+00	923.00
IUUC-Dre-028341	Danio rerio	86.64	0.00e+00	1353.00
IUUC-Dno-029705	Dasypus novemcinctus	97.56	0.00e+00	1478.00
IUUC-Dme-031740	Drosophila melanogaster	70.85	9.00e-175	607.00
IUUC-Ete-032715	Echinops telfairi	67.62	0.00e+00	1033.00
IUUC-Eca-034125	Equus caballus	97.83	0.00e+00	1503.00
IUUC-Eeu-034945	Erinaceus europaeus	69.42	0.00e+00	1016.00
IUUC-Fca-035905	Felis catus	95.95	0.00e+00	1451.00
IUUC-Fal-037336	Ficedula albicollis	92.52	0.00e+00	1405.00
IUUC-Gmo-039486	Gadus morhua	76.53	0.00e+00	855.00
IUUC-Gga-040218	Gallus gallus	93.25	0.00e+00	1451.00
IUUC-Gac-041707	Gasterosteus aculeatus	80.05	0.00e+00	1239.00
IUUC-Ggo-045408	Gorilla gorilla	91.90	0.00e+00	1399.00
IUUC-Hsa-045878	Homo sapiens	96.29	0.00e+00	1511.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	97.29	0.00e+00	1493.00
IUUC-Lch-050026	Latimeria chalumnae	70.74	0.00e+00	1108.00
IUUC-Loc-052628	Lepisosteus oculatus	81.50	0.00e+00	1328.00
IUUC-Laf-053644	Loxodonta africana	89.99	0.00e+00	1385.00
IUUC-Mcc-055479	Macaca mulatta	86.07	0.00e+00	1307.00
IUUC-Meu-056436	Macropus eugenii	56.56	0.00e+00	818.00
IUUC-Mga-059723	Meleagris gallopavo	89.56	0.00e+00	1386.00
IUUC-Mmr-060806	Microcebus murinus	71.80	0.00e+00	1115.00
IUUC-Mdo-063005	Monodelphis domestica	92.97	0.00e+00	1450.00
IUUC-Mmu-063634	Mus musculus	93.37	0.00e+00	1432.00
IUUC-Mpu-065898	Mustela putorius furo	95.05	0.00e+00	1454.00
IUUC-Mlu-067584	Myotis lucifugus	97.05	0.00e+00	1504.00
IUUC-Nle-069033	Nomascus leucogenys	97.83	0.00e+00	1504.00
IUUC-Opr-070591	Ochotona princeps	67.92	0.00e+00	1030.00
IUUC-Ont-072265	Oreochromis niloticus	82.59	0.00e+00	1286.00
IUUC-Oan-073621	Ornithorhynchus anatinus	88.32	0.00e+00	1415.00
IUUC-Ocu-073960	Oryctolagus cuniculus	96.76	0.00e+00	1477.00
IUUC-Ola-086597	Oryzias latipes	74.37	0.00e+00	1139.00
IUUC-Oga-088579	Otolemur garnettii	96.55	0.00e+00	1514.00
IUUC-Oar-090396	Ovis aries	94.80	0.00e+00	1401.00
IUUC-Ptr-091624	Pan troglodytes	96.29	0.00e+00	1511.00
IUUC-Pan-092479	Papio anubis	97.71	0.00e+00	1509.00
IUUC-Psi-093298	Pelodiscus sinensis	71.94	0.00e+00	1115.00
IUUC-Pma-094354	Petromyzon marinus	64.83	0.00e+00	969.00
IUUC-Pfo-097203	Poecilia formosa	80.21	0.00e+00	1253.00
IUUC-Pab-097540	Pongo abelii	95.98	0.00e+00	1440.00
IUUC-Pca-100379	Procavia capensis	73.16	0.00e+00	646.00
IUUC-Pva-102754	Pteropus vampyrus	70.60	0.00e+00	1080.00
IUUC-Rno-105396	Rattus norvegicus	93.50	0.00e+00	1434.00
IUUC-Sha-107216	Sarcophilus harrisii	93.87	0.00e+00	1464.00
IUUC-Sar-113122	Sorex araneus	61.92	0.00e+00	912.00
IUUC-Ssc-116413	Sus scrofa	92.84	0.00e+00	1412.00
IUUC-Tgu-116723	Taeniopygia guttata	93.41	0.00e+00	1414.00
IUUC-Tru-117843	Takifugu rubripes	78.39	0.00e+00	1236.00
IUUC-Tsy-119455	Tarsius syrichta	97.04	0.00e+00	1411.00
IUUC-Tni-120037	Tetraodon nigroviridis	80.66	0.00e+00	1208.00
IUUC-Tbe-127879	Tupaia belangeri	83.74	0.00e+00	1234.00
IUUC-Ttr-128423	Tursiops truncatus	96.61	0.00e+00	1429.00
IUUC-Vpa-130591	Vicugna pacos	65.97	0.00e+00	994.00
IUUC-Xtr-132237	Xenopus tropicalis	87.27	0.00e+00	1363.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence