iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000019475.3	ENSXETT00000061037.1	ENSXETP00000063625.1
ENSXETG00000019475.3	ENSXETT00000042199.3	ENSXETP00000042199.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-135	452.3	562	894

Active Site

Position(s)	Description	Evidence
863	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++   gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hl++F+f+Gr++++al++g+++d+
   Q: 562  AQDLRRRLWIIIPGEEGLDYGGVAREWFFLLSHEVMNPMYCLFEYAGKDNYCLQINPASYI-NPDHLRYFRFIGRFIAMALFHGKFIDT 649
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle+vdpe+y+sl +ik+n   +iee+gl++ fsv++eilge+k+++Lkp+G+ni+Vt+eNkeeY++lv+e
   Q: 650  GFSLPFYKRILNKPVGLKDLESVDPEFYNSLIWIKDN---NIEECGLEMFFSVDKEILGEVKSHDLKPDGSNIQVTEENKEEYIRLVAE 735
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i+wFw++++e+++e+r ++LqFv
   Q: 736  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRNTIYRH-YTRTSKQIIWFWQFVKEIDNEKRMRLLQFV 823
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 824  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 894
           *********************************************************************96 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MDGSGSRPGA VNGFTMKSQL QVIVISAKLK DNRKNWFGPS PYVELSVDGQ SKKTETKNKT 60
HSPKWKQPLT VIVTPFSVLN FRVWSHQTLK SDALIGSASL NLHETLLSNN MKLEEVIVTM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGAGGAGT GAGAGTGGTT TTGGGGGGGT GACAGTTTGT TCCTGTCCCC GGCTGTGCTG 60
TGTCAGGCTC ATCCCTGGCT CGGTAAGTAG CGCTAATGGC TGTTTGCACT CAAGTTTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	76.69	0.00e+00	1301.00
IUUC-Apl-003752	Anas platyrhynchos	90.95	0.00e+00	1177.00
IUUC-Aca-005338	Anolis carolinensis	74.89	0.00e+00	1350.00
IUUC-Ame-010601	Astyanax mexicanus	87.18	0.00e+00	1106.00
IUUC-Bta-012782	Bos taurus	93.02	0.00e+00	1150.00
IUUC-Cja-018899	Callithrix jacchus	78.34	0.00e+00	1367.00
IUUC-Cfa-020648	Canis familiaris	76.62	0.00e+00	1302.00
IUUC-Cpo-022073	Cavia porcellus	90.47	0.00e+00	1162.00
IUUC-Csa-023252	Chlorocebus sabaeus	73.17	0.00e+00	1266.00
IUUC-Cho-024695	Choloepus hoffmanni	74.25	0.00e+00	1323.00
IUUC-Dre-028451	Danio rerio	87.46	0.00e+00	1108.00
IUUC-Dno-029884	Dasypus novemcinctus	75.36	0.00e+00	1349.00
IUUC-Eca-033793	Equus caballus	76.13	0.00e+00	1345.00
IUUC-Fca-035605	Felis catus	77.55	0.00e+00	1342.00
IUUC-Fal-037126	Ficedula albicollis	72.61	0.00e+00	1309.00
IUUC-Gmo-038596	Gadus morhua	79.90	0.00e+00	998.00
IUUC-Gga-040832	Gallus gallus	91.79	0.00e+00	1186.00
IUUC-Gac-041658	Gasterosteus aculeatus	84.12	0.00e+00	1122.00
IUUC-Ggo-044535	Gorilla gorilla	73.48	0.00e+00	1306.00
IUUC-Hsa-046564	Homo sapiens	77.04	0.00e+00	1373.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	89.97	0.00e+00	1155.00
IUUC-Lch-050454	Latimeria chalumnae	91.81	0.00e+00	1166.00
IUUC-Loc-052647	Lepisosteus oculatus	73.01	0.00e+00	1330.00
IUUC-Laf-054383	Loxodonta africana	90.13	0.00e+00	1159.00
IUUC-Mcc-055532	Macaca mulatta	72.73	0.00e+00	1256.00
IUUC-Mga-059661	Meleagris gallopavo	91.79	0.00e+00	1186.00
IUUC-Mmr-061135	Microcebus murinus	76.52	0.00e+00	1380.00
IUUC-Mdo-062505	Monodelphis domestica	77.27	0.00e+00	1375.00
IUUC-Mmu-063375	Mus musculus	90.47	0.00e+00	1163.00
IUUC-Mpu-066203	Mustela putorius furo	77.78	0.00e+00	1335.00
IUUC-Mlu-067837	Myotis lucifugus	71.90	0.00e+00	1297.00
IUUC-Nle-069244	Nomascus leucogenys	89.80	0.00e+00	1152.00
IUUC-Opr-070585	Ochotona princeps	89.80	0.00e+00	1150.00
IUUC-Ont-071822	Oreochromis niloticus	71.98	0.00e+00	1322.00
IUUC-Ocu-074298	Oryctolagus cuniculus	74.12	0.00e+00	1281.00
IUUC-Ola-086526	Oryzias latipes	86.67	0.00e+00	1114.00
IUUC-Oga-088167	Otolemur garnettii	70.85	0.00e+00	1204.00
IUUC-Oar-090316	Ovis aries	71.70	0.00e+00	811.00
IUUC-Ptr-090819	Pan troglodytes	75.91	0.00e+00	1330.00
IUUC-Pan-092454	Papio anubis	72.73	0.00e+00	1254.00
IUUC-Psi-093319	Pelodiscus sinensis	74.56	0.00e+00	1315.00
IUUC-Pfo-097346	Poecilia formosa	83.09	0.00e+00	1102.00
IUUC-Pab-097580	Pongo abelii	70.86	0.00e+00	1227.00
IUUC-Pca-100923	Procavia capensis	79.84	0.00e+00	1028.00
IUUC-Pva-103209	Pteropus vampyrus	73.00	0.00e+00	1256.00
IUUC-Rno-104924	Rattus norvegicus	71.98	0.00e+00	1261.00
IUUC-Sha-107175	Sarcophilus harrisii	73.78	0.00e+00	1291.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	47.01	4.00e-159	555.00
IUUC-Spo-108171	Schizosaccharomyces pombe	51.24	4.00e-163	568.00
IUUC-Sar-113761	Sorex araneus	92.67	0.00e+00	1143.00
IUUC-Sre-114929	Sporisorium reilianum	46.51	2.00e-153	536.00
IUUC-Tgu-116632	Taeniopygia guttata	72.58	0.00e+00	1253.00
IUUC-Tru-118442	Takifugu rubripes	89.43	0.00e+00	1125.00
IUUC-Tsy-119198	Tarsius syrichta	70.46	0.00e+00	1226.00
IUUC-Tni-120168	Tetraodon nigroviridis	85.99	0.00e+00	1057.00
IUUC-Tbe-127756	Tupaia belangeri	82.18	0.00e+00	825.00
IUUC-Ttr-128504	Tursiops truncatus	64.47	0.00e+00	867.00
IUUC-Vpa-130103	Vicugna pacos	66.56	0.00e+00	1134.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence