iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023083

Ensembl Protein ID

ENSCSAP00000002864.1

UniProt Accession

A0A0D9R2M5; A0A0D9R2M5_CHLSB

Genbank Protein ID

ENSCSAP00000002864

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AQIB01133841

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000006581.1	ENSCSAT00000004619.1	ENSCSAP00000002864.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.50e-29	101.9	1087	1138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
           +C+vC +++++e+ +++C++C++w+H+ C +l+ eee++n  +  + C+ Cr
   Q: 1087 SCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADigFDCSMCR 1138
           6********************************999999998899******8 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MSSEEDKSVE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 60
TAVEDEDSMD GLETTETETI VETAEIKEQS AEEDAEAEAD NSKQLIPALQ RSVSEESANS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTGCTGCT GCTCCCGGGG CTGCGGGAAA TGCGAGAGGC TGAGCCGGGG AGGAGGAACC 60
CGAGCAGCAG CGGCGGCGGC GGCGGCCGCG GCGGCGGGAG GAGCCCCCCA GGAGGAGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR000637--HMGI/Y_DNA-bd_CS
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS00354--HMGI_Y
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

csab:103227268

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	86.44	0.00e+00	5514.00
IUUC-Apl-003311	Anas platyrhynchos	69.39	0.00e+00	4124.00
IUUC-Aca-004705	Anolis carolinensis	63.39	0.00e+00	3812.00
IUUC-Bta-012322	Bos taurus	81.54	0.00e+00	5056.00
IUUC-Cel-018354	Caenorhabditis elegans	35.38	1.00e-64	243.00
IUUC-Cja-019983	Callithrix jacchus	94.64	0.00e+00	6271.00
IUUC-Cfa-020903	Canis familiaris	85.67	0.00e+00	5583.00
IUUC-Cpo-021732	Cavia porcellus	81.00	0.00e+00	5203.00
IUUC-Cho-024469	Choloepus hoffmanni	83.97	0.00e+00	2356.00
IUUC-Dre-028110	Danio rerio	46.62	0.00e+00	1961.00
IUUC-Dor-030569	Dipodomys ordii	78.88	0.00e+00	2949.00
IUUC-Dme-031590	Drosophila melanogaster	33.40	5.00e-70	259.00
IUUC-Eca-033945	Equus caballus	87.85	0.00e+00	5281.00
IUUC-Fca-035922	Felis catus	83.66	0.00e+00	5166.00
IUUC-Gac-041896	Gasterosteus aculeatus	45.82	0.00e+00	1860.00
IUUC-Ggo-044812	Gorilla gorilla	93.42	0.00e+00	6116.00
IUUC-Hsa-046595	Homo sapiens	96.77	0.00e+00	6448.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	85.10	0.00e+00	5322.00
IUUC-Lch-050086	Latimeria chalumnae	57.45	0.00e+00	2692.00
IUUC-Loc-052891	Lepisosteus oculatus	57.78	0.00e+00	3765.00
IUUC-Laf-054348	Loxodonta africana	84.23	0.00e+00	3151.00
IUUC-Mcc-054868	Macaca mulatta	99.19	0.00e+00	6507.00
IUUC-Meu-056322	Macropus eugenii	67.80	0.00e+00	1207.00
IUUC-Mga-059541	Meleagris gallopavo	69.13	0.00e+00	4223.00
IUUC-Mmr-061092	Microcebus murinus	91.11	0.00e+00	7909.00
IUUC-Mdo-062610	Monodelphis domestica	77.10	0.00e+00	2105.00
IUUC-Mmu-063666	Mus musculus	82.57	0.00e+00	5242.00
IUUC-Mpu-066366	Mustela putorius furo	82.67	0.00e+00	4952.00
IUUC-Mlu-068201	Myotis lucifugus	82.70	0.00e+00	4209.00
IUUC-Nle-069232	Nomascus leucogenys	97.07	0.00e+00	8385.00
IUUC-Opr-070625	Ochotona princeps	76.46	0.00e+00	1312.00
IUUC-Ont-072401	Oreochromis niloticus	53.26	0.00e+00	1201.00
IUUC-Oan-072945	Ornithorhynchus anatinus	76.45	0.00e+00	6205.00
IUUC-Ocu-074920	Oryctolagus cuniculus	87.44	0.00e+00	7462.00
IUUC-Ola-086436	Oryzias latipes	44.59	0.00e+00	1838.00
IUUC-Oga-088637	Otolemur garnettii	86.22	0.00e+00	4571.00
IUUC-Oar-089363	Ovis aries	79.83	0.00e+00	4942.00
IUUC-Ptr-091527	Pan troglodytes	96.64	0.00e+00	6434.00
IUUC-Pan-092102	Papio anubis	95.67	0.00e+00	6190.00
IUUC-Pma-094252	Petromyzon marinus	39.45	0.00e+00	675.00
IUUC-Pfo-096288	Poecilia formosa	46.94	0.00e+00	1458.00
IUUC-Pab-098241	Pongo abelii	97.05	0.00e+00	3543.00
IUUC-Pca-100103	Procavia capensis	81.17	0.00e+00	1584.00
IUUC-Pva-102238	Pteropus vampyrus	78.51	0.00e+00	2638.00
IUUC-Rno-105395	Rattus norvegicus	75.47	0.00e+00	1092.00
IUUC-Sha-106550	Sarcophilus harrisii	77.17	0.00e+00	6340.00
IUUC-Sar-113183	Sorex araneus	66.77	0.00e+00	695.00
IUUC-Tgu-116677	Taeniopygia guttata	68.07	0.00e+00	3790.00
IUUC-Tru-118037	Takifugu rubripes	60.97	0.00e+00	1180.00
IUUC-Tsy-118932	Tarsius syrichta	89.48	0.00e+00	3673.00
IUUC-Tni-119970	Tetraodon nigroviridis	46.46	0.00e+00	1811.00
IUUC-Ttr-129051	Tursiops truncatus	84.20	0.00e+00	5210.00
IUUC-Vpa-130236	Vicugna pacos	83.32	0.00e+00	1985.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence