iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035682

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02031010

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000029350.1	ENSFCAT00000027126.1	ENSFCAP00000021390.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-101	338.9	725	1048

Active Site

Position(s)	Description	Evidence
1017	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 725  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 806
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e+ p++ +s+++++++ e+d+ee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 807  HFPLALYKKLLKKKPSLDDLKELVPDVGRSMQQLLDYPEDDVEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 892
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 893  VDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 979
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 980  LLFLTGSDRIPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
           *******************...7777758889**************************************86 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCCCGCG AGCTACCTTC CCCCTCTCCC TTCTCCTCCC CAGTCTCTTC CCCAACTCTC 60
CCCACCCCTC GCGCTCTCCG CCCCGCTTGC CTCCTGTCCT TCCCCGCCCG CTCCATCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	98.86	0.00e+00	2012.00
IUUC-Apl-003295	Anas platyrhynchos	87.90	0.00e+00	1858.00
IUUC-Aca-004336	Anolis carolinensis	86.79	0.00e+00	1833.00
IUUC-Ame-010768	Astyanax mexicanus	73.71	0.00e+00	1580.00
IUUC-Bta-013279	Bos taurus	98.20	0.00e+00	2003.00
IUUC-Cel-018150	Caenorhabditis elegans	35.05	3.00e-150	526.00
IUUC-Cja-019023	Callithrix jacchus	97.54	0.00e+00	1988.00
IUUC-Cfa-021074	Canis familiaris	99.05	0.00e+00	2018.00
IUUC-Cpo-021461	Cavia porcellus	95.37	0.00e+00	1938.00
IUUC-Csa-024261	Chlorocebus sabaeus	97.92	0.00e+00	2000.00
IUUC-Cho-024513	Choloepus hoffmanni	78.74	0.00e+00	875.00
IUUC-Cin-025232	Ciona intestinalis	42.95	0.00e+00	819.00
IUUC-Dre-028829	Danio rerio	75.29	0.00e+00	1570.00
IUUC-Dno-029445	Dasypus novemcinctus	94.59	0.00e+00	1612.00
IUUC-Dor-030158	Dipodomys ordii	95.16	0.00e+00	855.00
IUUC-Dme-032103	Drosophila melanogaster	45.22	0.00e+00	894.00
IUUC-Ete-033072	Echinops telfairi	87.80	0.00e+00	1741.00
IUUC-Eca-033317	Equus caballus	96.59	0.00e+00	1962.00
IUUC-Eeu-035098	Erinaceus europaeus	48.24	0.00e+00	692.00
IUUC-Fal-036969	Ficedula albicollis	86.38	0.00e+00	1829.00
IUUC-Gmo-038671	Gadus morhua	74.13	0.00e+00	1575.00
IUUC-Gga-041174	Gallus gallus	87.51	0.00e+00	1856.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.77	0.00e+00	1511.00
IUUC-Gma-043616	Glycine max	36.99	5.00e-52	198.00
IUUC-Ggo-044589	Gorilla gorilla	97.54	0.00e+00	2024.00
IUUC-Hsa-046772	Homo sapiens	97.54	0.00e+00	2021.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	56.40	0.00e+00	1113.00
IUUC-Lch-050147	Latimeria chalumnae	81.06	0.00e+00	1438.00
IUUC-Loc-052684	Lepisosteus oculatus	80.97	0.00e+00	1703.00
IUUC-Laf-053844	Loxodonta africana	97.07	0.00e+00	1985.00
IUUC-Mcc-055531	Macaca mulatta	95.65	0.00e+00	1985.00
IUUC-Mga-060151	Meleagris gallopavo	86.66	0.00e+00	1537.00
IUUC-Mmr-060954	Microcebus murinus	97.54	0.00e+00	1989.00
IUUC-Mdo-062246	Monodelphis domestica	93.53	0.00e+00	1792.00
IUUC-Mmu-063369	Mus musculus	97.24	0.00e+00	2000.00
IUUC-Mpu-065936	Mustela putorius furo	98.17	0.00e+00	1848.00
IUUC-Mlu-067326	Myotis lucifugus	97.35	0.00e+00	1953.00
IUUC-Nle-069453	Nomascus leucogenys	98.67	0.00e+00	2005.00
IUUC-Opr-070891	Ochotona princeps	48.86	0.00e+00	905.00
IUUC-Ont-071720	Oreochromis niloticus	75.38	0.00e+00	1579.00
IUUC-Oan-073464	Ornithorhynchus anatinus	92.36	0.00e+00	1781.00
IUUC-Ocu-074207	Oryctolagus cuniculus	95.26	0.00e+00	1833.00
IUUC-Ola-086762	Oryzias latipes	74.41	0.00e+00	1533.00
IUUC-Oga-088435	Otolemur garnettii	97.73	0.00e+00	1992.00
IUUC-Oar-089233	Ovis aries	98.20	0.00e+00	2003.00
IUUC-Ptr-091368	Pan troglodytes	97.73	0.00e+00	2025.00
IUUC-Pan-092300	Papio anubis	97.92	0.00e+00	2000.00
IUUC-Psi-093406	Pelodiscus sinensis	89.12	0.00e+00	1878.00
IUUC-Pma-094113	Petromyzon marinus	71.65	0.00e+00	1132.00
IUUC-Ppa-095354	Physcomitrella patens	32.69	3.00e-148	519.00
IUUC-Pfo-097021	Poecilia formosa	73.78	0.00e+00	1590.00
IUUC-Pab-098327	Pongo abelii	97.92	0.00e+00	2028.00
IUUC-Pca-101075	Procavia capensis	96.27	0.00e+00	816.00
IUUC-Pva-102909	Pteropus vampyrus	86.66	0.00e+00	1689.00
IUUC-Rno-105457	Rattus norvegicus	96.69	0.00e+00	1991.00
IUUC-Sha-106632	Sarcophilus harrisii	94.76	0.00e+00	1964.00
IUUC-Sar-113679	Sorex araneus	89.90	0.00e+00	1161.00
IUUC-Ssc-115473	Sus scrofa	56.36	0.00e+00	1117.00
IUUC-Tgu-116849	Taeniopygia guttata	82.69	0.00e+00	1726.00
IUUC-Tru-118206	Takifugu rubripes	73.03	0.00e+00	1478.00
IUUC-Tsy-119521	Tarsius syrichta	83.07	0.00e+00	1591.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.60	0.00e+00	1464.00
IUUC-Tbe-127941	Tupaia belangeri	81.85	0.00e+00	1381.00
IUUC-Ttr-128926	Tursiops truncatus	98.08	0.00e+00	1174.00
IUUC-Vpa-130448	Vicugna pacos	97.82	0.00e+00	1992.00
IUUC-Xtr-132719	Xenopus tropicalis	71.24	0.00e+00	1396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence