iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055280

Ensembl Protein ID

ENSMMUP00000042452.1

UniProt Accession

H9FQ57; H9FQ57_MACMU

Genbank Protein ID

AFE76763.1; AFE76764.1; AFE76765.1; AFE76766.1; AFE76767.1; AFE76768.1; AFE76769.1; AFE76770.1; AFE76771.1; AFH31168.1; AFH31169.1; AFH31170.1; AFH31171.1; AFI36307.1

Protein Name

Adapter molecule crk isoform a

Genbank Nucleotide ID

JSUE03015715; JU333009; JU333010; JU333011; JU333012; JU333013; JU333014; JU333015; JU333016; JU474364; JU474365; JU474366; JU474367; JV046236

Gene Name

CRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000040390.1	ENSMMUT00000058676.1	ENSMMUP00000042452.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.10e-18	66.6	134	189

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            e+v++l+d++++++++L +kkGd++++   ++ +e W+++ ++ egkrG++P  +vek
   Q: 134  AEYVRALFDFNGNDEEDLPFKKGDILRI--RDKPEEQWWNA-EDSEGKRGMIPVPYVEK 189
           689*************************..6999******9.5**************98 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGCGGC GGCACCCCAG CGTTTAGGCG CGGAGGCAGC CATGGCGGGC AACTTCGACT 60
CGGAGGAGCG GAGTAGCTGG TACTGGGGGC GGTTGAGTCG GCAGGAGGCG GTGGCGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0070062--C:extracellular exosome
GO:0048013--P:ephrin receptor signaling pathway
GO:0009967--P:positive regulation of signal transduction
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0043087--P:regulation of GTPase activity

KEGG

mcc:701185

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001192	Ailuropoda melanoleuca	99.67	1.00e-160	558.00
IUUC-Apl-003225	Anas platyrhynchos	92.00	9.00e-123	432.00
IUUC-Aca-004818	Anolis carolinensis	78.35	4.00e-93	333.00
IUUC-Ame-011721	Astyanax mexicanus	68.35	1.00e-118	419.00
IUUC-Bta-012320	Bos taurus	100.00	8.00e-164	569.00
IUUC-Cel-018307	Caenorhabditis elegans	30.33	2.00e-26	112.00
IUUC-Cja-019935	Callithrix jacchus	96.38	5.00e-168	583.00
IUUC-Cfa-021221	Canis familiaris	99.67	1.00e-163	569.00
IUUC-Cpo-021592	Cavia porcellus	86.82	3.00e-138	484.00
IUUC-Csa-024128	Chlorocebus sabaeus	100.00	7.00e-101	359.00
IUUC-Cho-024775	Choloepus hoffmanni	98.03	3.00e-162	563.00
IUUC-Cin-025128	Ciona intestinalis	46.01	5.00e-73	267.00
IUUC-Csv-026340	Ciona savignyi	45.43	2.00e-66	246.00
IUUC-Dre-027390	Danio rerio	69.25	5.00e-120	423.00
IUUC-Dno-029847	Dasypus novemcinctus	100.00	8.00e-164	569.00
IUUC-Dor-030360	Dipodomys ordii	89.80	1.00e-156	545.00
IUUC-Dme-031600	Drosophila melanogaster	45.24	4.00e-66	244.00
IUUC-Ete-032604	Echinops telfairi	96.86	2.00e-126	444.00
IUUC-Eca-033233	Equus caballus	98.36	4.00e-163	566.00
IUUC-Eeu-034642	Erinaceus europaeus	97.31	3.00e-128	450.00
IUUC-Fca-035955	Felis catus	99.56	2.00e-131	461.00
IUUC-Fal-037152	Ficedula albicollis	86.83	2.00e-141	494.00
IUUC-Gmo-038849	Gadus morhua	67.72	4.00e-118	417.00
IUUC-Gga-040861	Gallus gallus	83.93	2.00e-150	524.00
IUUC-Gac-041627	Gasterosteus aculeatus	66.67	1.00e-120	426.00
IUUC-Ggo-045475	Gorilla gorilla	100.00	8.00e-164	569.00
IUUC-Hsa-046008	Homo sapiens	100.00	8.00e-164	569.00
IUUC-Itr-048906	Ictidomys tridecemlineatus	99.62	2.00e-134	471.00
IUUC-Lch-050509	Latimeria chalumnae	81.29	3.00e-148	517.00
IUUC-Loc-052229	Lepisosteus oculatus	73.53	2.00e-108	385.00
IUUC-Laf-053896	Loxodonta africana	95.11	4.00e-167	580.00
IUUC-Meu-056783	Macropus eugenii	96.86	6.00e-127	446.00
IUUC-Mga-059345	Meleagris gallopavo	92.38	6.00e-124	436.00
IUUC-Mdo-062691	Monodelphis domestica	88.31	5.00e-154	536.00
IUUC-Mmu-063691	Mus musculus	99.67	2.00e-163	568.00
IUUC-Mpu-065737	Mustela putorius furo	99.67	8.00e-164	569.00
IUUC-Mlu-067005	Myotis lucifugus	96.71	4.00e-159	553.00
IUUC-Nle-070154	Nomascus leucogenys	99.56	3.00e-131	460.00
IUUC-Opr-071114	Ochotona princeps	98.36	5.00e-176	609.00
IUUC-Ont-071696	Oreochromis niloticus	69.75	1.00e-115	409.00
IUUC-Oan-072967	Ornithorhynchus anatinus	93.46	9.00e-133	465.00
IUUC-Ocu-074025	Oryctolagus cuniculus	99.01	2.00e-99	354.00
IUUC-Olo-080293	Oryza longistaminata	40.00	1.90e+00	26.20
IUUC-Ola-086748	Oryzias latipes	56.07	4.00e-90	324.00
IUUC-Oga-088266	Otolemur garnettii	98.68	5.00e-163	566.00
IUUC-Oar-089221	Ovis aries	98.36	4.00e-159	553.00
IUUC-Ptr-091463	Pan troglodytes	95.39	1.00e-151	528.00
IUUC-Pan-092242	Papio anubis	99.67	8.00e-164	569.00
IUUC-Psi-093287	Pelodiscus sinensis	94.64	6.00e-127	446.00
IUUC-Pma-094340	Petromyzon marinus	58.68	2.00e-99	355.00
IUUC-Pfo-097378	Poecilia formosa	66.46	1.00e-110	392.00
IUUC-Pab-097823	Pongo abelii	100.00	7.00e-101	359.00
IUUC-Pca-101068	Procavia capensis	100.00	8.00e-164	569.00
IUUC-Pva-102346	Pteropus vampyrus	56.91	2.00e-92	331.00
IUUC-Rno-105288	Rattus norvegicus	99.67	2.00e-163	567.00
IUUC-Sha-106511	Sarcophilus harrisii	54.55	2.00e-53	201.00
IUUC-Sar-113453	Sorex araneus	84.54	7.00e-147	513.00
IUUC-Ssc-115339	Sus scrofa	57.05	5.00e-93	333.00
IUUC-Tgu-116926	Taeniopygia guttata	86.56	7.00e-150	523.00
IUUC-Tru-118656	Takifugu rubripes	66.87	2.00e-120	425.00
IUUC-Tsy-119327	Tarsius syrichta	55.27	1.00e-88	319.00
IUUC-Tni-120497	Tetraodon nigroviridis	68.81	6.00e-115	406.00
IUUC-Tbe-127436	Tupaia belangeri	95.07	7.00e-145	506.00
IUUC-Ttr-129109	Tursiops truncatus	100.00	1.00e-130	458.00
IUUC-Vpa-130527	Vicugna pacos	99.67	9.00e-162	562.00
IUUC-Xtr-131808	Xenopus tropicalis	84.59	3.00e-150	524.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence