iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050002

Ensembl Protein ID

ENSLACP00000006041.1

UniProt Accession

H3A8S0; H3A8S0_LATCH

Genbank Protein ID

ENSLACP00000006041

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AFYH01046023

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000005362.1	ENSLACT00000006093.1	ENSLACP00000006041.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-103	346.7	149	684

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 149  TGMKNIGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 232
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk.......eknkpkeeeeeedkselsde......................................... 129
           qqD+qEfl++l+dq++eelk+       e  ++ ee ++        +                                         
   Q: 233  QQDTQEFLRCLMDQIHEELKEplverdsECASDGEERRDG-------Drspsedeflscdsgassdrgegdarvgravaetelliqdec 314
           *******************886555544333444444444.......244445559********************************* PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 315  grgisekermkdrrfscsrhrsgseemdedadvdtsvapgiegppteppsqnytnspcrtsepdndafvrcpsrpaspvqqdalcklss 403
           ***************************************************************************************** PP
   S: 130  ........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......... 185
                                    ++k++ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+         
   Q: 404  spprsspirgapsyslkkahlllgGKKKQQPRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssihqntp 492
           ************************99*************************************************99888********* PP
   S: 186  ..........................................slqdcL...esftkeeelegenkyycekckkkqeaekklklkklPev 229
                                                      l++cL    sf+   +  g+n+y+ce+ckk+++ +k +k+ +lPev
   Q: 493  pktgscgdsyntqgwiafimdyirrsirvcrshkkkkteinqVLHKCLmpfYSFSHISKSAGDNMYSCERCKKLRNGVKYCKVLRLPEV 581
           ******************************************99999855577888888899*************************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVte 316
           L++hLkRf  ++e + + kin++v+fple L+l+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vte
   Q: 582  LCIHLKRF--RHEVMYSFKINSHVSFPLEgLELRPFLAKESPSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTE 666
           ********..9999*************************88887..9**************************78999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+e+ v++   ++aYvlfY++
   Q: 667  VHETVVQN---AEAYVLFYRK 684
           ********...********98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

RMVDSVEVCP HLDSIGEVTK EDLLLKSKGT CQSCGVGGPN LWACLQNGCP YVGCGESFAD 60
HSTLHAQAKK HNLTVNLTTF RVWCYSCEKE VFLEQRHAVQ PTVQQQSKDV QQDSVSPPSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGTCTCCT TACATTGCTT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGGGT 60
GGGGTGGGGG AACCAAAAAA AACCAAATGC ATTTAGCACC GAATGTGTGT ATCAATTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	73.19	0.00e+00	1308.00
IUUC-Apl-003351	Anas platyrhynchos	77.86	0.00e+00	1384.00
IUUC-Aca-005077	Anolis carolinensis	68.98	0.00e+00	962.00
IUUC-Ame-011777	Astyanax mexicanus	73.31	0.00e+00	1269.00
IUUC-Bta-013063	Bos taurus	75.08	0.00e+00	1314.00
IUUC-Cja-019868	Callithrix jacchus	76.30	0.00e+00	1355.00
IUUC-Cfa-020761	Canis familiaris	74.65	0.00e+00	1325.00
IUUC-Cpo-022267	Cavia porcellus	72.94	0.00e+00	1276.00
IUUC-Csa-024251	Chlorocebus sabaeus	76.92	0.00e+00	1370.00
IUUC-Cho-024483	Choloepus hoffmanni	84.06	3.00e-102	366.00
IUUC-Dre-028061	Danio rerio	71.63	0.00e+00	1125.00
IUUC-Dno-029423	Dasypus novemcinctus	76.19	0.00e+00	1333.00
IUUC-Dor-030877	Dipodomys ordii	72.52	0.00e+00	833.00
IUUC-Ete-032802	Echinops telfairi	69.49	2.00e-121	429.00
IUUC-Eca-034283	Equus caballus	73.81	0.00e+00	1304.00
IUUC-Eeu-034620	Erinaceus europaeus	71.97	0.00e+00	922.00
IUUC-Fca-036357	Felis catus	75.38	0.00e+00	1299.00
IUUC-Fal-037411	Ficedula albicollis	78.01	0.00e+00	1382.00
IUUC-Gga-041101	Gallus gallus	77.37	0.00e+00	1375.00
IUUC-Gac-041315	Gasterosteus aculeatus	71.77	0.00e+00	1255.00
IUUC-Ggo-045600	Gorilla gorilla	76.70	0.00e+00	1339.00
IUUC-Hsa-045825	Homo sapiens	76.71	0.00e+00	1344.00
IUUC-Loc-052574	Lepisosteus oculatus	76.41	0.00e+00	1340.00
IUUC-Laf-054428	Loxodonta africana	75.54	0.00e+00	1333.00
IUUC-Mcc-055736	Macaca mulatta	76.71	0.00e+00	1368.00
IUUC-Mga-059781	Meleagris gallopavo	77.38	0.00e+00	1375.00
IUUC-Mdo-063048	Monodelphis domestica	77.15	0.00e+00	1325.00
IUUC-Mmu-064079	Mus musculus	72.94	0.00e+00	1301.00
IUUC-Mpu-066616	Mustela putorius furo	74.57	0.00e+00	1342.00
IUUC-Mlu-067294	Myotis lucifugus	75.41	0.00e+00	1292.00
IUUC-Nle-070015	Nomascus leucogenys	76.60	0.00e+00	1327.00
IUUC-Opr-070328	Ochotona princeps	75.60	0.00e+00	1339.00
IUUC-Ont-071464	Oreochromis niloticus	72.51	0.00e+00	1239.00
IUUC-Ocu-074630	Oryctolagus cuniculus	73.43	0.00e+00	1272.00
IUUC-Ola-087240	Oryzias latipes	72.52	0.00e+00	1215.00
IUUC-Oga-088761	Otolemur garnettii	74.57	0.00e+00	1327.00
IUUC-Oar-089490	Ovis aries	72.74	0.00e+00	1221.00
IUUC-Ptr-091662	Pan troglodytes	76.92	0.00e+00	1345.00
IUUC-Pan-092199	Papio anubis	76.92	0.00e+00	1366.00
IUUC-Psi-093726	Pelodiscus sinensis	77.96	0.00e+00	1379.00
IUUC-Pma-094389	Petromyzon marinus	64.12	4.00e-102	363.00
IUUC-Pab-098632	Pongo abelii	76.49	0.00e+00	1335.00
IUUC-Rno-105215	Rattus norvegicus	72.91	0.00e+00	1299.00
IUUC-Sha-106601	Sarcophilus harrisii	74.97	0.00e+00	1315.00
IUUC-Ssc-115533	Sus scrofa	74.25	0.00e+00	1305.00
IUUC-Tgu-117364	Taeniopygia guttata	78.13	0.00e+00	1382.00
IUUC-Tru-117770	Takifugu rubripes	70.86	0.00e+00	1238.00
IUUC-Tni-120001	Tetraodon nigroviridis	69.96	0.00e+00	1201.00
IUUC-Ttr-128732	Tursiops truncatus	75.97	0.00e+00	1323.00
IUUC-Xtr-132157	Xenopus tropicalis	71.30	0.00e+00	1218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence