iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106773

Ensembl Protein ID

ENSSHAP00000017995.1

UniProt Accession

G3WRE0; G3WRE0_SARHA

Genbank Protein ID

ENSSHAP00000017995

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AEFK01193341

Gene Name

ING4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015278.1	ENSSHAT00000018144.1	ENSSHAP00000017995.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-09	38.5	251	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 251  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 298
           69*.*******99..********999***********...899996.******97 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MGGSARARNT LRAEFPPPPP FKGGRGLVSG ISSSPGRSSI TSGNGPEVAL FCFKMAAGMY 60
LEHYLDSIEN LPFELQRNFQ LMRDLDQRTE DLKAEIDKLA TEYMSSARSL NSEEKLALLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGACTGGGA AGCTGAGGCT GAGACGAGAC ACACGCGGAT TTGAACTCGT CCTCCCGCCT 60
CCAAGCCCGC TACTCTATGC GCAACACAGT ACCCGGCCGC CTTTGCGGCC TAGGCACGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	97.99	2.00e-126	444.00
IUUC-Apl-004097	Anas platyrhynchos	92.34	5.00e-118	416.00
IUUC-Aca-004593	Anolis carolinensis	95.58	7.00e-124	436.00
IUUC-Ame-011133	Astyanax mexicanus	80.88	8.00e-116	409.00
IUUC-Bta-012699	Bos taurus	96.79	5.00e-126	443.00
IUUC-Bdi-014504	Brachypodium distachyon	36.25	2.00e-39	155.00
IUUC-Cja-019988	Callithrix jacchus	98.39	2.00e-120	424.00
IUUC-Cfa-021282	Canis familiaris	98.39	2.00e-120	424.00
IUUC-Cpo-022011	Cavia porcellus	98.39	2.00e-130	457.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	31.23	9.00e-29	120.00
IUUC-Csa-023203	Chlorocebus sabaeus	98.39	2.00e-120	424.00
IUUC-Cin-025479	Ciona intestinalis	61.34	4.00e-79	286.00
IUUC-Csv-026288	Ciona savignyi	54.68	3.00e-75	274.00
IUUC-Dre-028264	Danio rerio	80.48	4.00e-114	403.00
IUUC-Dno-029766	Dasypus novemcinctus	95.56	6.00e-114	402.00
IUUC-Dor-031136	Dipodomys ordii	83.90	2.00e-98	351.00
IUUC-Dme-032200	Drosophila melanogaster	74.19	1.00e-40	159.00
IUUC-Eca-033565	Equus caballus	98.39	3.00e-130	457.00
IUUC-Eeu-034948	Erinaceus europaeus	78.95	1.00e-99	355.00
IUUC-Fca-036368	Felis catus	98.80	6.00e-121	426.00
IUUC-Fal-037120	Ficedula albicollis	91.94	7.00e-117	412.00
IUUC-Gmo-038982	Gadus morhua	80.40	3.00e-115	407.00
IUUC-Gga-040771	Gallus gallus	95.58	7.00e-124	436.00
IUUC-Gac-042184	Gasterosteus aculeatus	79.67	2.00e-111	394.00
IUUC-Gma-044339	Glycine max	29.76	4.00e-34	137.00
IUUC-Ggo-045559	Gorilla gorilla	98.39	2.00e-120	424.00
IUUC-Hsa-046852	Homo sapiens	98.39	2.00e-120	424.00
IUUC-Hvu-047046	Hordeum vulgare	35.71	4.00e-38	150.00
IUUC-Itr-047978	Ictidomys tridecemlineatus	97.99	5.00e-130	456.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	2.00e-16	79.30
IUUC-Lpe-050822	Leersia perrieri	34.26	6.00e-38	150.00
IUUC-Laf-054057	Loxodonta africana	98.80	6.00e-121	426.00
IUUC-Mcc-055212	Macaca mulatta	92.43	4.00e-115	407.00
IUUC-Meu-056511	Macropus eugenii	100.00	4.00e-123	433.00
IUUC-Mtr-058288	Medicago truncatula	32.22	8.00e-33	133.00
IUUC-Mga-059967	Meleagris gallopavo	93.12	1.00e-117	414.00
IUUC-Mmr-060843	Microcebus murinus	96.79	2.00e-126	444.00
IUUC-Mdo-062357	Monodelphis domestica	100.00	6.00e-132	462.00
IUUC-Mmu-064093	Mus musculus	98.39	2.00e-130	457.00
IUUC-Mac-064625	Musa acuminata	32.94	1.00e-35	142.00
IUUC-Mpu-066923	Mustela putorius furo	87.15	1.00e-97	348.00
IUUC-Mlu-067754	Myotis lucifugus	90.87	2.00e-118	418.00
IUUC-Nle-069062	Nomascus leucogenys	98.39	2.00e-120	424.00
IUUC-Opr-070207	Ochotona princeps	91.53	4.00e-111	393.00
IUUC-Ont-072446	Oreochromis niloticus	80.80	5.00e-114	403.00
IUUC-Ocu-074235	Oryctolagus cuniculus	98.39	2.00e-120	424.00
IUUC-Obr-076266	Oryza brachyantha	35.86	9.00e-37	146.00
IUUC-Ogl-077118	Oryza glaberrima	33.73	2.00e-36	145.00
IUUC-Ome-081291	Oryza meridionalis	33.73	5.00e-37	147.00
IUUC-Opu-084171	Oryza punctata	34.69	3.00e-36	145.00
IUUC-Osa-085563	Oryza sativa	33.73	5.00e-37	147.00
IUUC-Ola-086429	Oryzias latipes	76.00	6.00e-105	372.00
IUUC-Olu-087851	Ostreococcus lucimarinus	33.95	4.00e-20	90.90
IUUC-Oga-089123	Otolemur garnettii	98.80	6.00e-121	426.00
IUUC-Oar-089524	Ovis aries	96.79	5.00e-126	443.00
IUUC-Ptr-090908	Pan troglodytes	97.99	7.00e-120	422.00
IUUC-Pan-092837	Papio anubis	97.59	6.00e-126	442.00
IUUC-Psi-093828	Pelodiscus sinensis	95.28	3.00e-113	400.00
IUUC-Ppa-096009	Physcomitrella patens	34.77	1.00e-34	139.00
IUUC-Pfo-096617	Poecilia formosa	80.40	5.00e-114	402.00
IUUC-Pab-097978	Pongo abelii	97.88	1.00e-109	388.00
IUUC-Pop-099415	Populus trichocarpa	73.68	1.00e-26	112.00
IUUC-Pca-100475	Procavia capensis	66.67	4.00e-86	310.00
IUUC-Ppe-101441	Prunus persica	32.94	3.00e-37	148.00
IUUC-Pva-102325	Pteropus vampyrus	98.39	3.00e-130	457.00
IUUC-Rno-105178	Rattus norvegicus	96.79	8.00e-136	475.00
IUUC-Sit-109827	Setaria italica	34.26	2.00e-36	145.00
IUUC-Sbi-114826	Sorghum bicolor	35.46	2.00e-37	148.00
IUUC-Sre-115124	Sporisorium reilianum	58.21	1.00e-22	101.00
IUUC-Ssc-115797	Sus scrofa	91.87	7.00e-105	372.00
IUUC-Tgu-117270	Taeniopygia guttata	95.58	7.00e-124	436.00
IUUC-Tru-118253	Takifugu rubripes	79.68	3.00e-114	403.00
IUUC-Tae-123043	Triticum aestivum	34.75	2.00e-37	148.00
IUUC-Tbe-127558	Tupaia belangeri	97.99	2.00e-126	444.00
IUUC-Ttr-128300	Tursiops truncatus	99.09	4.00e-65	240.00
IUUC-Uma-129581	Ustilago maydis	57.63	1.00e-21	98.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence