iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107278

Ensembl Protein ID

ENSSHAP00000014900.1

UniProt Accession

G3WHJ5; G3WHJ5_SARHA

Genbank Protein ID

ENSSHAP00000014900

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AEFK01018517

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000012712.1	ENSSHAT00000015025.1	ENSSHAP00000014900.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.30e-15	57.5	1712	1752

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1712 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1752
           8*********....*******************....99996.******8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MDQTCELPRR NCLQPFSNRV DLDAPEEKDT PFGNGQSNIS EPLNGCAIQL SAAINSGTSK 60
ITYGQDPSSC YIPLRRLQDL ASMINVEYLN GSTDGSESLQ DPEKRDSRSG SPNVCTSLSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCAGA CCTGTGAACT GCCCAGAAGA AATTGTCTGC AGCCCTTTTC TAACAGAGTG 60
GATTTAGATG CCCCTGAAGA AAAGGACACC CCTTTCGGTA ATGGTCAATC CAATATTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001795	Ailuropoda melanoleuca	69.97	0.00e+00	3543.00
IUUC-Apl-003953	Anas platyrhynchos	59.35	0.00e+00	2318.00
IUUC-Aca-005339	Anolis carolinensis	50.68	0.00e+00	1753.00
IUUC-Bta-012966	Bos taurus	70.39	0.00e+00	3601.00
IUUC-Bra-017864	Brassica rapa	24.27	1.00e-15	79.70
IUUC-Cja-018780	Callithrix jacchus	71.15	0.00e+00	3403.00
IUUC-Cfa-020975	Canis familiaris	70.07	0.00e+00	3595.00
IUUC-Cpo-021331	Cavia porcellus	70.73	0.00e+00	2122.00
IUUC-Csa-024226	Chlorocebus sabaeus	69.54	0.00e+00	3118.00
IUUC-Cho-024464	Choloepus hoffmanni	58.63	0.00e+00	998.00
IUUC-Dre-027488	Danio rerio	61.24	0.00e+00	1262.00
IUUC-Dno-029230	Dasypus novemcinctus	68.96	0.00e+00	3440.00
IUUC-Dor-031016	Dipodomys ordii	70.43	0.00e+00	1187.00
IUUC-Dme-032193	Drosophila melanogaster	35.94	7.00e-122	432.00
IUUC-Eca-033591	Equus caballus	69.57	0.00e+00	3141.00
IUUC-Fca-035791	Felis catus	70.42	0.00e+00	3650.00
IUUC-Fal-037378	Ficedula albicollis	60.64	0.00e+00	2145.00
IUUC-Gmo-038919	Gadus morhua	71.89	0.00e+00	947.00
IUUC-Gga-040881	Gallus gallus	59.34	0.00e+00	2247.00
IUUC-Gac-041378	Gasterosteus aculeatus	78.51	0.00e+00	1074.00
IUUC-Hsa-046436	Homo sapiens	69.92	0.00e+00	3534.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	69.19	0.00e+00	3147.00
IUUC-Lch-049684	Latimeria chalumnae	47.36	0.00e+00	1668.00
IUUC-Lpe-051661	Leersia perrieri	28.72	6.00e-12	66.60
IUUC-Laf-054046	Loxodonta africana	69.82	0.00e+00	3110.00
IUUC-Mcc-055593	Macaca mulatta	69.59	0.00e+00	3511.00
IUUC-Mga-059756	Meleagris gallopavo	58.98	0.00e+00	2333.00
IUUC-Mmr-061182	Microcebus murinus	69.38	0.00e+00	3549.00
IUUC-Mdo-061984	Monodelphis domestica	90.77	0.00e+00	4137.00
IUUC-Mmu-063605	Mus musculus	66.24	0.00e+00	3315.00
IUUC-Mpu-066446	Mustela putorius furo	70.02	0.00e+00	3604.00
IUUC-Mlu-067261	Myotis lucifugus	69.82	0.00e+00	3532.00
IUUC-Nle-069818	Nomascus leucogenys	69.68	0.00e+00	3138.00
IUUC-Opr-070842	Ochotona princeps	69.90	0.00e+00	1930.00
IUUC-Ont-072448	Oreochromis niloticus	75.22	0.00e+00	1152.00
IUUC-Oan-073496	Ornithorhynchus anatinus	81.34	0.00e+00	1638.00
IUUC-Ocu-074918	Oryctolagus cuniculus	70.07	0.00e+00	3588.00
IUUC-Obr-076753	Oryza brachyantha	54.84	8.00e-08	53.50
IUUC-Ola-087518	Oryzias latipes	75.73	0.00e+00	1055.00
IUUC-Oga-088743	Otolemur garnettii	68.59	0.00e+00	3004.00
IUUC-Oar-090265	Ovis aries	70.31	0.00e+00	3596.00
IUUC-Ptr-090521	Pan troglodytes	69.97	0.00e+00	3542.00
IUUC-Psi-093245	Pelodiscus sinensis	60.53	0.00e+00	2052.00
IUUC-Pfo-096066	Poecilia formosa	62.63	0.00e+00	1223.00
IUUC-Pab-098644	Pongo abelii	69.59	0.00e+00	3124.00
IUUC-Pva-103094	Pteropus vampyrus	63.54	0.00e+00	1820.00
IUUC-Rno-105803	Rattus norvegicus	66.35	0.00e+00	2942.00
IUUC-Sar-113402	Sorex araneus	63.90	0.00e+00	2125.00
IUUC-Sbi-114400	Sorghum bicolor	37.50	3.00e-13	67.00
IUUC-Ssc-116193	Sus scrofa	69.59	0.00e+00	3109.00
IUUC-Tgu-116532	Taeniopygia guttata	90.30	0.00e+00	1262.00
IUUC-Tru-117988	Takifugu rubripes	77.78	0.00e+00	1199.00
IUUC-Tsy-118830	Tarsius syrichta	71.10	0.00e+00	2898.00
IUUC-Tca-121456	Theobroma cacao	31.28	3.00e-20	93.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence