iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028669

UUCD1 version

UUC-DaR-01083

Ensembl Protein ID

ENSDARP00000061000.3

UniProt Accession

O42248; GBLP_DANRE

Genbank Protein ID

AAB81617.1; AAQ98014.1; AAH49459.1

Protein Name

Guanine nucleotide-binding protein subunit beta-2-like 1; Receptor of activated protein kinase C

Genbank Nucleotide ID

AF025330; AY423038; BC049459

Gene Name

gnb2l1; rack1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000041619.4	ENSDART00000061001.4	ENSDARP00000061000.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-44	149.2	147	181
UBD/Beta-Prp	4.50e-55	187.9	10	263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf....sdtllvsGsdDgtikvWDlrt 32
           Ht++v+c++f    s++++vs+++D+ +kvW+l  
   Q: 147  HTEWVSCVRFspnsSNPIIVSCGWDKMVKVWNLAN 181
           ***********98544****************865 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkf.spdksllatgsrdgtikvwdvttgkl.....lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkc 86
           tlkgh   v + ++   ++ ++++++srd+ti+ w++t+  +      r l gh+ +v++v +s+dg++ ++gs D+t+++wdl tg++
   Q: 10   TLKGHSGWVTQ-IATtPQFPDMILSASRDKTIIMWKLTRDETnygipQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT 97
           55666655555.555489999******************999*********************************************** PP
   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllr 173
           ++ + gh+++vls++fs+++  +vsGs+d+ti++w++    ++   ++ h+++v+cv+++p++   ++vs++ D++v++W+l++ kl +
   Q: 98   TRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLGVCKYTIQDDSHTEWVSCVRFSPNSsnPIIVSCGWDKMVKVWNLANCKLKT 186
           ***********************************7765555544899*************998569***************7777776 PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
              g ht++ + ++++++g  ++sg++dg+  lwdl +g+ ++tl g  d+++ + fs  + + ++++  +si+iWdl+ 
   Q: 187  NHIG-HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DTINALCFS-PNRYWLCAATGPSIKIWDLEG 263
           6676.****************************************997.568889999.7788889999********986 PP

Organism

Danio rerio

Functional Description
(View)

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation.

Protein Sequence
(Fasta)

MTEQMTVRGT LKGHSGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 60
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSADNRQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCTACTTC CTTTTCCTCT TGCCACAGTG TGAGAGATAT AGGGAGGACT CGGCCCTCCG 60
ACAAAATCCA ACTCCATCCA CCTTCTTAGG TGCTTCTATC CTCGCCAAAA TGACCGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0689--Ribosomal protein
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001525--P:angiogenesis
GO:0060027--P:convergent extension involved in gastrulation
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:2000543--P:positive regulation of gastrulation
GO:0051302--P:regulation of cell division
GO:2000114--P:regulation of establishment of cell polarity
GO:0032880--P:regulation of protein localization

KEGG

dre:30722

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000395	Aegilops tauschii	64.08	1.00e-101	362.00
IUUC-Aml-001935	Ailuropoda melanoleuca	95.58	0.00e+00	636.00
IUUC-Atr-002694	Amborella trichopoda	69.01	1.00e-125	442.00
IUUC-Apl-003918	Anas platyrhynchos	95.73	7.00e-163	566.00
IUUC-Aca-004869	Anolis carolinensis	95.58	0.00e+00	636.00
IUUC-Aly-005671	Arabidopsis lyrata	65.12	5.00e-125	440.00
IUUC-Ath-007105	Arabidopsis thaliana	65.33	9.00e-125	439.00
IUUC-Ago-007720	Ashbya gossypii	55.59	2.00e-101	362.00
IUUC-Acl-008156	Aspergillus clavatus	71.47	1.00e-136	479.00
IUUC-Afl-008684	Aspergillus flavus	71.15	4.00e-136	477.00
IUUC-Afu-008867	Aspergillus fumigatus	72.76	2.00e-138	485.00
IUUC-Ani-009221	Aspergillus nidulans	72.12	2.00e-137	481.00
IUUC-Ang-009843	Aspergillus niger	71.15	1.00e-135	475.00
IUUC-Aor-010193	Aspergillus oryzae	71.15	4.00e-136	477.00
IUUC-Ate-010420	Aspergillus terreus	72.79	9.00e-125	439.00
IUUC-Ame-011199	Astyanax mexicanus	96.53	0.00e+00	642.00
IUUC-Bgr-012064	Blumeria graminis	70.83	2.00e-135	475.00
IUUC-Bta-013357	Bos taurus	95.58	0.00e+00	636.00
IUUC-Bci-013862	Botrytis cinerea	71.15	5.00e-137	480.00
IUUC-Bdi-014690	Brachypodium distachyon	61.77	4.00e-112	397.00
IUUC-Bol-016231	Brassica oleracea	66.25	7.00e-127	446.00
IUUC-Bra-016879	Brassica rapa	65.84	2.00e-125	441.00
IUUC-Cel-018335	Caenorhabditis elegans	69.69	9.00e-124	436.00
IUUC-Cja-019914	Callithrix jacchus	95.58	0.00e+00	636.00
IUUC-Cfa-020755	Canis familiaris	95.58	0.00e+00	636.00
IUUC-Cpo-022377	Cavia porcellus	95.58	0.00e+00	638.00
IUUC-Cre-022909	Chlamydomonas reinhardtii	74.92	3.00e-137	481.00
IUUC-Csa-023025	Chlorocebus sabaeus	95.58	0.00e+00	636.00
IUUC-Cin-025647	Ciona intestinalis	78.34	3.00e-148	518.00
IUUC-Csv-026027	Ciona savignyi	78.03	5.00e-146	510.00
IUUC-Cgl-026718	Colletotrichum gloeosporioides	74.56	2.00e-128	451.00
IUUC-Cne-026930	Cryptococcus neoformans	71.79	5.00e-137	480.00
IUUC-Cme-027251	Cyanidioschyzon merolae	64.42	8.00e-123	433.00
IUUC-Dno-029470	Dasypus novemcinctus	80.13	2.00e-144	504.00
IUUC-Dor-031098	Dipodomys ordii	85.49	9.00e-145	506.00
IUUC-Dse-031255	Dothistroma septosporum	73.08	8.00e-139	486.00
IUUC-Dme-032118	Drosophila melanogaster	77.14	6.00e-147	513.00
IUUC-Ete-033182	Echinops telfairi	80.27	4.00e-103	367.00
IUUC-Eca-033296	Equus caballus	94.00	1.00e-84	304.00
IUUC-Eeu-034771	Erinaceus europaeus	90.54	4.00e-172	597.00
IUUC-Fca-036315	Felis catus	95.58	0.00e+00	636.00
IUUC-Fal-036990	Ficedula albicollis	92.22	3.00e-100	358.00
IUUC-Fox-037702	Fusarium oxysporum	72.12	2.00e-138	485.00
IUUC-Fso-038384	Fusarium solani	72.76	9.00e-139	486.00
IUUC-Gmo-039630	Gadus morhua	94.81	2.00e-177	614.00
IUUC-Ggr-039985	Gaeumannomyces graminis	71.79	3.00e-138	484.00
IUUC-Gga-040540	Gallus gallus	95.58	0.00e+00	636.00
IUUC-Gac-041316	Gasterosteus aculeatus	92.60	1.00e-175	608.00
IUUC-Gma-042872	Glycine max	66.15	2.00e-125	441.00
IUUC-Ggo-045253	Gorilla gorilla	95.58	0.00e+00	636.00
IUUC-Hsa-046809	Homo sapiens	95.58	0.00e+00	636.00
IUUC-Hvu-047683	Hordeum vulgare	62.31	2.00e-113	402.00
IUUC-Itr-048025	Ictidomys tridecemlineatus	95.58	0.00e+00	636.00
IUUC-Kpa-049214	Komagataella pastoris	56.77	8.00e-99	353.00
IUUC-Lch-049634	Latimeria chalumnae	93.06	2.00e-179	621.00
IUUC-Lpe-050763	Leersia perrieri	61.77	8.00e-112	396.00
IUUC-Loc-052163	Lepisosteus oculatus	97.79	0.00e+00	644.00
IUUC-Lma-053113	Leptosphaeria maculans	73.08	3.00e-139	487.00
IUUC-Laf-054422	Loxodonta africana	95.58	0.00e+00	636.00
IUUC-Mcc-055348	Macaca mulatta	95.58	0.00e+00	636.00
IUUC-Meu-056543	Macropus eugenii	95.58	0.00e+00	637.00
IUUC-Mor-057107	Magnaporthe oryzae	71.79	9.00e-139	486.00
IUUC-Mpo-057487	Magnaporthe poae	72.12	9.00e-139	486.00
IUUC-Mtr-058808	Medicago truncatula	66.46	4.00e-126	444.00
IUUC-Mla-058909	Melampsora laricipopulina	73.16	4.00e-139	487.00
IUUC-Mga-059387	Meleagris gallopavo	95.58	0.00e+00	636.00
IUUC-Mvi-060392	Microbotryum violaceum	69.87	4.00e-135	473.00
IUUC-Mmr-061141	Microcebus murinus	85.12	2.00e-135	474.00
IUUC-Mdo-062932	Monodelphis domestica	95.58	0.00e+00	636.00
IUUC-Mmu-064132	Mus musculus	95.58	0.00e+00	636.00
IUUC-Mac-064447	Musa acuminata	61.42	1.00e-108	386.00
IUUC-Mpu-066721	Mustela putorius furo	94.64	1.00e-180	625.00
IUUC-Mlu-068221	Myotis lucifugus	94.95	5.00e-172	596.00
IUUC-Nfi-068344	Neosartorya fischeri	72.76	2.00e-138	485.00
IUUC-Ncr-068722	Neurospora crassa	71.15	1.00e-136	479.00
IUUC-Nle-069865	Nomascus leucogenys	95.58	0.00e+00	637.00
IUUC-Opr-071100	Ochotona princeps	80.44	6.00e-147	513.00
IUUC-Ont-072287	Oreochromis niloticus	95.90	0.00e+00	635.00
IUUC-Oan-072788	Ornithorhynchus anatinus	95.58	0.00e+00	636.00
IUUC-Ocu-073844	Oryctolagus cuniculus	93.06	3.00e-177	614.00
IUUC-Oba-075981	Oryza barthii	59.63	2.00e-101	362.00
IUUC-Obr-076099	Oryza brachyantha	60.55	3.00e-111	394.00
IUUC-Ogl-077804	Oryza glaberrima	61.77	3.00e-113	401.00
IUUC-Ogu-078035	Oryza glumaepatula	63.08	3.00e-113	401.00
IUUC-Oin-079327	Oryza indica	63.08	3.00e-113	401.00
IUUC-Olo-081084	Oryza longistaminata	63.08	3.00e-113	401.00
IUUC-Ome-081366	Oryza meridionalis	62.08	2.00e-113	402.00
IUUC-Oni-082682	Oryza nivara	62.08	2.00e-113	402.00
IUUC-Opu-084010	Oryza punctata	61.77	1.00e-113	402.00
IUUC-Oru-084358	Oryza rufipogon	62.08	2.00e-113	402.00
IUUC-Osa-085296	Oryza sativa	62.08	2.00e-113	402.00
IUUC-Ola-086400	Oryzias latipes	95.58	0.00e+00	634.00
IUUC-Olu-087817	Ostreococcus lucimarinus	75.47	8.00e-142	496.00
IUUC-Oga-088811	Otolemur garnettii	95.58	0.00e+00	636.00
IUUC-Oar-089962	Ovis aries	95.58	0.00e+00	636.00
IUUC-Ptr-091340	Pan troglodytes	95.58	0.00e+00	636.00
IUUC-Pan-091946	Papio anubis	95.58	0.00e+00	636.00
IUUC-Pma-094535	Petromyzon marinus	94.01	0.00e+00	626.00
IUUC-Pno-095100	Phaeosphaeria nodorum	75.94	2.00e-97	347.00
IUUC-Ppa-095588	Physcomitrella patens	75.72	6.00e-140	490.00
IUUC-Pfo-097311	Poecilia formosa	95.90	0.00e+00	637.00
IUUC-Pab-097863	Pongo abelii	95.58	0.00e+00	637.00
IUUC-Pop-099345	Populus trichocarpa	68.11	2.00e-128	451.00
IUUC-Pca-100594	Procavia capensis	94.64	0.00e+00	630.00
IUUC-Ppe-101743	Prunus persica	65.74	2.00e-123	435.00
IUUC-Pva-102746	Pteropus vampyrus	80.44	3.00e-146	511.00
IUUC-Pgr-103375	Puccinia graminis	55.91	8.00e-97	346.00
IUUC-Ptt-103839	Puccinia triticina	73.16	1.00e-137	482.00
IUUC-Pte-104026	Pyrenophora teres	73.08	3.00e-139	487.00
IUUC-Pyt-104584	Pyrenophora triticirepentis	73.08	3.00e-139	488.00
IUUC-Rno-104964	Rattus norvegicus	95.58	0.00e+00	636.00
IUUC-Sce-106224	Saccharomyces cerevisiae	53.82	2.00e-96	345.00
IUUC-Sha-107409	Sarcophilus harrisii	95.58	0.00e+00	636.00
IUUC-Sja-107971	Schizosaccharomyces japonicus	66.45	3.00e-127	447.00
IUUC-Spo-108297	Schizosaccharomyces pombe	64.86	7.00e-124	436.00
IUUC-Ssl-108479	Sclerotinia sclerotiorum	71.15	5.00e-137	480.00
IUUC-Smo-109017	Selaginella moellendorffii	70.57	3.00e-129	454.00
IUUC-Sit-110680	Setaria italica	63.08	3.00e-114	404.00
IUUC-Sly-111496	Solanum lycopersicum	67.50	1.00e-126	446.00
IUUC-Stu-112757	Solanum tuberosum	66.25	3.00e-122	431.00
IUUC-Sar-113173	Sorex araneus	95.58	0.00e+00	636.00
IUUC-Sbi-114681	Sorghum bicolor	62.15	5.00e-114	404.00
IUUC-Sre-115107	Sporisorium reilianum	70.83	7.00e-139	486.00
IUUC-Ssc-116218	Sus scrofa	91.17	1.00e-175	608.00
IUUC-Tru-118202	Takifugu rubripes	93.69	1.00e-180	625.00
IUUC-Tni-120260	Tetraodon nigroviridis	92.74	3.00e-179	620.00
IUUC-Tca-120951	Theobroma cacao	66.15	2.00e-126	445.00
IUUC-Tre-121961	Trichoderma reesei	72.76	2.00e-139	488.00
IUUC-Tvi-122447	Trichoderma virens	72.44	2.00e-138	485.00
IUUC-Tae-123560	Triticum aestivum	61.70	1.00e-112	399.00
IUUC-Tur-126335	Triticum urartu	67.41	2.00e-103	369.00
IUUC-Tme-127105	Tuber melanosporum	69.90	2.00e-127	448.00
IUUC-Tbe-128021	Tupaia belangeri	75.74	7.00e-84	303.00
IUUC-Ttr-128637	Tursiops truncatus	83.91	3.00e-157	547.00
IUUC-Uma-129634	Ustilago maydis	71.79	7.00e-140	489.00
IUUC-Vda-129923	Verticillium dahliae	72.12	4.00e-138	483.00
IUUC-Vpa-130410	Vicugna pacos	74.52	6.00e-109	386.00
IUUC-Vvi-131115	Vitis vinifera	66.36	6.00e-127	446.00
IUUC-Xtr-132105	Xenopus tropicalis	94.64	0.00e+00	634.00
IUUC-Xma-133875	Xiphophorus maculatus	95.58	0.00e+00	634.00
IUUC-Yli-134624	Yarrowia lipolytica	60.44	7.00e-118	416.00
IUUC-Zma-134711	Zea mays	63.38	2.00e-114	405.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence