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Tag Content
UUCD2 ID IUUC-Pab-097845
UUCD1 version UUC-PoA-00949
Ensembl Protein ID ENSPPYP00000013084.1
UniProt Accession Q5RFK9; RN185_PONAB
Genbank Protein ID CAH89448.1
Protein Name E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185
Genbank Nucleotide ID CR857146
Gene Name RNF185
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000011729.1 ENSPPYT00000013617.1 ENSPPYP00000013084.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.80e-07 31.6 39 80
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 39   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 80
           99********.77788*************...666999999****7 PP
   
Organism Pongo abelii
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
 E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
Protein Sequence
(Fasta)
MASKGPSASS SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW 60
PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR 120
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Protein Fasta Sequence


>IUUC-Pab-097845|E3,RING|Pongo abelii
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Nucleotide Sequence
(Fasta)
GGGGCGGCTC CGCGTCATGT GACTGGAGTC CGTGTAGGAG GGGTCGGAGG TCCTACCCAA 60
CAGATTGACG CGGCATTAGT ATTGGCCGTG TAGCCGAAAA ACTGATTGAC TGGGCTGACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-097845|E3,RING|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051865--P:protein autoubiquitination
KEGG pon:100171457
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001042 Aegilops tauschii 52.75 3.00e-24 105.00
IUUC-Aml-001875 Ailuropoda melanoleuca 100.00 3.00e-62 230.00
IUUC-Atr-002721 Amborella trichopoda 55.06 3.00e-25 107.00
IUUC-Apl-003744 Anas platyrhynchos 100.00 4.00e-40 155.00
IUUC-Aly-006065 Arabidopsis lyrata 56.98 1.00e-25 109.00
IUUC-Ath-007401 Arabidopsis thaliana 54.55 1.00e-24 105.00
IUUC-Ame-011667 Astyanax mexicanus 96.79 1.00e-52 198.00
IUUC-Bgr-012018 Blumeria graminis 40.98 2.00e-09 56.20
IUUC-Bta-012734 Bos taurus 100.00 6.00e-62 229.00
IUUC-Bci-013671 Botrytis cinerea 48.98 2.00e-09 57.00
IUUC-Cel-018228 Caenorhabditis elegans 70.59 2.00e-34 138.00
IUUC-Cja-019136 Callithrix jacchus 99.38 9.00e-62 229.00
IUUC-Cfa-020308 Canis familiaris 100.00 3.00e-62 230.00
IUUC-Cpo-021347 Cavia porcellus 98.75 2.00e-61 228.00
IUUC-Cre-022829 Chlamydomonas reinhardtii 56.32 3.00e-26 109.00
IUUC-Csa-023755 Chlorocebus sabaeus 100.00 3.00e-62 231.00
IUUC-Dre-028094 Danio rerio 96.86 3.00e-59 220.00
IUUC-Dno-029402 Dasypus novemcinctus 100.00 3.00e-62 230.00
IUUC-Dor-030373 Dipodomys ordii 100.00 3.00e-62 230.00
IUUC-Dme-031966 Drosophila melanogaster 60.98 8.00e-56 209.00
IUUC-Ete-032786 Echinops telfairi 99.38 4.00e-62 230.00
IUUC-Eca-034261 Equus caballus 100.00 3.00e-62 230.00
IUUC-Eeu-034614 Erinaceus europaeus 90.00 2.00e-49 187.00
IUUC-Fca-036049 Felis catus 100.00 3.00e-62 230.00
IUUC-Fal-037085 Ficedula albicollis 98.76 1.00e-61 228.00
IUUC-Gmo-039369 Gadus morhua 94.51 2.00e-55 207.00
IUUC-Gga-040514 Gallus gallus 99.38 2.00e-61 228.00
IUUC-Gac-041719 Gasterosteus aculeatus 95.73 2.00e-56 211.00
IUUC-Gma-043248 Glycine max 59.30 8.00e-27 113.00
IUUC-Ggo-044504 Gorilla gorilla 100.00 3.00e-62 230.00
IUUC-Hsa-045707 Homo sapiens 100.00 3.00e-62 230.00
IUUC-Hvu-047487 Hordeum vulgare 52.75 7.00e-24 103.00
IUUC-Itr-048343 Ictidomys tridecemlineatus 100.00 5.00e-62 229.00
IUUC-Lch-050658 Latimeria chalumnae 93.12 4.00e-59 220.00
IUUC-Loc-052118 Lepisosteus oculatus 96.95 3.00e-57 214.00
IUUC-Laf-054438 Loxodonta africana 100.00 3.00e-62 230.00
IUUC-Mcc-054641 Macaca mulatta 96.25 5.00e-55 206.00
IUUC-Meu-056828 Macropus eugenii 90.00 6.00e-33 131.00
IUUC-Mor-057077 Magnaporthe oryzae 37.29 2.00e-08 53.50
IUUC-Mpo-057431 Magnaporthe poae 35.29 7.00e-09 55.50
IUUC-Mtr-058107 Medicago truncatula 59.30 2.00e-26 112.00
IUUC-Mga-059554 Meleagris gallopavo 99.38 2.00e-61 228.00
IUUC-Mvi-060316 Microbotryum violaceum 50.88 6.00e-12 64.30
IUUC-Mmr-061662 Microcebus murinus 93.87 3.00e-53 201.00
IUUC-Mdo-062774 Monodelphis domestica 100.00 3.00e-62 230.00
IUUC-Mmu-063372 Mus musculus 100.00 7.00e-62 229.00
IUUC-Mpu-066033 Mustela putorius furo 100.00 1.00e-62 234.00
IUUC-Mlu-067254 Myotis lucifugus 100.00 3.00e-62 230.00
IUUC-Ncr-068628 Neurospora crassa 43.14 6.00e-10 58.50
IUUC-Nle-069850 Nomascus leucogenys 100.00 3.00e-62 230.00
IUUC-Opr-070197 Ochotona princeps 88.12 9.00e-58 215.00
IUUC-Ont-071950 Oreochromis niloticus 97.45 2.00e-58 217.00
IUUC-Oan-073480 Ornithorhynchus anatinus 100.00 3.00e-62 230.00
IUUC-Ocu-073878 Oryctolagus cuniculus 91.88 4.00e-62 230.00
IUUC-Oba-075248 Oryza barthii 55.84 2.00e-23 101.00
IUUC-Ola-086800 Oryzias latipes 97.50 2.00e-55 207.00
IUUC-Oga-088197 Otolemur garnettii 100.00 1.00e-64 239.00
IUUC-Ptr-091106 Pan troglodytes 100.00 3.00e-62 230.00
IUUC-Pan-092671 Papio anubis 100.00 3.00e-62 231.00
IUUC-Psi-093323 Pelodiscus sinensis 100.00 6.00e-62 229.00
IUUC-Pno-094942 Phaeosphaeria nodorum 42.68 4.00e-10 58.50
IUUC-Ppa-095474 Physcomitrella patens 55.91 4.00e-26 111.00
IUUC-Pfo-096943 Poecilia formosa 96.25 1.00e-54 205.00
IUUC-Ppe-102011 Prunus persica 58.14 3.00e-26 111.00
IUUC-Pva-102298 Pteropus vampyrus 100.00 4.00e-62 230.00
IUUC-Pyt-104640 Pyrenophora triticirepentis 37.50 7.00e-10 57.80
IUUC-Rno-105293 Rattus norvegicus 100.00 1.00e-62 231.00
IUUC-Sha-107361 Sarcophilus harrisii 100.00 3.00e-62 230.00
IUUC-Smo-109663 Selaginella moellendorffii 51.69 2.00e-23 100.00
IUUC-Sit-110376 Setaria italica 55.81 1.00e-24 106.00
IUUC-Sar-113669 Sorex araneus 100.00 1.00e-25 107.00
IUUC-Ssc-116228 Sus scrofa 100.00 3.00e-62 230.00
IUUC-Tgu-116886 Taeniopygia guttata 98.76 1.00e-61 228.00
IUUC-Tni-120909 Tetraodon nigroviridis 93.90 2.00e-56 211.00
IUUC-Tae-123670 Triticum aestivum 52.94 4.00e-23 100.00
IUUC-Tur-126676 Triticum urartu 52.94 3.00e-23 101.00
IUUC-Tbe-127360 Tupaia belangeri 100.00 4.00e-43 166.00
IUUC-Ttr-129044 Tursiops truncatus 100.00 3.00e-62 230.00
IUUC-Vda-129983 Verticillium dahliae 43.75 1.00e-08 52.80
IUUC-Vpa-130365 Vicugna pacos 99.38 2.00e-61 227.00
IUUC-Vvi-131449 Vitis vinifera 56.32 3.00e-26 111.00
IUUC-Xtr-131916 Xenopus tropicalis 93.59 3.00e-42 164.00
IUUC-Xma-133333 Xiphophorus maculatus 93.90 5.00e-55 206.00
Created Date 25-Jun-2017

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