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Tag Content
UUCD2 ID IUUC-Bta-012981
UUCD1 version UUC-BoT-01117
Ensembl Protein ID ENSBTAP00000022828.5
UniProt Accession A5D9H7; UBP12_BOVIN
Genbank Protein ID ABQ13036.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-specific-processing protease 12
Genbank Nucleotide ID BT030596
Gene Name USP12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000017179.5 ENSBTAT00000022828.5 ENSBTAP00000022828.5
ENSBTAG00000017179.5 ENSBTAT00000054576.2 ENSBTAP00000050626.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.00e-98 329.9 39 367
Active Site
Position(s) Description Evidence
48 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
316 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +Gl N+gNtCY+NSvLQ+L++++++re +l  +k++      + +k++ll++l++lf+++   k+k +++ p+++++ l+ke+e f++y
   Q: 39   FGLVNFGNTCYCNSVLQALYFCRPFREKVLA-YKSQ------PRKKESLLTCLADLFHSIAtqKKKVGVIPPKKFITRLRKENELFDNY 120
           6******************************.4444......456789************976777779******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +qqDa+Efl++ll+++ + l    ++++++e+++ +    ++ +e++ +  +++++++Fqg+l+++++cl+c+++ss++e+fldls++v
   Q: 121  MQQDAHEFLNYLLNTIADIL----QEERKQEKQNGRLPNGNIDSENNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDV 205
           ********************....4466666666767777788889999999************************************* PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           ++++     s+++cL+ f+++e+l++e kyyce+c++kqea k++k+kklP +L lhLkRf++  + ++ +k++ +v fpleL l  f+
   Q: 206  EQNT-----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRL--FN 287
           ****.....9**********************************************************************66665..77 PP
   S: 266  tspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ts +   + ++ Y+L+avvvH G +++ GHY+a+vk+ ++ WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 288  TSGDA-TNPDRMYDLVAVVVHCGsGPNRGHYIAIVKS-HDFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 367
           77444.4469***************************.555*******************999*****************97 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
 Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Protein Sequence
(Fasta)
MEILMTVSKL ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 60
RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012981|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCTGCCTC CCTCTCCGCC CGCCGCCGCC GCCGCGATTC GGTGGAAGAT GGCGCTGTGC 60
GGATGGAAAT TCTAATGACG GTCTCCAAAC TCGCCTCCAT CTGTACCATG GTAGGTGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012981|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:525655
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001964 Ailuropoda melanoleuca 97.03 0.00e+00 751.00
IUUC-Apl-003411 Anas platyrhynchos 96.44 0.00e+00 744.00
IUUC-Aca-005212 Anolis carolinensis 98.38 0.00e+00 759.00
IUUC-Acl-008239 Aspergillus clavatus 49.67 2.00e-78 286.00
IUUC-Afl-008602 Aspergillus flavus 50.50 3.00e-80 293.00
IUUC-Afu-008816 Aspergillus fumigatus 50.50 2.00e-78 286.00
IUUC-Ani-009137 Aspergillus nidulans 49.83 4.00e-77 282.00
IUUC-Ang-009703 Aspergillus niger 50.17 7.00e-81 295.00
IUUC-Aor-009901 Aspergillus oryzae 50.50 2.00e-80 293.00
IUUC-Ate-010431 Aspergillus terreus 50.50 1.00e-78 287.00
IUUC-Ame-011015 Astyanax mexicanus 92.45 0.00e+00 724.00
IUUC-Bgr-012071 Blumeria graminis 44.70 2.00e-75 276.00
IUUC-Bci-013837 Botrytis cinerea 41.36 3.00e-73 270.00
IUUC-Cja-018831 Callithrix jacchus 99.19 0.00e+00 766.00
IUUC-Cfa-020534 Canis familiaris 98.92 0.00e+00 764.00
IUUC-Cpo-021703 Cavia porcellus 98.87 0.00e+00 733.00
IUUC-Cho-024902 Choloepus hoffmanni 82.77 1.00e-170 591.00
IUUC-Cin-025659 Ciona intestinalis 57.31 2.00e-131 462.00
IUUC-Csv-025828 Ciona savignyi 53.99 3.00e-124 438.00
IUUC-Cgl-026611 Colletotrichum gloeosporioides 43.00 2.00e-75 277.00
IUUC-Dre-027845 Danio rerio 92.45 0.00e+00 727.00
IUUC-Dno-029460 Dasypus novemcinctus 99.15 0.00e+00 734.00
IUUC-Dor-030972 Dipodomys ordii 99.61 3.00e-152 531.00
IUUC-Dse-031470 Dothistroma septosporum 48.87 4.00e-78 286.00
IUUC-Ete-033125 Echinops telfairi 78.91 2.00e-132 465.00
IUUC-Eca-033439 Equus caballus 99.44 0.00e+00 736.00
IUUC-Fca-035524 Felis catus 99.15 0.00e+00 736.00
IUUC-Fal-036833 Ficedula albicollis 95.64 0.00e+00 740.00
IUUC-Gmo-038763 Gadus morhua 92.20 0.00e+00 727.00
IUUC-Gga-041151 Gallus gallus 98.64 0.00e+00 766.00
IUUC-Gac-041967 Gasterosteus aculeatus 92.74 0.00e+00 730.00
IUUC-Hsa-045700 Homo sapiens 99.19 0.00e+00 766.00
IUUC-Itr-049082 Ictidomys tridecemlineatus 99.44 0.00e+00 739.00
IUUC-Lch-050237 Latimeria chalumnae 91.06 0.00e+00 675.00
IUUC-Lpe-051368 Leersia perrieri 58.90 4.00e-122 431.00
IUUC-Loc-051968 Lepisosteus oculatus 95.95 0.00e+00 749.00
IUUC-Lma-053300 Leptosphaeria maculans 47.73 2.00e-79 290.00
IUUC-Laf-053887 Loxodonta africana 99.19 0.00e+00 766.00
IUUC-Mcc-055701 Macaca mulatta 98.92 0.00e+00 764.00
IUUC-Mor-057072 Magnaporthe oryzae 43.97 3.00e-76 279.00
IUUC-Mga-059195 Meleagris gallopavo 95.92 0.00e+00 745.00
IUUC-Mmr-060751 Microcebus murinus 99.19 0.00e+00 766.00
IUUC-Mdo-062735 Monodelphis domestica 97.04 0.00e+00 749.00
IUUC-Mmu-063263 Mus musculus 97.84 0.00e+00 757.00
IUUC-Mlu-068128 Myotis lucifugus 99.44 0.00e+00 736.00
IUUC-Nfi-068611 Neosartorya fischeri 50.50 2.00e-78 286.00
IUUC-Ncr-068699 Neurospora crassa 44.30 4.00e-76 279.00
IUUC-Nle-069767 Nomascus leucogenys 99.44 0.00e+00 739.00
IUUC-Opr-070582 Ochotona princeps 92.09 0.00e+00 667.00
IUUC-Ont-072658 Oreochromis niloticus 93.01 0.00e+00 732.00
IUUC-Oan-073372 Ornithorhynchus anatinus 98.02 0.00e+00 728.00
IUUC-Ocu-074322 Oryctolagus cuniculus 96.49 0.00e+00 743.00
IUUC-Ola-087418 Oryzias latipes 93.01 0.00e+00 733.00
IUUC-Oga-088298 Otolemur garnettii 96.23 0.00e+00 739.00
IUUC-Oar-090269 Ovis aries 98.07 0.00e+00 749.00
IUUC-Ptr-090467 Pan troglodytes 99.19 0.00e+00 766.00
IUUC-Pan-092437 Papio anubis 96.47 0.00e+00 738.00
IUUC-Psi-092993 Pelodiscus sinensis 96.15 0.00e+00 731.00
IUUC-Pma-094388 Petromyzon marinus 87.94 0.00e+00 688.00
IUUC-Pno-095044 Phaeosphaeria nodorum 48.51 4.00e-79 289.00
IUUC-Pfo-097052 Poecilia formosa 93.01 0.00e+00 732.00
IUUC-Pab-097797 Pongo abelii 99.19 0.00e+00 766.00
IUUC-Pca-100835 Procavia capensis 90.49 2.00e-175 607.00
IUUC-Pgr-103306 Puccinia graminis 52.79 8.00e-96 345.00
IUUC-Pte-104356 Pyrenophora teres 48.04 2.00e-78 286.00
IUUC-Pyt-104709 Pyrenophora triticirepentis 48.37 5.00e-79 288.00
IUUC-Rno-106060 Rattus norvegicus 98.59 0.00e+00 730.00
IUUC-Sce-106196 Saccharomyces cerevisiae 38.18 1.00e-55 211.00
IUUC-Sha-107087 Sarcophilus harrisii 99.19 0.00e+00 766.00
IUUC-Sja-107684 Schizosaccharomyces japonicus 45.73 3.00e-67 249.00
IUUC-Spo-108095 Schizosaccharomyces pombe 46.90 1.00e-75 277.00
IUUC-Sar-113216 Sorex araneus 98.59 0.00e+00 725.00
IUUC-Sre-115197 Sporisorium reilianum 50.53 3.00e-81 297.00
IUUC-Ssc-116321 Sus scrofa 94.91 0.00e+00 737.00
IUUC-Tgu-117482 Taeniopygia guttata 95.37 0.00e+00 715.00
IUUC-Tru-118613 Takifugu rubripes 92.74 0.00e+00 730.00
IUUC-Tsy-119520 Tarsius syrichta 88.63 7.00e-131 459.00
IUUC-Tni-120293 Tetraodon nigroviridis 92.74 0.00e+00 730.00
IUUC-Tre-122226 Trichoderma reesei 45.25 1.00e-75 277.00
IUUC-Tvi-122330 Trichoderma virens 45.57 3.00e-76 279.00
IUUC-Tme-126890 Tuber melanosporum 46.75 2.00e-92 333.00
IUUC-Tbe-127783 Tupaia belangeri 98.31 0.00e+00 717.00
IUUC-Ttr-129083 Tursiops truncatus 99.46 0.00e+00 768.00
IUUC-Vda-129736 Verticillium dahliae 39.03 5.00e-59 222.00
IUUC-Vpa-130391 Vicugna pacos 95.47 0.00e+00 701.00
IUUC-Xtr-132082 Xenopus tropicalis 91.33 0.00e+00 712.00
IUUC-Xma-133475 Xiphophorus maculatus 93.01 0.00e+00 732.00
IUUC-Yli-134632 Yarrowia lipolytica 46.74 4.00e-80 292.00
Created Date 25-Jun-2017

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