iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091162

Ensembl Protein ID

ENSPTRP00000010269.4

UniProt Accession

H2Q7T3; H2Q7T3_PANTR

Genbank Protein ID

ENSPTRP00000010269

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03092840

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000006039.5	ENSPTRT00000011095.4	ENSPTRP00000010269.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-15	56.6	136	190

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 136  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNGRTGWFPSNYVREVK 190
           78999*********************7..999*******..8**************996 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

SVLQVYPEPR SESECLSNIR EFLRGCGASL RLEVSAGGHG PRLYFCLFNF SFQTFDANDL 60
YQGQNFNKVL SSLVTLNKVT ADIGLGSDSV CARPSSHRIK SFDSLGSQSL HTRTSKLFQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGTGTTGC AGGTCTACCC CGAGCCCCGG AGCGAGAGCG AGTGCCTGAG CAACATCCGC 60
GAGTTCCTGC GCGGCTGCGG GGCTTCCCTG CGGCTGGAGG TGAGCGCGGG CGGCCACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	94.01	0.00e+00	1280.00
IUUC-Apl-003960	Anas platyrhynchos	58.30	0.00e+00	737.00
IUUC-Aca-004591	Anolis carolinensis	88.65	0.00e+00	1144.00
IUUC-Ago-008003	Ashbya gossypii	25.00	7.00e-15	75.90
IUUC-Ame-010759	Astyanax mexicanus	73.23	0.00e+00	1033.00
IUUC-Bta-013328	Bos taurus	89.46	0.00e+00	1212.00
IUUC-Bci-013864	Botrytis cinerea	41.54	9.00e-12	66.20
IUUC-Cja-018742	Callithrix jacchus	98.73	0.00e+00	1277.00
IUUC-Cfa-020756	Canis familiaris	94.30	0.00e+00	1139.00
IUUC-Cpo-021284	Cavia porcellus	89.99	0.00e+00	1184.00
IUUC-Csa-023162	Chlorocebus sabaeus	96.49	0.00e+00	1299.00
IUUC-Cho-024736	Choloepus hoffmanni	73.62	5.00e-173	601.00
IUUC-Cin-025535	Ciona intestinalis	39.74	3.00e-93	335.00
IUUC-Cne-026866	Cryptococcus neoformans	50.79	2.00e-13	72.00
IUUC-Dre-028646	Danio rerio	73.11	0.00e+00	1025.00
IUUC-Dno-029461	Dasypus novemcinctus	92.57	0.00e+00	1241.00
IUUC-Dor-030623	Dipodomys ordii	82.22	0.00e+00	1071.00
IUUC-Dme-032219	Drosophila melanogaster	46.51	4.00e-103	369.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	803.00
IUUC-Eca-034137	Equus caballus	96.08	0.00e+00	1189.00
IUUC-Eeu-035269	Erinaceus europaeus	57.50	4.00e-81	295.00
IUUC-Fca-035742	Felis catus	95.23	0.00e+00	1112.00
IUUC-Fal-037205	Ficedula albicollis	93.65	0.00e+00	1022.00
IUUC-Fox-037757	Fusarium oxysporum	38.89	2.00e-11	65.10
IUUC-Gmo-039475	Gadus morhua	72.69	0.00e+00	892.00
IUUC-Gga-040539	Gallus gallus	92.97	0.00e+00	970.00
IUUC-Gac-042615	Gasterosteus aculeatus	70.23	0.00e+00	835.00
IUUC-Ggo-044470	Gorilla gorilla	98.72	0.00e+00	1266.00
IUUC-Hsa-046398	Homo sapiens	96.81	0.00e+00	1325.00
IUUC-Lch-049517	Latimeria chalumnae	60.03	0.00e+00	773.00
IUUC-Loc-052146	Lepisosteus oculatus	81.92	0.00e+00	1114.00
IUUC-Laf-053891	Loxodonta africana	93.27	0.00e+00	1229.00
IUUC-Mcc-055483	Macaca mulatta	96.54	0.00e+00	1323.00
IUUC-Meu-056285	Macropus eugenii	49.66	1.00e-122	434.00
IUUC-Mtr-058576	Medicago truncatula	56.82	2.00e-10	59.70
IUUC-Mla-059044	Melampsora laricipopulina	26.58	8.00e-19	89.70
IUUC-Mga-059410	Meleagris gallopavo	92.81	0.00e+00	1166.00
IUUC-Mmr-060758	Microcebus murinus	93.87	0.00e+00	1232.00
IUUC-Mdo-061900	Monodelphis domestica	89.87	0.00e+00	1164.00
IUUC-Mmu-063849	Mus musculus	91.08	0.00e+00	1202.00
IUUC-Mpu-065876	Mustela putorius furo	93.96	0.00e+00	1125.00
IUUC-Mlu-067970	Myotis lucifugus	95.64	0.00e+00	1187.00
IUUC-Nle-069685	Nomascus leucogenys	95.86	0.00e+00	1067.00
IUUC-Opr-071132	Ochotona princeps	64.47	0.00e+00	728.00
IUUC-Ont-071815	Oreochromis niloticus	74.02	0.00e+00	1024.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.18	0.00e+00	1030.00
IUUC-Ocu-074852	Oryctolagus cuniculus	57.14	0.00e+00	716.00
IUUC-Ola-086663	Oryzias latipes	73.01	0.00e+00	959.00
IUUC-Oga-088103	Otolemur garnettii	95.23	0.00e+00	1154.00
IUUC-Oar-089339	Ovis aries	56.55	0.00e+00	706.00
IUUC-Pan-092093	Papio anubis	84.78	0.00e+00	1144.00
IUUC-Psi-093116	Pelodiscus sinensis	58.44	0.00e+00	747.00
IUUC-Pma-094261	Petromyzon marinus	66.25	4.00e-125	440.00
IUUC-Pfo-096736	Poecilia formosa	69.42	0.00e+00	925.00
IUUC-Pab-097641	Pongo abelii	95.89	0.00e+00	1234.00
IUUC-Pca-100997	Procavia capensis	53.74	4.00e-160	558.00
IUUC-Pva-102819	Pteropus vampyrus	89.35	0.00e+00	1192.00
IUUC-Pgr-103400	Puccinia graminis	27.00	5.00e-20	93.60
IUUC-Pyt-104567	Pyrenophora triticirepentis	42.86	2.00e-10	61.60
IUUC-Rno-106099	Rattus norvegicus	90.81	0.00e+00	1173.00
IUUC-Sha-106845	Sarcophilus harrisii	92.25	0.00e+00	1117.00
IUUC-Sar-113420	Sorex araneus	56.63	0.00e+00	672.00
IUUC-Ssc-116036	Sus scrofa	94.15	0.00e+00	1123.00
IUUC-Tgu-117498	Taeniopygia guttata	90.93	0.00e+00	1212.00
IUUC-Tru-118278	Takifugu rubripes	72.20	0.00e+00	963.00
IUUC-Tsy-118990	Tarsius syrichta	94.91	0.00e+00	972.00
IUUC-Tni-120852	Tetraodon nigroviridis	72.31	0.00e+00	909.00
IUUC-Tbe-127994	Tupaia belangeri	47.38	9.00e-163	567.00
IUUC-Ttr-128922	Tursiops truncatus	88.35	0.00e+00	1152.00
IUUC-Vpa-130144	Vicugna pacos	50.59	2.00e-170	592.00
IUUC-Xtr-132012	Xenopus tropicalis	81.78	0.00e+00	991.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence