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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063651
Ensembl Protein ID ENSMUSP00000019439.7
UniProt Accession Q8K304; Q3TA74; Q9DCF3; TM129_MOUSE
Genbank Protein ID BAB22394.1; BAE42795.1; AAH29088.1; AAH94042.1
Protein Name E3 ubiquitin-protein ligase TM129; RING-type E3 ubiquitin transferase TM129
Genbank Nucleotide ID AK002836; AK172044; BC029088; BC094042
Gene Name Tmem129
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000019295.8 ENSMUST00000019439.8 ENSMUSP00000019439.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 89.23 0.00e+00 640.00 IUUC-Hsa-046951
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
 E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
Protein Sequence
(Fasta)
MDSPEVTFTL AYLVFAVCFV FTPNEFYSAG LTVQNLLSGW LGSEDAAFVP YHLRRTSATL 60
LCHSLLPLGY YMGMCFAASE KQLYSPGQAP EAWQLFLLLA VTLPLLSCTL IYYWSWDRWT 120
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Protein Fasta Sequence


>IUUC-Mmu-063651|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGAGCGTTG GGGCGTATGG GAACTGTGGT CTAGCATCGG GGGCCGAGAG GGCTTGTTGG 60
TAGCCAGTGA CTGTGAGAGC CATCATGGCC CAGAAAATCT CATGGTCGGC CGCGAATGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063651|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018801--Tmpp129
Pfam

PF10272--Tmpp129
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0000209--P:protein polyubiquitination
GO:0006986--P:response to unfolded protein
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG mmu:68366
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001914 Ailuropoda melanoleuca 90.86 0.00e+00 657.00
IUUC-Apl-003347 Anas platyrhynchos 74.93 2.00e-157 548.00
IUUC-Ame-010846 Astyanax mexicanus 65.83 5.00e-143 500.00
IUUC-Bta-012669 Bos taurus 87.57 0.00e+00 644.00
IUUC-Cel-018636 Caenorhabditis elegans 27.65 1.00e-17 84.00
IUUC-Cja-019250 Callithrix jacchus 86.46 0.00e+00 628.00
IUUC-Cfa-020230 Canis familiaris 90.88 0.00e+00 661.00
IUUC-Cpo-022023 Cavia porcellus 90.88 0.00e+00 669.00
IUUC-Csa-023823 Chlorocebus sabaeus 88.40 0.00e+00 643.00
IUUC-Cin-025745 Ciona intestinalis 42.98 9.00e-87 313.00
IUUC-Csv-025856 Ciona savignyi 41.92 1.00e-85 310.00
IUUC-Dre-028722 Danio rerio 66.85 5.00e-146 510.00
IUUC-Dno-029635 Dasypus novemcinctus 84.51 8.00e-143 499.00
IUUC-Dor-030657 Dipodomys ordii 90.61 0.00e+00 661.00
IUUC-Dme-031679 Drosophila melanogaster 31.95 2.00e-60 226.00
IUUC-Ete-032708 Echinops telfairi 83.63 4.00e-106 377.00
IUUC-Eca-033244 Equus caballus 88.78 1.00e-150 525.00
IUUC-Fca-035762 Felis catus 90.88 0.00e+00 661.00
IUUC-Fal-036939 Ficedula albicollis 75.41 4.00e-161 560.00
IUUC-Gmo-039282 Gadus morhua 65.44 3.00e-99 354.00
IUUC-Gga-040148 Gallus gallus 75.97 2.00e-161 561.00
IUUC-Gac-042319 Gasterosteus aculeatus 63.59 5.00e-137 480.00
IUUC-Hsa-046951 Homo sapiens 89.23 0.00e+00 651.00
IUUC-Itr-048030 Ictidomys tridecemlineatus 91.16 0.00e+00 662.00
IUUC-Lch-050659 Latimeria chalumnae 74.65 5.00e-163 566.00
IUUC-Loc-052168 Lepisosteus oculatus 72.93 1.00e-162 565.00
IUUC-Laf-054003 Loxodonta africana 85.91 0.00e+00 634.00
IUUC-Mcc-055211 Macaca mulatta 88.12 0.00e+00 642.00
IUUC-Mga-059834 Meleagris gallopavo 74.16 8.00e-128 449.00
IUUC-Mdo-062514 Monodelphis domestica 81.16 2.00e-175 608.00
IUUC-Mpu-066843 Mustela putorius furo 91.44 0.00e+00 666.00
IUUC-Mlu-067390 Myotis lucifugus 84.02 2.00e-96 345.00
IUUC-Nle-069501 Nomascus leucogenys 88.00 5.00e-152 530.00
IUUC-Ont-071406 Oreochromis niloticus 62.13 5.00e-133 467.00
IUUC-Oan-073199 Ornithorhynchus anatinus 74.31 9.00e-145 506.00
IUUC-Ola-086495 Oryzias latipes 61.64 9.00e-132 462.00
IUUC-Oga-087914 Otolemur garnettii 92.27 0.00e+00 678.00
IUUC-Oar-089585 Ovis aries 69.02 1.00e-108 385.00
IUUC-Ptr-090660 Pan troglodytes 88.10 8.00e-149 519.00
IUUC-Pan-092206 Papio anubis 88.67 0.00e+00 644.00
IUUC-Psi-093829 Pelodiscus sinensis 77.18 1.00e-164 572.00
IUUC-Pma-094399 Petromyzon marinus 62.36 2.00e-130 459.00
IUUC-Pfo-096826 Poecilia formosa 59.84 9.00e-129 453.00
IUUC-Pab-097827 Pongo abelii 88.95 0.00e+00 652.00
IUUC-Pca-100182 Procavia capensis 86.74 0.00e+00 629.00
IUUC-Pva-103236 Pteropus vampyrus 83.93 1.00e-50 193.00
IUUC-Rno-105429 Rattus norvegicus 97.79 0.00e+00 707.00
IUUC-Sha-107104 Sarcophilus harrisii 80.20 1.00e-142 498.00
IUUC-Ssc-116316 Sus scrofa 88.67 2.00e-177 614.00
IUUC-Tgu-116563 Taeniopygia guttata 74.86 3.00e-160 557.00
IUUC-Tbe-127698 Tupaia belangeri 90.78 4.00e-156 543.00
IUUC-Ttr-128759 Tursiops truncatus 85.64 5.00e-177 613.00
IUUC-Xtr-132390 Xenopus tropicalis 75.69 5.00e-167 580.00
Created Date 25-Jun-2017

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