iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117763

UUCD1 version

UUC-TaR-00324

Ensembl Protein ID

ENSTRUP00000016582.1

UniProt Accession

H2SVZ4; H2SVZ4_TAKRU

Protein Name

Uncharacterized protein

Gene Name

ube3a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006748.1	ENSTRUT00000016654.1	ENSTRUP00000016582.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-101	340.3	483	809

Active Site

Position(s)	Description	Evidence
778	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +sdlkk+l+vef+gE+g+d gG+++ef++l+++e++npd+g+f+y+++ +  ++ + +s     e++  ++++G +lg+a++++ +ldl
   Q: 483  PSDLKKQLFVEFEGEQGVDEGGLSKEFFQLVLEEIFNPDIGMFTYDDETQVFWFNS-SSL----ENEAQYTLIGLVLGLAIYNNCILDL 566
           689*******************************************9999998844.454....67999******************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++  +yk+l+gkk ++ dl++ +p l +slk ++e+a  ++ee ++ ltf+  +++++g+   ++Lk++Ge+ipVt+eN++e+v+l++
   Q: 567  HFPMIVYKKLMGKKGTYMDLSDSHPVLSQSLKGLREYA-GNVEE-DMSLTFQiSHTDLFGNPVLYDLKENGEQIPVTKENRQEFVDLYT 653
           *************************************5.56666.48999984456679****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y l++++++q++af++Gf  v +++ l  lF++eelellicG++++d+++l+++t+y+ggy++d + i+ Fwe++++f++e+++ fLq
   Q: 654  DYMLNKSVETQFKAFKKGFLMVTQESpLKHLFRPEELELLICGSKKLDFDALEETTEYDGGYSKDAQIIKDFWETIRSFEEEQKRLFLQ 742
           ***********************99946679********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F++g+ r+P+gG+ +lk   ++i k++sd drlP+s+TC+n L LPeYssk +l+e+Ll Ai+++kgF++
   Q: 743  FISGTVRAPVGGLGKLK---MTIAKNGSDtDRLPTSHTCYNILLLPEYSSKAKLRERLLKAITYAKGFGM 809
           *****************...7888877777**************************************98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

SHRKRAAAKH LIEHYFLQLT DGCGNADCRN EFCASCRDFR PLDNNTAAVK ALELFKINAK 60
LCRPPPLNRE SHSPSLGCGP SEYSQLELSD ADFSDVHYLT ETTVCMILSF CEEEGDYSAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACACAGGA AGAGGGCCGC TGCTAAACAT CTAATTGAGC ACTACTTCCT GCAGTTAACA 60
GACGGCTGCG GAAACGCTGA CTGCAGAAAT GAGTTCTGTG CATCGTGTCG TGATTTTCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003144	Amborella trichopoda	44.44	3.00e-95	342.00
IUUC-Ago-007908	Ashbya gossypii	35.25	2.00e-69	257.00
IUUC-Gmo-038840	Gadus morhua	67.26	0.00e+00	1114.00
IUUC-Gac-042293	Gasterosteus aculeatus	72.46	0.00e+00	1191.00
IUUC-Ont-072087	Oreochromis niloticus	74.97	0.00e+00	1256.00
IUUC-Ola-086833	Oryzias latipes	73.13	0.00e+00	1156.00
IUUC-Pfo-096868	Poecilia formosa	73.22	0.00e+00	1210.00
IUUC-Ptt-103736	Puccinia triticina	38.65	5.00e-76	279.00
IUUC-Tni-120640	Tetraodon nigroviridis	88.29	0.00e+00	1378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence