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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063389
UUCD1 version UUC-MuM-00005
Ensembl Protein ID ENSMUSP00000028728.5
UniProt Accession O70481; A2AQ54; Q5BKR8; Q792M3; Q8BN40; Q8C5K3; UBR1_MOUSE
Genbank Protein ID AAC40165.1; AAC23678.1; CAM19009.1; CAM19009.1; CAM21400.1; CAM21400.1; BAC37160.1; BAC40933.1; AAH90969.1
Protein Name E3 ubiquitin-protein ligase UBR1; N-recognin-1; RING-type E3 ubiquitin transferase UBR1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
Genbank Nucleotide ID AF061555; AH006182; AL844548; AL935168; AL935168; AL844548; AK078173; AK089616; BC090969
Gene Name Ubr1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027272.5 ENSMUST00000028728.5 ENSMUSP00000028728.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19008229
E3 activity/N-recognin/UBR-box UBR 19008229
E3 activity/N-recognin/N-domain N-domain 19008229
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.80e-08 34.0 1101 1204
E3 activity/N-recognin/N-domain 2.50e-40 137.6 226 302
E3 activity/N-recognin/UBR-box 6.90e-31 107.7 97 167
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiC.......................................ledf........kdgplvlpCgHvfhadClqkw........... 29
           C++C                                       l            +g+++++CgHv+ha C+qk+           
   Q: 1101 CILCqeeqevklennamvlsacvqkstaltqhrgkpvdhlgetL--DplfmdpdlAHGTYTGSCGHVMHAVCWQKYfeavqlssqqr 1185
           88883333333333333333333333333333333333322221..022333333447999************************** PP
   S: 30   ..pglknssskefrCPlCr 46
             ++l +++s+e +CPlC+
   Q: 1186 ihVDLFDLESGEYLCPLCK 1204
           ******************7 PP
   

   E3 activity/N-recognin/N-domain
   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 226  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGVYATCQEAKEDIKSHSENVSQHPLHVEV 302
           9**************************************************************************97 PP
   

   E3 activity/N-recognin/UBR-box
   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C++++
   Q: 97   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVDHE 167
           68******************************************************************996 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity).
 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity).
Protein Sequence
(Fasta)
MADEEMDGAE RMDVSPEPPL APQRPASWWD QQVDFYTAFL HHLAQLVPEI YFAEMDPDLE 60
KQEESVQMSI LTPLEWYLFG EDPDICLEKL KHSGAFQLCG KVFKSGETTY SCRDCAIDPT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063389|E3,RING;E3,UBR-box;E3,N-domain|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTGACTTCA GGGGCCGTCG TAAAAGTGTC GTCCCTGTCG CGTCGGGCCG GCCACAGGTT 60
TCCGCTAGCT GGCGGCCGGG GGTCGGGAAC TGCGGGCGTT CGTTTCCCTT AAGATGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063389|E3,RING;E3,UBR-box;E3,N-domain|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02617--ClpS
PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway
KEGG mmu:22222
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001354 Ailuropoda melanoleuca 91.29 0.00e+00 3233.00
IUUC-Apl-004160 Anas platyrhynchos 77.69 0.00e+00 2707.00
IUUC-Aca-004982 Anolis carolinensis 74.68 0.00e+00 2624.00
IUUC-Acl-008055 Aspergillus clavatus 24.21 1.00e-34 143.00
IUUC-Afu-008929 Aspergillus fumigatus 23.59 2.00e-52 202.00
IUUC-Ani-009334 Aspergillus nidulans 23.55 7.00e-52 200.00
IUUC-Ate-010550 Aspergillus terreus 23.64 1.00e-48 189.00
IUUC-Ame-011231 Astyanax mexicanus 57.40 0.00e+00 1888.00
IUUC-Bgr-011999 Blumeria graminis 23.27 3.00e-47 185.00
IUUC-Bta-012347 Bos taurus 91.24 0.00e+00 3228.00
IUUC-Bci-013834 Botrytis cinerea 24.02 4.00e-32 134.00
IUUC-Cja-018911 Callithrix jacchus 88.15 0.00e+00 3089.00
IUUC-Cfa-020991 Canis familiaris 92.32 0.00e+00 3270.00
IUUC-Cpo-021448 Cavia porcellus 90.20 0.00e+00 3184.00
IUUC-Cre-022930 Chlamydomonas reinhardtii 46.15 1.50e-02 31.60
IUUC-Csa-024255 Chlorocebus sabaeus 92.67 0.00e+00 2691.00
IUUC-Cho-024550 Choloepus hoffmanni 70.69 0.00e+00 2385.00
IUUC-Cgl-026605 Colletotrichum gloeosporioides 24.30 3.00e-52 201.00
IUUC-Dno-029427 Dasypus novemcinctus 90.70 0.00e+00 3127.00
IUUC-Dor-031073 Dipodomys ordii 78.42 0.00e+00 1364.00
IUUC-Ete-032318 Echinops telfairi 74.67 0.00e+00 1242.00
IUUC-Eca-033348 Equus caballus 91.50 0.00e+00 3002.00
IUUC-Eeu-034664 Erinaceus europaeus 82.47 0.00e+00 2900.00
IUUC-Fca-035604 Felis catus 87.35 0.00e+00 1506.00
IUUC-Fal-037333 Ficedula albicollis 77.34 0.00e+00 2674.00
IUUC-Fox-037984 Fusarium oxysporum 27.32 2.00e-40 162.00
IUUC-Fso-038463 Fusarium solani 25.07 1.00e-42 169.00
IUUC-Gmo-039363 Gadus morhua 55.96 0.00e+00 1642.00
IUUC-Gga-040486 Gallus gallus 76.53 0.00e+00 2628.00
IUUC-Gac-041985 Gasterosteus aculeatus 56.87 0.00e+00 1746.00
IUUC-Ggo-044704 Gorilla gorilla 85.81 0.00e+00 2526.00
IUUC-Hsa-046753 Homo sapiens 92.15 0.00e+00 3264.00
IUUC-Itr-048410 Ictidomys tridecemlineatus 92.37 0.00e+00 3247.00
IUUC-Lch-049904 Latimeria chalumnae 61.68 0.00e+00 2103.00
IUUC-Loc-052624 Lepisosteus oculatus 61.33 0.00e+00 2065.00
IUUC-Laf-053857 Loxodonta africana 88.76 0.00e+00 3117.00
IUUC-Mcc-054873 Macaca mulatta 92.26 0.00e+00 3219.00
IUUC-Meu-056858 Macropus eugenii 66.04 0.00e+00 1021.00
IUUC-Mor-057051 Magnaporthe oryzae 23.76 9.00e-47 183.00
IUUC-Mga-059917 Meleagris gallopavo 76.81 0.00e+00 2736.00
IUUC-Mmr-061128 Microcebus murinus 88.45 0.00e+00 3071.00
IUUC-Mdo-062306 Monodelphis domestica 79.70 0.00e+00 2788.00
IUUC-Mpu-065983 Mustela putorius furo 91.80 0.00e+00 3276.00
IUUC-Mlu-068013 Myotis lucifugus 88.06 0.00e+00 3125.00
IUUC-Nfi-068403 Neosartorya fischeri 23.49 7.00e-53 203.00
IUUC-Nle-070031 Nomascus leucogenys 92.49 0.00e+00 3275.00
IUUC-Opr-070551 Ochotona princeps 69.22 0.00e+00 1341.00
IUUC-Ont-072035 Oreochromis niloticus 58.12 0.00e+00 1973.00
IUUC-Ocu-074930 Oryctolagus cuniculus 87.09 0.00e+00 3066.00
IUUC-Oba-075295 Oryza barthii 38.54 7.00e-14 74.30
IUUC-Ogl-077571 Oryza glaberrima 24.50 4.00e-26 115.00
IUUC-Ogu-078497 Oryza glumaepatula 38.54 6.00e-14 74.30
IUUC-Oin-079343 Oryza indica 38.54 7.00e-14 74.30
IUUC-Oni-083099 Oryza nivara 38.54 7.00e-14 74.30
IUUC-Oru-084471 Oryza rufipogon 38.54 7.00e-14 74.30
IUUC-Osa-085336 Oryza sativa 24.15 1.00e-25 112.00
IUUC-Ola-086683 Oryzias latipes 57.41 0.00e+00 1911.00
IUUC-Oga-088017 Otolemur garnettii 88.47 0.00e+00 3096.00
IUUC-Oar-089557 Ovis aries 90.92 0.00e+00 3221.00
IUUC-Ptr-091366 Pan troglodytes 91.12 0.00e+00 3240.00
IUUC-Pan-092184 Papio anubis 92.20 0.00e+00 3217.00
IUUC-Psi-093720 Pelodiscus sinensis 78.05 0.00e+00 2673.00
IUUC-Pfo-097124 Poecilia formosa 57.84 0.00e+00 1941.00
IUUC-Pab-098586 Pongo abelii 92.43 0.00e+00 3271.00
IUUC-Pop-099184 Populus trichocarpa 43.16 6.00e-13 68.60
IUUC-Pca-100673 Procavia capensis 83.96 0.00e+00 1713.00
IUUC-Pva-102724 Pteropus vampyrus 85.49 0.00e+00 2986.00
IUUC-Pte-104174 Pyrenophora teres 23.42 3.00e-48 188.00
IUUC-Pyt-104431 Pyrenophora triticirepentis 23.32 3.00e-47 185.00
IUUC-Rno-105474 Rattus norvegicus 93.53 0.00e+00 2452.00
IUUC-Sha-106993 Sarcophilus harrisii 80.24 0.00e+00 2865.00
IUUC-Sar-113447 Sorex araneus 85.99 0.00e+00 2113.00
IUUC-Sre-115045 Sporisorium reilianum 24.42 9.00e-45 177.00
IUUC-Ssc-115768 Sus scrofa 88.41 0.00e+00 2901.00
IUUC-Tgu-116949 Taeniopygia guttata 72.45 0.00e+00 2465.00
IUUC-Tru-117782 Takifugu rubripes 57.20 0.00e+00 1930.00
IUUC-Tsy-119177 Tarsius syrichta 81.03 0.00e+00 2193.00
IUUC-Tni-120884 Tetraodon nigroviridis 53.32 0.00e+00 1759.00
IUUC-Tre-122137 Trichoderma reesei 25.23 1.00e-59 226.00
IUUC-Tbe-128088 Tupaia belangeri 80.10 0.00e+00 1228.00
IUUC-Ttr-129062 Tursiops truncatus 85.78 0.00e+00 3002.00
IUUC-Uma-129344 Ustilago maydis 23.67 3.00e-56 215.00
IUUC-Vpa-130578 Vicugna pacos 83.61 0.00e+00 2893.00
IUUC-Vvi-130900 Vitis vinifera 43.75 4.00e-12 65.90
IUUC-Xtr-132244 Xenopus tropicalis 61.10 0.00e+00 2093.00
Created Date 25-Jun-2017

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