iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040970

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 1

Genbank Nucleotide ID

AADN04000130

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000007158.3	ENSGALT00000011595.3	ENSGALP00000011581.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.80e-13	49.9	161	206

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +l+  ++ +Lq+LCR++I++++g+++l   +++PL+++LkdYL+++++q
   Q: 161  PLRKVRVQPLQELCRKSIVKTFGRENL---NQIPLNPVLKDYLKSFPFQ 206
           5566689********************...****************986 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MVAHSKVSAD NAVAADPRCL LDPPARDRSQ ARGYRGTGRP GAAQAPSSTH FRTFRSQADF 60
SSITRASSLL DACGFYWGPL TVSAAHEKLK SEPEGTFLIR DSTQKNCFFA ISVKTATGPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGGAAGAC CGCATCCGCT GGCCTAGGCT GTAGGATGGT AGCGCACAGC AAGGTGTCAG 60
CAGACAATGC AGTTGCAGCA GACCCGCGAT GTCTACTTGA CCCTCCGGCA CGGGATCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

gga:416630

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	66.67	1.00e-61	228.00
IUUC-Apl-003313	Anas platyrhynchos	96.62	7.00e-117	412.00
IUUC-Aca-005109	Anolis carolinensis	68.35	3.00e-64	237.00
IUUC-Ame-011550	Astyanax mexicanus	59.88	3.00e-57	214.00
IUUC-Bta-013411	Bos taurus	72.33	2.00e-71	261.00
IUUC-Cja-019595	Callithrix jacchus	61.14	3.00e-73	267.00
IUUC-Cfa-020563	Canis familiaris	72.33	3.00e-71	260.00
IUUC-Cpo-021374	Cavia porcellus	72.33	2.00e-71	261.00
IUUC-Csa-023333	Chlorocebus sabaeus	61.03	1.00e-72	265.00
IUUC-Dre-028507	Danio rerio	47.55	1.00e-50	192.00
IUUC-Dno-029406	Dasypus novemcinctus	62.50	5.00e-72	263.00
IUUC-Ete-032399	Echinops telfairi	60.77	8.00e-71	259.00
IUUC-Eca-033519	Equus caballus	61.14	1.00e-69	255.00
IUUC-Fal-036726	Ficedula albicollis	93.24	5.00e-104	369.00
IUUC-Gmo-039667	Gadus morhua	43.36	2.00e-24	105.00
IUUC-Gac-041838	Gasterosteus aculeatus	44.75	2.00e-36	144.00
IUUC-Ggo-045569	Gorilla gorilla	61.35	1.00e-73	268.00
IUUC-Hsa-046010	Homo sapiens	61.14	3.00e-72	264.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	72.96	7.00e-72	262.00
IUUC-Lch-050219	Latimeria chalumnae	69.81	4.00e-66	243.00
IUUC-Loc-052494	Lepisosteus oculatus	58.45	1.00e-66	245.00
IUUC-Laf-054219	Loxodonta africana	71.32	1.00e-56	211.00
IUUC-Mcc-054830	Macaca mulatta	73.58	2.00e-72	264.00
IUUC-Meu-056565	Macropus eugenii	73.71	2.00e-87	314.00
IUUC-Mga-060153	Meleagris gallopavo	99.03	1.00e-107	381.00
IUUC-Mmr-061365	Microcebus murinus	72.96	5.00e-72	263.00
IUUC-Mdo-062824	Monodelphis domestica	73.83	6.00e-87	312.00
IUUC-Mmu-064120	Mus musculus	71.70	6.00e-71	259.00
IUUC-Mpu-066839	Mustela putorius furo	72.96	5.00e-72	263.00
IUUC-Mlu-067829	Myotis lucifugus	71.07	2.00e-70	258.00
IUUC-Nle-069592	Nomascus leucogenys	61.54	8.00e-70	255.00
IUUC-Ont-072173	Oreochromis niloticus	47.83	2.00e-38	151.00
IUUC-Ocu-073996	Oryctolagus cuniculus	72.96	2.00e-71	261.00
IUUC-Ola-087158	Oryzias latipes	49.69	3.00e-40	157.00
IUUC-Oga-088076	Otolemur garnettii	62.26	3.00e-73	267.00
IUUC-Ptr-091241	Pan troglodytes	61.14	2.00e-72	264.00
IUUC-Pan-091836	Papio anubis	62.32	9.00e-75	272.00
IUUC-Psi-093628	Pelodiscus sinensis	87.44	1.00e-106	377.00
IUUC-Pfo-097501	Poecilia formosa	42.01	4.00e-36	144.00
IUUC-Pab-098170	Pongo abelii	72.96	4.00e-72	263.00
IUUC-Pop-100072	Populus trichocarpa	30.61	2.20e-01	29.30
IUUC-Pva-102796	Pteropus vampyrus	72.33	1.00e-71	261.00
IUUC-Pgr-103356	Puccinia graminis	25.24	6.60e-01	28.10
IUUC-Rno-105319	Rattus norvegicus	71.70	6.00e-71	259.00
IUUC-Sha-107201	Sarcophilus harrisii	83.77	6.00e-77	278.00
IUUC-Ssc-116004	Sus scrofa	60.45	2.00e-74	271.00
IUUC-Tgu-116836	Taeniopygia guttata	93.24	3.00e-112	396.00
IUUC-Tru-118090	Takifugu rubripes	45.83	7.00e-37	146.00
IUUC-Tni-120719	Tetraodon nigroviridis	47.20	9.00e-33	132.00
IUUC-Vpa-130235	Vicugna pacos	72.96	5.00e-72	263.00
IUUC-Xtr-132610	Xenopus tropicalis	66.82	2.00e-78	284.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence