iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098369

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01137611

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000011482.1	ENSPPYT00000013335.1	ENSPPYP00000012819.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.90e-10	40.9	335	377

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
            C vCg+g++    +++C++C  +fH++C+ ++   ++p+   + C++C+
   Q: 335  RCGVCGDGTD----VLRCTHCAAAFHWRCHFPA-GASQPTG--LRCRSCS 377
           7********9....9******************.*******..9*****7 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAADAALRRF LRLHRTEIAV AVDSAFPLLH ALADHDVVPE DKFQETLHLK EKEGCPQAFH 60
ALLSWLLTQD STAILDFWRV LFKDYNLERY GRLQPILDSF PKDVDLSHPR KGRKPPAVPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCCG ACGCGGCGCT ACGCCGGTTC CTGAGGCTGC ACCGCACGGA GATCGCGGTG 60
GCCGTGGACA GCGCCTTCCC ACTGCTGCAC GCGCTGGCGG ACCACGACGT GGTCCCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND

Pfam

PF03172--HSR
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	83.63	3.00e-134	471.00
IUUC-Aca-004543	Anolis carolinensis	70.97	4.00e-25	105.00
IUUC-Bta-012988	Bos taurus	80.17	4.00e-138	484.00
IUUC-Cja-019486	Callithrix jacchus	78.79	3.00e-51	195.00
IUUC-Cfa-021069	Canis familiaris	81.76	1.00e-127	450.00
IUUC-Cpo-021649	Cavia porcellus	77.40	1.00e-124	440.00
IUUC-Csa-023960	Chlorocebus sabaeus	90.46	3.00e-135	475.00
IUUC-Dre-028583	Danio rerio	39.53	2.00e-52	200.00
IUUC-Dno-029869	Dasypus novemcinctus	66.85	1.00e-92	333.00
IUUC-Dor-030263	Dipodomys ordii	85.11	4.00e-45	174.00
IUUC-Ete-032778	Echinops telfairi	90.91	3.00e-55	209.00
IUUC-Eca-034328	Equus caballus	83.58	4.00e-145	508.00
IUUC-Fca-035400	Felis catus	80.94	4.00e-139	488.00
IUUC-Fal-036644	Ficedula albicollis	51.48	1.00e-70	260.00
IUUC-Ggo-045250	Gorilla gorilla	92.40	2.00e-135	475.00
IUUC-Hsa-046603	Homo sapiens	92.15	4.00e-134	471.00
IUUC-Itr-048977	Ictidomys tridecemlineatus	82.18	7.00e-127	447.00
IUUC-Lch-050310	Latimeria chalumnae	48.72	2.00e-82	299.00
IUUC-Loc-052508	Lepisosteus oculatus	46.78	7.00e-73	268.00
IUUC-Laf-054028	Loxodonta africana	79.65	6.00e-124	437.00
IUUC-Mcc-054935	Macaca mulatta	89.85	1.00e-139	489.00
IUUC-Mga-059318	Meleagris gallopavo	41.83	2.00e-52	199.00
IUUC-Mmr-061557	Microcebus murinus	67.05	3.00e-98	352.00
IUUC-Mdo-062475	Monodelphis domestica	58.53	3.00e-91	328.00
IUUC-Mmu-063994	Mus musculus	76.29	4.00e-135	474.00
IUUC-Mpu-066347	Mustela putorius furo	79.20	9.00e-144	503.00
IUUC-Mlu-068239	Myotis lucifugus	76.51	3.00e-42	165.00
IUUC-Nle-069544	Nomascus leucogenys	66.13	9.00e-17	80.10
IUUC-Opr-071199	Ochotona princeps	76.36	9.00e-78	284.00
IUUC-Ont-072571	Oreochromis niloticus	31.70	3.00e-32	132.00
IUUC-Oan-073739	Ornithorhynchus anatinus	64.72	3.00e-115	408.00
IUUC-Ola-086528	Oryzias latipes	34.24	2.00e-35	144.00
IUUC-Oga-088353	Otolemur garnettii	83.03	4.00e-139	488.00
IUUC-Oar-090065	Ovis aries	77.38	2.00e-132	465.00
IUUC-Ptr-091347	Pan troglodytes	92.40	8.00e-125	440.00
IUUC-Pan-092423	Papio anubis	88.26	5.00e-137	481.00
IUUC-Psi-093798	Pelodiscus sinensis	60.53	8.00e-97	347.00
IUUC-Pfo-096145	Poecilia formosa	43.62	5.00e-20	92.40
IUUC-Pca-100537	Procavia capensis	78.65	3.00e-126	445.00
IUUC-Pva-102639	Pteropus vampyrus	80.41	7.00e-123	434.00
IUUC-Rno-105285	Rattus norvegicus	76.60	1.00e-126	446.00
IUUC-Sha-107159	Sarcophilus harrisii	56.43	4.00e-91	328.00
IUUC-Ssc-115773	Sus scrofa	76.37	4.00e-124	438.00
IUUC-Tgu-116922	Taeniopygia guttata	48.82	5.00e-67	247.00
IUUC-Tru-118263	Takifugu rubripes	31.09	6.00e-37	148.00
IUUC-Tsy-119270	Tarsius syrichta	73.58	2.00e-96	346.00
IUUC-Tni-120138	Tetraodon nigroviridis	31.50	1.00e-40	160.00
IUUC-Tbe-128077	Tupaia belangeri	82.09	6.00e-121	427.00
IUUC-Ttr-128781	Tursiops truncatus	79.35	3.00e-77	282.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence