iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003963

Ensembl Protein ID

ENSAPLP00000015131.1

UniProt Accession

U3J6K4; U3J6K4_ANAPL

Genbank Protein ID

ENSAPLP00000015131

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

ADON01127510

Gene Name

RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000015285.1	ENSAPLT00000015923.1	ENSAPLP00000015131.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.70e-06	26.1	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iC+e f + p++lpC+H+ + +C+         +++ +  CP Cr
   Q: 16   CQICMEIFVE-PVTLPCNHTLCNSCFqLT------VENASLCCPFCR 55
           9********9.9**************444......5**********8 PP

Organism

Anas platyrhynchos

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSKKSEAPLS LADCLCQICM EIFVEPVTLP CNHTLCNSCF QLTVENASLC CPFCRRRVSS 60
WARYNARRNT LINWEFWEKI QKNYPKECER RINGQDLEEM VQKAQPQHQL SKPGELRQEY 120

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Nucleotide Sequence
(Fasta)

ATGTCGAAGA AATCGGAGGC TCCTCTTTCC TTAGCTGACT GCCTGTGTCA AATTTGCATG 60
GAGATCTTTG TGGAGCCTGT GACACTACCG TGCAACCATA CCCTCTGTAA TTCTTGTTTC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	34.21	2.00e-09	56.20
IUUC-Aml-001573	Ailuropoda melanoleuca	45.04	8.00e-77	280.00
IUUC-Aca-004420	Anolis carolinensis	45.80	3.00e-72	265.00
IUUC-Ame-011521	Astyanax mexicanus	47.62	5.00e-43	168.00
IUUC-Bta-013002	Bos taurus	43.75	1.00e-75	277.00
IUUC-Cja-019945	Callithrix jacchus	42.50	1.00e-72	266.00
IUUC-Cfa-020533	Canis familiaris	43.04	5.00e-75	275.00
IUUC-Cpo-021643	Cavia porcellus	41.45	1.00e-57	217.00
IUUC-Csa-023638	Chlorocebus sabaeus	44.69	3.00e-75	275.00
IUUC-Cho-024319	Choloepus hoffmanni	41.11	2.00e-65	243.00
IUUC-Cin-025679	Ciona intestinalis	36.89	1.00e-22	99.80
IUUC-Csv-026052	Ciona savignyi	35.42	1.00e-23	102.00
IUUC-Dre-028519	Danio rerio	44.74	7.00e-39	154.00
IUUC-Dno-029294	Dasypus novemcinctus	46.36	1.00e-76	280.00
IUUC-Ete-032714	Echinops telfairi	63.25	2.00e-41	162.00
IUUC-Eca-033343	Equus caballus	46.63	2.00e-79	290.00
IUUC-Fca-036251	Felis catus	46.85	1.00e-79	290.00
IUUC-Fal-037048	Ficedula albicollis	64.79	2.00e-160	558.00
IUUC-Gmo-039400	Gadus morhua	49.57	2.00e-35	140.00
IUUC-Gga-040444	Gallus gallus	74.24	0.00e+00	693.00
IUUC-Gac-041735	Gasterosteus aculeatus	53.57	2.00e-39	155.00
IUUC-Gma-044332	Glycine max	35.53	1.00e-10	60.50
IUUC-Ggo-044940	Gorilla gorilla	35.92	1.00e-23	103.00
IUUC-Hsa-046424	Homo sapiens	43.38	6.00e-71	261.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	44.86	2.00e-67	249.00
IUUC-Lch-050649	Latimeria chalumnae	41.37	7.00e-57	214.00
IUUC-Loc-051847	Lepisosteus oculatus	36.86	6.00e-52	197.00
IUUC-Laf-053938	Loxodonta africana	43.04	4.00e-79	288.00
IUUC-Mcc-055360	Macaca mulatta	41.28	5.00e-68	251.00
IUUC-Meu-056684	Macropus eugenii	40.55	1.00e-60	227.00
IUUC-Mtr-058007	Medicago truncatula	35.53	3.00e-10	58.90
IUUC-Mga-059699	Meleagris gallopavo	77.67	0.00e+00	705.00
IUUC-Mmr-060779	Microcebus murinus	45.42	9.00e-82	297.00
IUUC-Mdo-062225	Monodelphis domestica	44.85	3.00e-69	255.00
IUUC-Mmu-064239	Mus musculus	40.83	1.00e-63	236.00
IUUC-Mpu-066141	Mustela putorius furo	47.78	4.00e-86	311.00
IUUC-Mlu-067945	Myotis lucifugus	46.67	3.00e-76	279.00
IUUC-Nle-069769	Nomascus leucogenys	42.47	4.00e-69	255.00
IUUC-Opr-070905	Ochotona princeps	40.30	1.00e-60	227.00
IUUC-Ont-071477	Oreochromis niloticus	51.75	1.00e-38	153.00
IUUC-Oan-073587	Ornithorhynchus anatinus	70.87	1.00e-52	197.00
IUUC-Ocu-073832	Oryctolagus cuniculus	42.91	4.00e-66	245.00
IUUC-Ola-086478	Oryzias latipes	52.80	3.00e-36	143.00
IUUC-Oga-088318	Otolemur garnettii	45.93	2.00e-76	279.00
IUUC-Oar-089647	Ovis aries	43.41	1.00e-75	277.00
IUUC-Ptr-090516	Pan troglodytes	43.38	1.00e-73	270.00
IUUC-Pan-092302	Papio anubis	40.98	9.00e-67	247.00
IUUC-Psi-093604	Pelodiscus sinensis	54.13	1.00e-118	420.00
IUUC-Pfo-096441	Poecilia formosa	54.23	1.00e-44	173.00
IUUC-Pab-097729	Pongo abelii	43.01	3.00e-73	269.00
IUUC-Pca-100552	Procavia capensis	68.00	2.00e-40	160.00
IUUC-Pva-102780	Pteropus vampyrus	43.35	7.00e-74	271.00
IUUC-Rno-105461	Rattus norvegicus	41.61	2.00e-73	270.00
IUUC-Sha-106809	Sarcophilus harrisii	44.99	6.00e-75	274.00
IUUC-Sly-110934	Solanum lycopersicum	36.59	7.00e-12	64.30
IUUC-Stu-112446	Solanum tuberosum	36.59	6.00e-12	64.70
IUUC-Sar-113579	Sorex araneus	40.64	4.00e-57	215.00
IUUC-Sbi-113834	Sorghum bicolor	36.84	4.00e-10	58.50
IUUC-Tgu-117187	Taeniopygia guttata	80.09	1.00e-84	305.00
IUUC-Tru-118182	Takifugu rubripes	52.45	1.00e-36	147.00
IUUC-Tni-120205	Tetraodon nigroviridis	55.40	6.00e-45	174.00
IUUC-Tca-121416	Theobroma cacao	33.33	2.00e-10	59.70
IUUC-Tvi-122557	Trichoderma virens	30.43	6.00e-05	42.00
IUUC-Tae-123092	Triticum aestivum	34.21	2.00e-09	56.20
IUUC-Tbe-127622	Tupaia belangeri	45.50	4.00e-83	301.00
IUUC-Ttr-128988	Tursiops truncatus	45.49	2.00e-75	276.00
IUUC-Vpa-130302	Vicugna pacos	65.87	3.00e-48	186.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence