iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136918.7	ENST00000373574.1	ENSP00000362677.1
ENSG00000136918.7	ENST00000613760.4	ENSP00000483312.1
ENSG00000136918.7	ENST00000618744.4	ENSP00000483432.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
RepTar	miRcode	RAID2
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.20e-50	166.2	190	224
UBD/Beta-Prp	5.20e-68	231.1	15	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgv 34
           gH++ ++cl++  s +ll+sGs+D+ti++W ++t  
   Q: 190  GHSANISCLCYsaS-GLLASGSWDKTIHIWKPTTSS 224
           8**********754.****************99876 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           +++g+h + +++ +fspd+++l+tgs+dg++  w++++g+ll++l gh+++v+ ++fspdg +++++s D t+++wd+   kc+++lkgh++
   Q: 15   KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQR 106
           67899*************************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktg 169
           sv ++sfsp++  l+sG++d+ +++wd+++gq l+ +l gh++++++  ++p+ n+l++Gs D+tv +Wdl++ 
   Q: 107  SVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR-LLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
           ***********************************.***********************************985 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET RSGQLLWRLG 60
GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV LKGHQRSVET VSFSPDSRQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCCGATTA CCATGGAGAC CGCCTGTACA CAGTTTCCTC TTTCCTCTGC CCAGTCCTGG 60
GGTCCCGCGG CCGCCTAGGA GGGAGCCCGC CGGGGCGGGG CGGGGCCGGG TGCCCATGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001664	Ailuropoda melanoleuca	81.99	5.00e-150	523.00
IUUC-Ame-010858	Astyanax mexicanus	48.65	3.00e-75	275.00
IUUC-Bta-012352	Bos taurus	79.80	2.00e-138	484.00
IUUC-Cja-019585	Callithrix jacchus	88.22	5.00e-164	570.00
IUUC-Cfa-020062	Canis familiaris	77.51	2.00e-123	434.00
IUUC-Csa-023528	Chlorocebus sabaeus	95.87	8.00e-178	615.00
IUUC-Cin-025426	Ciona intestinalis	35.48	3.00e-51	195.00
IUUC-Dre-027740	Danio rerio	50.51	1.00e-49	189.00
IUUC-Dno-030012	Dasypus novemcinctus	71.04	1.00e-130	459.00
IUUC-Dor-030536	Dipodomys ordii	66.67	2.00e-103	369.00
IUUC-Ete-032871	Echinops telfairi	80.69	2.00e-105	374.00
IUUC-Eca-033729	Equus caballus	82.83	1.00e-144	505.00
IUUC-Eeu-034740	Erinaceus europaeus	76.85	6.00e-137	480.00
IUUC-Fca-036514	Felis catus	81.53	3.00e-149	520.00
IUUC-Ggo-044793	Gorilla gorilla	94.92	1.00e-174	605.00
IUUC-Itr-048798	Ictidomys tridecemlineatus	79.39	5.00e-125	440.00
IUUC-Lch-049905	Latimeria chalumnae	52.07	1.00e-87	316.00
IUUC-Loc-052101	Lepisosteus oculatus	52.11	1.00e-82	300.00
IUUC-Laf-053443	Loxodonta africana	78.00	1.00e-136	479.00
IUUC-Mcc-055346	Macaca mulatta	95.56	1.00e-177	615.00
IUUC-Meu-056531	Macropus eugenii	63.95	2.00e-81	295.00
IUUC-Mmr-061721	Microcebus murinus	84.51	3.00e-147	514.00
IUUC-Mdo-062379	Monodelphis domestica	64.16	7.00e-108	384.00
IUUC-Mmu-064175	Mus musculus	76.35	1.00e-129	456.00
IUUC-Mpu-066361	Mustela putorius furo	83.50	2.00e-145	508.00
IUUC-Mlu-067300	Myotis lucifugus	61.79	2.00e-94	338.00
IUUC-Nle-070150	Nomascus leucogenys	96.19	1.00e-169	588.00
IUUC-Opr-071060	Ochotona princeps	70.53	7.00e-112	396.00
IUUC-Ocu-074101	Oryctolagus cuniculus	80.25	3.00e-147	514.00
IUUC-Oga-088479	Otolemur garnettii	83.45	9.00e-144	502.00
IUUC-Oar-089608	Ovis aries	80.34	2.00e-138	485.00
IUUC-Ptr-091521	Pan troglodytes	98.41	0.00e+00	627.00
IUUC-Pan-092092	Papio anubis	95.24	3.00e-177	614.00
IUUC-Pab-098454	Pongo abelii	96.83	2.00e-178	617.00
IUUC-Pca-100981	Procavia capensis	80.57	8.00e-150	522.00
IUUC-Pva-102491	Pteropus vampyrus	79.62	2.00e-144	504.00
IUUC-Rno-105417	Rattus norvegicus	78.42	8.00e-126	442.00
IUUC-Sha-107649	Sarcophilus harrisii	64.60	6.00e-109	387.00
IUUC-Sar-113110	Sorex araneus	62.21	4.00e-80	291.00
IUUC-Ssc-116197	Sus scrofa	79.30	1.00e-144	506.00
IUUC-Tbe-127734	Tupaia belangeri	78.92	7.00e-74	270.00
IUUC-Ttr-128709	Tursiops truncatus	75.56	7.00e-136	476.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence