iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035908

Ensembl Protein ID

ENSFCAP00000011580.2

UniProt Accession

M3WH17; M3WH17_FELCA

Genbank Protein ID

ENSFCAP00000011580

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AANG02126172

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000012482.2	ENSFCAT00000012485.2	ENSFCAP00000011580.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.60e-19	69.0	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           6899**************************...**************************987 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKATLPMRN GSDVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGTA GCTGCAGCTC AAACCCTGAA GATGACTGGA TGGAAAACAT CGATGTGTGT 60
GAGAACTGCC ATTACCCGAT AGTCCCACTG GATGGCAAGG CCACGGTAAG AGGCAAGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0005102--F:receptor binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0006882--P:cellular zinc ion homeostasis
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

fca:101098805

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	94.06	0.00e+00	1045.00
IUUC-Apl-004134	Anas platyrhynchos	80.55	0.00e+00	733.00
IUUC-Bta-013264	Bos taurus	97.25	0.00e+00	1039.00
IUUC-Cja-019574	Callithrix jacchus	94.81	0.00e+00	711.00
IUUC-Cfa-021161	Canis familiaris	93.14	0.00e+00	1038.00
IUUC-Cpo-022492	Cavia porcellus	96.07	0.00e+00	1021.00
IUUC-Csa-023270	Chlorocebus sabaeus	78.19	0.00e+00	798.00
IUUC-Dre-028005	Danio rerio	75.00	0.00e+00	716.00
IUUC-Dno-029365	Dasypus novemcinctus	94.30	0.00e+00	995.00
IUUC-Dor-030892	Dipodomys ordii	92.03	0.00e+00	951.00
IUUC-Eca-033325	Equus caballus	96.27	0.00e+00	1013.00
IUUC-Eeu-035004	Erinaceus europaeus	88.66	0.00e+00	806.00
IUUC-Fal-036804	Ficedula albicollis	70.55	0.00e+00	727.00
IUUC-Gmo-038984	Gadus morhua	64.59	0.00e+00	698.00
IUUC-Gga-040997	Gallus gallus	82.32	0.00e+00	900.00
IUUC-Gac-041854	Gasterosteus aculeatus	68.82	0.00e+00	731.00
IUUC-Ggo-045238	Gorilla gorilla	92.39	0.00e+00	1026.00
IUUC-Hsa-047039	Homo sapiens	97.84	0.00e+00	1042.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	97.84	0.00e+00	1043.00
IUUC-Lch-049568	Latimeria chalumnae	77.34	0.00e+00	846.00
IUUC-Loc-052222	Lepisosteus oculatus	67.18	0.00e+00	673.00
IUUC-Laf-054499	Loxodonta africana	92.39	0.00e+00	1028.00
IUUC-Mcc-054872	Macaca mulatta	76.54	0.00e+00	844.00
IUUC-Meu-056879	Macropus eugenii	92.01	0.00e+00	986.00
IUUC-Mtr-058765	Medicago truncatula	33.66	1.00e-19	92.00
IUUC-Mga-059971	Meleagris gallopavo	81.73	0.00e+00	890.00
IUUC-Mmr-060740	Microcebus murinus	98.23	0.00e+00	1050.00
IUUC-Mdo-062192	Monodelphis domestica	93.32	0.00e+00	1001.00
IUUC-Mmu-064241	Mus musculus	96.66	0.00e+00	1036.00
IUUC-Mpu-066595	Mustela putorius furo	98.04	0.00e+00	1048.00
IUUC-Mlu-067069	Myotis lucifugus	96.47	0.00e+00	1030.00
IUUC-Opr-070472	Ochotona princeps	92.32	0.00e+00	1017.00
IUUC-Ont-071711	Oreochromis niloticus	68.63	0.00e+00	704.00
IUUC-Ocu-074221	Oryctolagus cuniculus	97.06	0.00e+00	1033.00
IUUC-Ola-087000	Oryzias latipes	68.50	0.00e+00	727.00
IUUC-Oga-088225	Otolemur garnettii	98.04	0.00e+00	1045.00
IUUC-Oar-090244	Ovis aries	85.69	0.00e+00	975.00
IUUC-Ptr-090751	Pan troglodytes	98.29	0.00e+00	721.00
IUUC-Pan-091804	Papio anubis	96.86	0.00e+00	1028.00
IUUC-Psi-093252	Pelodiscus sinensis	75.10	0.00e+00	802.00
IUUC-Pfo-096542	Poecilia formosa	67.89	0.00e+00	730.00
IUUC-Pab-098168	Pongo abelii	97.33	0.00e+00	988.00
IUUC-Pca-100547	Procavia capensis	96.26	0.00e+00	649.00
IUUC-Ppe-101646	Prunus persica	34.23	9.00e-23	102.00
IUUC-Rno-105542	Rattus norvegicus	96.46	0.00e+00	1035.00
IUUC-Sha-107524	Sarcophilus harrisii	92.53	0.00e+00	997.00
IUUC-Sar-113235	Sorex araneus	90.02	0.00e+00	868.00
IUUC-Ssc-115624	Sus scrofa	98.04	0.00e+00	1046.00
IUUC-Tru-118559	Takifugu rubripes	67.25	0.00e+00	726.00
IUUC-Ttr-129002	Tursiops truncatus	87.94	0.00e+00	965.00
IUUC-Xtr-132224	Xenopus tropicalis	76.03	0.00e+00	832.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence