iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000001579.1	ENSONIT00000001975.1	ENSONIP00000001976.1
ENSONIG00000001579.1	ENSONIT00000001976.1	ENSONIP00000001977.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.70e-116	388.4	699	1443

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++  ++ ++n +np ++ g+l+ s++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 699  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrAFEAEINCTNPLGTGGRLAISFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 785
           7******************************999***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d +   de     a++++k++n+s+i+dlFqgq+ks+++c++c +vs +++p
   Q: 786  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGR--LDEvvaeeAWQRHKMRNDSFIVDLFQGQFKSKLVCPTCSKVSITFDP 870
           ********************************999932..22235666*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++                                                                          
   Q: 871  FLYLPVPLPQKQKVLSVfyfakephkkpikflvsvskessstaevlesisrsvrvkpenlrlaevgknrfqrmflpthsldtvsssd 957
           ************76444********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 958  mlfcfevlskdlakervvllkvqqklqvpnipiskcaaclkppvseedklkrctrcyrvgycnqvcqrthwpnhkslcrpntenvgl 1044
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1045 pflvsvpesrlsysrlvqllegysrfsvnvfqppfqsgrtspetsqsrvdlppvpagspdledeavggsstvgagnleleshaslpe 1131
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1132 sqaeyaqasaihsgdseslsssqtslsttrttdsgfseslssasccfldphaeketscekavrpeaavagyqhpcesasghasqfyi 1218
           *************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenk 205
                                                                              +l++cL+ ftk+e l  e++
   Q: 1219 alldannkeqrlderedaladipddatlelvwknnerlkeyvlvsskeleyeedpgslsetaraghfTLEQCLNLFTKPEVLAPEEA 1305
           *************************************************************************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGsls 291
           +yc+kc++++ea+k+l l++lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++++ +++ +Y+L+av++H+G++ 
   Q: 1306 WYCPKCQQHREASKQLLLWRLPNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRnLDLSKFCIGQKDEMQQPPIYDLYAVINHYGGMI 1391
           *************************************8886.**********9********************************** PP
   S: 292  sGHYvayvknekgk........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +GHY+ay++  ++k        W lfdDs+Vt v+e++v++   + aYvlfY+rr
   Q: 1392 GGHYTAYARLPSDKnsqrsdvgWRLFDDSTVTMVDESQVVT---RYAYVLFYRRR 1443
           *********9444444567788*******************...********996 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MASSGSSGVA GSEAVGHRSG AQQRGGSGRE NGSDLPSSTS KKKQKDRANQ ESREAKRAAA 60
AAAAAVDGVI AEVKKDVFVD WKQNVNEVTV RLCCGEGVQR IEDINTTFTD THCNVDFPDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGAGAGA TCACGTGAGC ATGTCAGCCA GGAAGTGACC GTGCAATCGT TTCAGGTTTG 60
GCCGGTCAGC GCTGTAATTT CCTCCAAACA AAGTAGGATT CGCCCTGCAG AGGCCGGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	66.98	0.00e+00	1383.00
IUUC-Apl-003368	Anas platyrhynchos	70.88	0.00e+00	1409.00
IUUC-Aca-004267	Anolis carolinensis	70.88	0.00e+00	1434.00
IUUC-Ame-010970	Astyanax mexicanus	65.26	0.00e+00	1718.00
IUUC-Bta-012905	Bos taurus	67.53	0.00e+00	1379.00
IUUC-Cja-018789	Callithrix jacchus	69.98	0.00e+00	1388.00
IUUC-Cfa-021004	Canis familiaris	67.47	0.00e+00	1379.00
IUUC-Cpo-021529	Cavia porcellus	69.81	0.00e+00	1340.00
IUUC-Csa-024035	Chlorocebus sabaeus	68.35	0.00e+00	1409.00
IUUC-Cho-025036	Choloepus hoffmanni	71.03	0.00e+00	642.00
IUUC-Cin-025451	Ciona intestinalis	41.95	7.00e-84	306.00
IUUC-Dre-028556	Danio rerio	64.54	0.00e+00	1703.00
IUUC-Dno-029240	Dasypus novemcinctus	67.96	0.00e+00	1287.00
IUUC-Dor-030495	Dipodomys ordii	66.93	0.00e+00	847.00
IUUC-Ete-032741	Echinops telfairi	68.26	0.00e+00	1368.00
IUUC-Eca-033661	Equus caballus	69.25	0.00e+00	1382.00
IUUC-Eeu-034648	Erinaceus europaeus	73.68	1.00e-168	587.00
IUUC-Fca-035646	Felis catus	67.50	0.00e+00	1368.00
IUUC-Fal-037094	Ficedula albicollis	70.78	0.00e+00	1443.00
IUUC-Gmo-038869	Gadus morhua	75.05	0.00e+00	1507.00
IUUC-Gga-041170	Gallus gallus	70.12	0.00e+00	1415.00
IUUC-Gac-041901	Gasterosteus aculeatus	83.23	0.00e+00	1729.00
IUUC-Ggo-044708	Gorilla gorilla	70.01	0.00e+00	1379.00
IUUC-Hsa-046791	Homo sapiens	70.11	0.00e+00	1379.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	68.69	0.00e+00	1315.00
IUUC-Lch-050456	Latimeria chalumnae	68.18	0.00e+00	1110.00
IUUC-Loc-052861	Lepisosteus oculatus	56.37	0.00e+00	1453.00
IUUC-Laf-053788	Loxodonta africana	69.64	0.00e+00	1365.00
IUUC-Mcc-055693	Macaca mulatta	68.16	0.00e+00	1403.00
IUUC-Meu-055921	Macropus eugenii	69.89	0.00e+00	1186.00
IUUC-Mga-059879	Meleagris gallopavo	69.98	0.00e+00	1409.00
IUUC-Mmr-060802	Microcebus murinus	69.25	0.00e+00	1362.00
IUUC-Mdo-061856	Monodelphis domestica	70.02	0.00e+00	1345.00
IUUC-Mmu-063874	Mus musculus	69.28	0.00e+00	1376.00
IUUC-Mpu-066166	Mustela putorius furo	75.12	0.00e+00	941.00
IUUC-Nle-070161	Nomascus leucogenys	68.06	0.00e+00	1387.00
IUUC-Opr-071015	Ochotona princeps	68.22	0.00e+00	1341.00
IUUC-Oan-072723	Ornithorhynchus anatinus	68.93	0.00e+00	1376.00
IUUC-Ocu-073938	Oryctolagus cuniculus	68.54	0.00e+00	1377.00
IUUC-Ola-086375	Oryzias latipes	81.07	0.00e+00	1881.00
IUUC-Oga-088297	Otolemur garnettii	69.31	0.00e+00	1362.00
IUUC-Oar-089675	Ovis aries	63.52	0.00e+00	1218.00
IUUC-Ptr-091621	Pan troglodytes	70.12	0.00e+00	1375.00
IUUC-Pan-092118	Papio anubis	68.35	0.00e+00	1411.00
IUUC-Pma-094154	Petromyzon marinus	51.67	1.00e-115	410.00
IUUC-Pfo-097246	Poecilia formosa	81.82	0.00e+00	1852.00
IUUC-Pab-098551	Pongo abelii	69.40	0.00e+00	1362.00
IUUC-Pca-100158	Procavia capensis	66.80	0.00e+00	1303.00
IUUC-Pva-103160	Pteropus vampyrus	69.74	0.00e+00	1350.00
IUUC-Rno-105355	Rattus norvegicus	68.94	0.00e+00	1354.00
IUUC-Sha-107057	Sarcophilus harrisii	69.30	0.00e+00	1406.00
IUUC-Sar-113011	Sorex araneus	64.47	0.00e+00	992.00
IUUC-Ssc-115761	Sus scrofa	67.94	0.00e+00	1381.00
IUUC-Tgu-116956	Taeniopygia guttata	60.76	0.00e+00	762.00
IUUC-Tru-118739	Takifugu rubripes	77.00	0.00e+00	1821.00
IUUC-Tsy-118827	Tarsius syrichta	77.63	0.00e+00	691.00
IUUC-Tni-119921	Tetraodon nigroviridis	78.98	0.00e+00	1673.00
IUUC-Tbe-128017	Tupaia belangeri	67.95	0.00e+00	1323.00
IUUC-Ttr-128869	Tursiops truncatus	69.44	0.00e+00	1344.00
IUUC-Vpa-130427	Vicugna pacos	61.13	2.00e-171	597.00
IUUC-Xtr-132734	Xenopus tropicalis	70.48	0.00e+00	1392.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence