iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062258

Ensembl Protein ID

ENSMODP00000023122.2

UniProt Accession

F7GD33; F7GD33_MONDO

Protein Name

Uncharacterized protein

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018540.3	ENSMODT00000023535.3	ENSMODP00000023122.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.60e-47	159.4	192	251

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly+++++nd+eL+++kG++++viek e+d +W+k+ ++ +g+ Gl+P+n+v+ ++
   Q: 192  LHVVQALYPFSSSNDEELNFEKGEIMDVIEKPENDPEWWKC-RKINGQVGLVPKNYVTVMQ 251
           689**************************************.59*************9765 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNRTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKHSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCCCCGC CTAGGTACAA GCCAGGAGGG AGGTTGCAAT TTGAACAGCC AAGGTCAGTG 60
TTGCAACTAC TGGGGAGGAG GGGGAATGAA TGCCTAAAGG AACAGGCAGA GCCAGCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

KEGG

mdo:100016740

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	95.23	0.00e+00	717.00
IUUC-Ame-011235	Astyanax mexicanus	79.68	0.00e+00	634.00
IUUC-Bta-013039	Bos taurus	94.96	0.00e+00	712.00
IUUC-Cel-018144	Caenorhabditis elegans	42.05	1.00e-76	280.00
IUUC-Cja-019546	Callithrix jacchus	94.69	0.00e+00	709.00
IUUC-Cfa-020462	Canis familiaris	95.23	0.00e+00	717.00
IUUC-Cpo-022009	Cavia porcellus	93.63	0.00e+00	709.00
IUUC-Csa-023875	Chlorocebus sabaeus	94.96	0.00e+00	713.00
IUUC-Cho-024368	Choloepus hoffmanni	92.44	1.00e-180	625.00
IUUC-Csv-026046	Ciona savignyi	40.35	1.00e-72	266.00
IUUC-Dre-028407	Danio rerio	77.57	1.00e-179	622.00
IUUC-Dno-029593	Dasypus novemcinctus	93.93	4.00e-167	580.00
IUUC-Dor-030730	Dipodomys ordii	93.29	3.00e-178	617.00
IUUC-Dme-031846	Drosophila melanogaster	43.56	1.00e-91	330.00
IUUC-Ete-032906	Echinops telfairi	93.63	0.00e+00	703.00
IUUC-Eca-033378	Equus caballus	94.22	8.00e-178	615.00
IUUC-Eeu-034743	Erinaceus europaeus	84.08	0.00e+00	649.00
IUUC-Fca-035745	Felis catus	94.43	0.00e+00	750.00
IUUC-Gac-042245	Gasterosteus aculeatus	76.09	2.00e-160	558.00
IUUC-Ggo-045487	Gorilla gorilla	94.96	0.00e+00	713.00
IUUC-Hsa-045902	Homo sapiens	94.96	0.00e+00	713.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	94.69	0.00e+00	714.00
IUUC-Lch-050165	Latimeria chalumnae	83.55	0.00e+00	634.00
IUUC-Loc-052523	Lepisosteus oculatus	80.47	0.00e+00	634.00
IUUC-Laf-053845	Loxodonta africana	93.90	0.00e+00	709.00
IUUC-Meu-056139	Macropus eugenii	95.23	0.00e+00	692.00
IUUC-Mla-058934	Melampsora laricipopulina	44.26	2.00e-07	50.40
IUUC-Mmr-061108	Microcebus murinus	83.02	5.00e-168	583.00
IUUC-Mmu-063970	Mus musculus	93.90	0.00e+00	748.00
IUUC-Mpu-066093	Mustela putorius furo	94.69	0.00e+00	714.00
IUUC-Mlu-067193	Myotis lucifugus	94.43	0.00e+00	710.00
IUUC-Nle-069611	Nomascus leucogenys	94.96	0.00e+00	713.00
IUUC-Opr-070984	Ochotona princeps	92.03	1.00e-170	592.00
IUUC-Ont-072241	Oreochromis niloticus	76.15	5.00e-172	597.00
IUUC-Oan-072976	Ornithorhynchus anatinus	89.58	6.00e-168	583.00
IUUC-Ocu-073905	Oryctolagus cuniculus	94.43	0.00e+00	712.00
IUUC-Ola-086513	Oryzias latipes	76.15	4.00e-162	563.00
IUUC-Oga-088588	Otolemur garnettii	94.43	0.00e+00	711.00
IUUC-Oar-089973	Ovis aries	95.23	0.00e+00	714.00
IUUC-Ptr-090968	Pan troglodytes	94.96	0.00e+00	713.00
IUUC-Pan-092840	Papio anubis	94.57	3.00e-168	583.00
IUUC-Pfo-096057	Poecilia formosa	75.00	1.00e-170	592.00
IUUC-Pab-097807	Pongo abelii	95.23	0.00e+00	714.00
IUUC-Pca-100522	Procavia capensis	93.29	1.00e-166	578.00
IUUC-Pva-103083	Pteropus vampyrus	94.69	0.00e+00	712.00
IUUC-Rno-104839	Rattus norvegicus	91.51	0.00e+00	712.00
IUUC-Sha-107294	Sarcophilus harrisii	97.88	0.00e+00	733.00
IUUC-Sar-113675	Sorex araneus	93.90	0.00e+00	704.00
IUUC-Ssc-116442	Sus scrofa	94.43	0.00e+00	753.00
IUUC-Tru-118058	Takifugu rubripes	74.81	2.00e-169	588.00
IUUC-Tsy-119184	Tarsius syrichta	86.94	1.00e-174	605.00
IUUC-Tni-119974	Tetraodon nigroviridis	75.00	1.00e-158	552.00
IUUC-Ttr-129155	Tursiops truncatus	92.31	0.00e+00	706.00
IUUC-Vpa-130344	Vicugna pacos	94.96	0.00e+00	714.00
IUUC-Xtr-132372	Xenopus tropicalis	88.03	0.00e+00	665.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence