iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	18485060

Classification

Family	E-value	Score	Start	End
DUB/USP	4.20e-78	263.8	443	747

Active Site

Position(s)	Description	Evidence
447	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092}
703	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           Gl N gN+CY N+vLQ+L+ +++l  +ll+ +++++++     +++ +l+++l++ +  l  ++ +  s +++l+++++++ ++   +q+Da+Efl+ 
   Q: 443  GLVNCGNSCYANAVLQSLTCTKPLVAYLLRrSHSRSCS-----GKDWCLMCELEQHVMML-RESGGPLSASRILSHMRSINCQIGDGSQEDAHEFLRL 534
           9*****************************44455554.....6678**********766.9999********************************* PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           l+ ++++ +                ++l  e + ++  ++++l++++F+g+l+s++kcl+cd++s+r+e+ +dl+l++ g  e    slqd+L +ft+
   Q: 535  LVASMQSIC---------------LERLGGETKVDPRLQETTLVQHMFGGRLRSKVKCLRCDHESERYENIMDLTLEIYGWVE----SLQDALTQFTR 613
           *********...............22344556788999******************************************996....8********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsGsls... 291
           +e l+gen+y c++c ++++a+k+l++++ P++L++ LkRf    ++++  kink+++fp++Ld+ pf+t++  ++  +  Y L+av+vH  +l+   
   Q: 614  PEDLDGENMYRCSRCAGYVRARKELSIHEAPNILTIVLKRF----QEGRYGKINKCISFPEMLDMIPFMTRTG-DV--PPLYMLYAVIVHLDTLNasf 704
           *****************************************....458889********************44.44..9***********99766445 PP
   S: 292  sGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           sGHY++yvk+ +g+W+++dDs++++v++++v +   + aY+lfY+r
   Q: 705  SGHYISYVKDLRGNWYRIDDSEIHPVPMTQVMS---EGAYMLFYMR 747
           8********************************...********98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MLEPRGADIP ILFLVLVVLP VVAYILLGKW SNISEKRVRA NLLAQMAAEE ALRAETVVNA 60
DRGVRFESVA TENRAQRTRT KTVSAGGGAV RAEFDAGARE TVAEQRSDSV TATCGVTVVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGGTTAA TTATTAGTTT ATTTAAAAAC AGCATCCTGA AGGACGGAGA GAGACAGAGT 60
ATGCGAGGAG TGTGAAAACG AAGAGCATAA ACAACACGGG ACGAGGAGAG AGAAACTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS00972--USP_1
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G17110

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000426	Aegilops tauschii	69.63	3.00e-141	494.00
IUUC-Atr-003062	Amborella trichopoda	55.69	5.00e-151	527.00
IUUC-Aly-006034	Arabidopsis lyrata	92.94	0.00e+00	1649.00
IUUC-Bdi-014717	Brachypodium distachyon	69.58	5.00e-157	548.00
IUUC-Bol-015616	Brassica oleracea	81.59	0.00e+00	1444.00
IUUC-Bra-017955	Brassica rapa	82.26	0.00e+00	1471.00
IUUC-Gma-043603	Glycine max	47.89	0.00e+00	754.00
IUUC-Lpe-051615	Leersia perrieri	66.75	6.00e-153	534.00
IUUC-Mtr-058164	Medicago truncatula	48.82	0.00e+00	744.00
IUUC-Mac-065271	Musa acuminata	64.88	1.00e-167	582.00
IUUC-Opr-071170	Ochotona princeps	42.70	5.00e-59	222.00
IUUC-Oba-075960	Oryza barthii	59.33	1.00e-155	543.00
IUUC-Obr-076330	Oryza brachyantha	69.23	1.00e-159	556.00
IUUC-Ogl-077370	Oryza glaberrima	67.43	9.00e-160	556.00
IUUC-Ogu-078615	Oryza glumaepatula	59.29	8.00e-156	543.00
IUUC-Oin-079409	Oryza indica	67.43	2.00e-160	558.00
IUUC-Olo-080550	Oryza longistaminata	59.29	3.00e-156	545.00
IUUC-Ome-081508	Oryza meridionalis	59.56	8.00e-156	543.00
IUUC-Oni-082740	Oryza nivara	59.29	1.00e-155	543.00
IUUC-Opu-083669	Oryza punctata	66.08	4.00e-137	481.00
IUUC-Oru-084502	Oryza rufipogon	59.29	1.00e-155	543.00
IUUC-Osa-085475	Oryza sativa	67.43	9.00e-160	556.00
IUUC-Olu-087767	Ostreococcus lucimarinus	38.66	9.00e-61	226.00
IUUC-Pop-099882	Populus trichocarpa	53.05	0.00e+00	793.00
IUUC-Ppe-101942	Prunus persica	49.46	0.00e+00	796.00
IUUC-Sit-109825	Setaria italica	58.65	2.00e-160	558.00
IUUC-Sly-111027	Solanum lycopersicum	57.30	0.00e+00	679.00
IUUC-Sbi-114225	Sorghum bicolor	58.37	6.00e-162	564.00
IUUC-Tca-121618	Theobroma cacao	49.43	0.00e+00	814.00
IUUC-Tae-123144	Triticum aestivum	69.60	3.00e-145	508.00
IUUC-Tur-126234	Triticum urartu	66.76	3.00e-154	538.00
IUUC-Vvi-131600	Vitis vinifera	50.06	0.00e+00	790.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence