iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.30e-52	177.0	224	554

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaee.fsg 86
           +Gl+N+ +  Y N+vLQ+Lsn+p+lr+++le+++ k  ++ p +    l++ + +l+++lw   + k +vsp+e+l+a+  ++++ f+ 
   Q: 224  VGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWnpRNFKAHVSPHEMLQAVVLCSKKtFQI 312
           6*********************************9999***********************999999**************99999*** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk................sqikclec 159
           ++q D  +fl+++l++l+++l                          +kkk+k++++d+Fqg+++                +q+  +e 
   Q: 313  TKQGDGVDFLSWFLNALHSAL------------------------GGTKKKKKTIVNDVFQGSMRiftkklphpdlpaeekEQLLHNEE 377
           *********************........................457888888888888888888888888888888888******** PP
   S: 160  dnvssreepfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsf 239
            +++  e++f++l+l++p     k e          l ++L++f    e e    y++ k     +  k+++l+klP++Li+ +kRf  
   Q: 378  YQETMVESTFMYLTLDLPTAPLYKDEkeqliipqvPLFNILAKFNGITEKE----YKTYK----ENFLKRFQLTKLPPYLIFCIKRF-- 456
           ******************877776664455566666666666666666655....44333....3489*******************.. PP
   S: 240  seeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleet 326
           ++++ + ek+ + v+fp++ +dl+++++++ ++++++++Y+Lia +vH G++s+G Y  +v +  +gkW+++ D +Vt +  + +    
   Q: 457  TKNNFFVEKNPTIVNFPITnVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHhGTGKWYELQDLQVTDILPQMITL-- 543
           88889********************************************************9935666******************9.. PP
   S: 327  gstaYvlfYkrr 338
            s+aY+ ++krr
   Q: 544  -SEAYIQIWKRR 554
           .********985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSSRSKRQSH GSTRGKRESE SRGSSGRIKK ERDREKEPEA ASSRGSPVRV KREAEPTPRE 60
VPAPVLPVVR VKREREADED SEPEREVRAK NGRVDSEDRR SRHCPYLDTI NRSVLDFDFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTGATTAA CTGGAGGATG AAGAGCATGG AGTGTGGCAG ACCCTCCTTC ACCCCGAAGG 60
CTCTGGATGG TATCTAACCA AGTAAGGCCA CAGGCACTTT CAGCACTAGT GCACAAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033809--USP39
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0000245--P:spliceosomal complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000483	Aegilops tauschii	53.15	7.00e-128	450.00
IUUC-Aml-001846	Ailuropoda melanoleuca	96.81	0.00e+00	1056.00
IUUC-Atr-002758	Amborella trichopoda	51.50	5.00e-128	451.00
IUUC-Apl-003336	Anas platyrhynchos	91.32	3.00e-175	607.00
IUUC-Aca-004846	Anolis carolinensis	97.15	0.00e+00	903.00
IUUC-Aly-005683	Arabidopsis lyrata	50.76	6.00e-117	414.00
IUUC-Ath-007661	Arabidopsis thaliana	50.33	5.00e-116	411.00
IUUC-Ago-007802	Ashbya gossypii	30.85	2.00e-60	226.00
IUUC-Acl-008304	Aspergillus clavatus	41.63	9.00e-92	330.00
IUUC-Afl-008735	Aspergillus flavus	58.12	1.00e-40	160.00
IUUC-Afu-009100	Aspergillus fumigatus	40.67	1.00e-89	323.00
IUUC-Ani-009138	Aspergillus nidulans	49.14	1.00e-94	340.00
IUUC-Ang-009661	Aspergillus niger	44.83	4.00e-95	342.00
IUUC-Aor-010235	Aspergillus oryzae	38.77	3.00e-79	289.00
IUUC-Ate-010346	Aspergillus terreus	36.52	7.00e-72	265.00
IUUC-Ame-011688	Astyanax mexicanus	89.25	0.00e+00	842.00
IUUC-Bgr-011998	Blumeria graminis	48.03	3.00e-115	408.00
IUUC-Bta-013407	Bos taurus	96.81	0.00e+00	1014.00
IUUC-Bci-013977	Botrytis cinerea	48.91	1.00e-114	407.00
IUUC-Bdi-014361	Brachypodium distachyon	53.35	9.00e-135	473.00
IUUC-Bol-016317	Brassica oleracea	50.22	3.00e-115	408.00
IUUC-Bra-017952	Brassica rapa	50.66	4.00e-116	411.00
IUUC-Cel-018491	Caenorhabditis elegans	62.39	2.00e-177	615.00
IUUC-Cja-019134	Callithrix jacchus	97.54	0.00e+00	1053.00
IUUC-Cfa-020098	Canis familiaris	97.72	0.00e+00	1053.00
IUUC-Cpo-021595	Cavia porcellus	99.18	0.00e+00	993.00
IUUC-Cre-022886	Chlamydomonas reinhardtii	50.81	2.00e-31	127.00
IUUC-Csa-024121	Chlorocebus sabaeus	97.69	0.00e+00	1035.00
IUUC-Cho-025057	Choloepus hoffmanni	77.34	4.00e-86	311.00
IUUC-Cin-025473	Ciona intestinalis	62.50	2.00e-64	238.00
IUUC-Csv-025815	Ciona savignyi	81.62	2.00e-117	416.00
IUUC-Cgl-026416	Colletotrichum gloeosporioides	44.49	6.00e-109	387.00
IUUC-Cne-026802	Cryptococcus neoformans	43.17	5.00e-100	358.00
IUUC-Dre-027870	Danio rerio	88.87	0.00e+00	836.00
IUUC-Dno-029655	Dasypus novemcinctus	93.01	0.00e+00	1036.00
IUUC-Dor-030762	Dipodomys ordii	94.87	0.00e+00	1007.00
IUUC-Dse-031441	Dothistroma septosporum	45.38	7.00e-107	380.00
IUUC-Dme-032101	Drosophila melanogaster	64.92	4.00e-180	624.00
IUUC-Ete-032841	Echinops telfairi	92.79	0.00e+00	981.00
IUUC-Eca-033463	Equus caballus	99.60	0.00e+00	1013.00
IUUC-Eeu-034438	Erinaceus europaeus	71.72	0.00e+00	736.00
IUUC-Fca-035774	Felis catus	97.56	0.00e+00	1063.00
IUUC-Fal-036988	Ficedula albicollis	92.65	0.00e+00	912.00
IUUC-Fox-037895	Fusarium oxysporum	45.36	2.00e-104	373.00
IUUC-Fso-038450	Fusarium solani	46.44	8.00e-106	377.00
IUUC-Gmo-038874	Gadus morhua	87.69	0.00e+00	821.00
IUUC-Ggr-040115	Gaeumannomyces graminis	43.04	4.00e-103	368.00
IUUC-Gac-041650	Gasterosteus aculeatus	85.92	0.00e+00	850.00
IUUC-Gma-043697	Glycine max	50.64	7.00e-128	451.00
IUUC-Ggo-044707	Gorilla gorilla	90.62	0.00e+00	1012.00
IUUC-Hsa-046041	Homo sapiens	97.88	0.00e+00	1037.00
IUUC-Hvu-047816	Hordeum vulgare	50.22	5.00e-122	431.00
IUUC-Itr-048945	Ictidomys tridecemlineatus	99.12	0.00e+00	685.00
IUUC-Lch-050419	Latimeria chalumnae	92.08	0.00e+00	897.00
IUUC-Lpe-051593	Leersia perrieri	54.01	5.00e-134	471.00
IUUC-Loc-052930	Lepisosteus oculatus	86.23	0.00e+00	857.00
IUUC-Lma-053256	Leptosphaeria maculans	47.84	5.00e-112	398.00
IUUC-Laf-053555	Loxodonta africana	99.20	0.00e+00	1011.00
IUUC-Mcc-055630	Macaca mulatta	97.69	0.00e+00	1035.00
IUUC-Meu-056579	Macropus eugenii	94.44	2.00e-179	622.00
IUUC-Mor-057078	Magnaporthe oryzae	44.03	3.00e-103	369.00
IUUC-Mpo-057607	Magnaporthe poae	37.65	3.00e-84	305.00
IUUC-Mtr-058644	Medicago truncatula	49.36	2.00e-127	449.00
IUUC-Mla-059120	Melampsora laricipopulina	40.88	4.00e-101	362.00
IUUC-Mvi-060429	Microbotryum violaceum	46.33	3.00e-68	253.00
IUUC-Mmr-061313	Microcebus murinus	95.68	0.00e+00	1024.00
IUUC-Mdo-062801	Monodelphis domestica	90.97	0.00e+00	1036.00
IUUC-Mmu-064424	Mus musculus	99.29	0.00e+00	1052.00
IUUC-Mac-064694	Musa acuminata	52.55	3.00e-130	458.00
IUUC-Mpu-065980	Mustela putorius furo	99.52	0.00e+00	854.00
IUUC-Mlu-067007	Myotis lucifugus	93.13	0.00e+00	1036.00
IUUC-Nfi-068274	Neosartorya fischeri	39.23	1.00e-89	324.00
IUUC-Ncr-068829	Neurospora crassa	48.07	2.00e-106	379.00
IUUC-Nle-069171	Nomascus leucogenys	99.58	0.00e+00	971.00
IUUC-Opr-070494	Ochotona princeps	88.95	0.00e+00	905.00
IUUC-Ont-072290	Oreochromis niloticus	85.43	0.00e+00	867.00
IUUC-Oan-073099	Ornithorhynchus anatinus	96.86	0.00e+00	953.00
IUUC-Ocu-074642	Oryctolagus cuniculus	99.19	0.00e+00	1008.00
IUUC-Oba-075886	Oryza barthii	53.36	2.00e-133	468.00
IUUC-Obr-076220	Oryza brachyantha	53.36	2.00e-133	469.00
IUUC-Ogl-077682	Oryza glaberrima	53.36	1.00e-133	469.00
IUUC-Ogu-078492	Oryza glumaepatula	53.15	2.00e-133	469.00
IUUC-Oin-079956	Oryza indica	53.36	2.00e-133	469.00
IUUC-Olo-080239	Oryza longistaminata	46.93	4.00e-105	376.00
IUUC-Ome-081573	Oryza meridionalis	53.36	7.00e-134	470.00
IUUC-Oni-082975	Oryza nivara	53.36	2.00e-133	469.00
IUUC-Opu-083724	Oryza punctata	53.58	1.00e-133	469.00
IUUC-Oru-084566	Oryza rufipogon	53.36	1.00e-133	469.00
IUUC-Osa-086008	Oryza sativa	53.36	1.00e-133	470.00
IUUC-Ola-086967	Oryzias latipes	89.40	0.00e+00	849.00
IUUC-Olu-087614	Ostreococcus lucimarinus	44.13	1.00e-96	347.00
IUUC-Oga-088047	Otolemur garnettii	80.09	0.00e+00	660.00
IUUC-Oar-089393	Ovis aries	98.07	0.00e+00	1039.00
IUUC-Ptr-090561	Pan troglodytes	97.88	0.00e+00	1038.00
IUUC-Pan-091812	Papio anubis	97.50	0.00e+00	1032.00
IUUC-Psi-093507	Pelodiscus sinensis	98.65	1.00e-170	592.00
IUUC-Pno-095104	Phaeosphaeria nodorum	46.61	1.00e-109	390.00
IUUC-Ppa-095995	Physcomitrella patens	51.53	7.00e-134	470.00
IUUC-Pfo-096754	Poecilia formosa	89.01	0.00e+00	863.00
IUUC-Pab-098053	Pongo abelii	97.88	0.00e+00	1038.00
IUUC-Pop-099230	Populus trichocarpa	47.71	1.00e-134	473.00
IUUC-Pca-100407	Procavia capensis	90.93	0.00e+00	908.00
IUUC-Ppe-101699	Prunus persica	52.39	3.00e-128	452.00
IUUC-Pva-103159	Pteropus vampyrus	93.98	0.00e+00	1062.00
IUUC-Pgr-103433	Puccinia graminis	42.62	1.00e-103	370.00
IUUC-Ptt-103701	Puccinia triticina	39.44	2.00e-91	329.00
IUUC-Pte-104281	Pyrenophora teres	43.07	7.00e-112	397.00
IUUC-Pyt-104714	Pyrenophora triticirepentis	47.39	1.00e-111	397.00
IUUC-Sce-106368	Saccharomyces cerevisiae	29.75	3.00e-47	182.00
IUUC-Sha-107093	Sarcophilus harrisii	96.82	0.00e+00	999.00
IUUC-Sja-108004	Schizosaccharomyces japonicus	41.84	6.00e-115	407.00
IUUC-Spo-108018	Schizosaccharomyces pombe	46.83	7.00e-113	400.00
IUUC-Ssl-108460	Sclerotinia sclerotiorum	46.44	3.00e-106	379.00
IUUC-Smo-108892	Selaginella moellendorffii	51.51	7.00e-131	460.00
IUUC-Sit-110782	Setaria italica	52.22	4.00e-136	478.00
IUUC-Sly-111308	Solanum lycopersicum	52.16	4.00e-138	484.00
IUUC-Stu-112447	Solanum tuberosum	53.70	4.00e-137	481.00
IUUC-Sar-113352	Sorex araneus	78.23	0.00e+00	800.00
IUUC-Sbi-114806	Sorghum bicolor	54.74	1.00e-135	476.00
IUUC-Sre-115059	Sporisorium reilianum	53.57	4.00e-72	265.00
IUUC-Ssc-115677	Sus scrofa	94.95	0.00e+00	746.00
IUUC-Tru-118478	Takifugu rubripes	86.58	0.00e+00	862.00
IUUC-Tsy-119082	Tarsius syrichta	86.19	0.00e+00	733.00
IUUC-Tni-120419	Tetraodon nigroviridis	86.01	0.00e+00	840.00
IUUC-Tca-121294	Theobroma cacao	51.17	1.00e-134	473.00
IUUC-Tre-121962	Trichoderma reesei	46.24	3.00e-102	365.00
IUUC-Tvi-122280	Trichoderma virens	45.91	2.00e-109	389.00
IUUC-Tae-125873	Triticum aestivum	54.21	2.00e-134	472.00
IUUC-Tur-126551	Triticum urartu	54.21	7.00e-134	470.00
IUUC-Tme-126959	Tuber melanosporum	47.62	3.00e-113	402.00
IUUC-Tbe-127737	Tupaia belangeri	90.53	0.00e+00	945.00
IUUC-Ttr-129211	Tursiops truncatus	96.90	8.00e-170	590.00
IUUC-Uma-129591	Ustilago maydis	39.35	5.00e-96	345.00
IUUC-Vda-129674	Verticillium dahliae	44.09	6.00e-95	341.00
IUUC-Vpa-130793	Vicugna pacos	83.33	0.00e+00	889.00
IUUC-Xtr-132430	Xenopus tropicalis	90.10	0.00e+00	893.00
IUUC-Xma-133515	Xiphophorus maculatus	88.86	0.00e+00	852.00
IUUC-Yli-134488	Yarrowia lipolytica	38.63	1.00e-79	290.00
IUUC-Zma-134748	Zea mays	53.22	2.00e-135	476.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence