iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021331

Ensembl Protein ID

ENSCPOP00000007137.2

UniProt Accession

H0VB70; H0VB70_CAVPO

Genbank Protein ID

ENSCPOP00000007137

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAKN02022919

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000007928.3	ENSCPOT00000008003.2	ENSCPOP00000007137.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.60e-14	53.1	1528	1568

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1528 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1568
           8*********....*******************....99996.******8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MDQTCELSRR NCLLRFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STASGTPQNA 60
YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQSP IVCTSLSPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCAGA CCTGTGAACT ATCTAGAAGA AATTGTCTGC TGCGCTTTTC CAATCCAGTG 60
AATTTAGATG CCCCTGAAGA CAAGGACAGC CCTTTCGGTA ATGGTCAATC CAATTTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001795	Ailuropoda melanoleuca	88.44	0.00e+00	2716.00
IUUC-Apl-003953	Anas platyrhynchos	62.21	0.00e+00	1620.00
IUUC-Aca-005339	Anolis carolinensis	58.60	0.00e+00	1486.00
IUUC-Bta-012966	Bos taurus	87.81	0.00e+00	2749.00
IUUC-Bol-016001	Brassica oleracea	29.35	1.00e-15	79.30
IUUC-Bra-017864	Brassica rapa	28.80	2.00e-14	75.90
IUUC-Cja-018780	Callithrix jacchus	89.48	0.00e+00	2445.00
IUUC-Cfa-020975	Canis familiaris	87.81	0.00e+00	2701.00
IUUC-Csa-024226	Chlorocebus sabaeus	88.89	0.00e+00	2711.00
IUUC-Cho-024464	Choloepus hoffmanni	81.83	0.00e+00	1044.00
IUUC-Dre-028152	Danio rerio	62.69	0.00e+00	1238.00
IUUC-Dno-029230	Dasypus novemcinctus	84.14	0.00e+00	2518.00
IUUC-Dor-031016	Dipodomys ordii	82.24	0.00e+00	1319.00
IUUC-Dme-032193	Drosophila melanogaster	39.47	7.00e-118	419.00
IUUC-Eca-033591	Equus caballus	87.55	0.00e+00	2689.00
IUUC-Fca-035791	Felis catus	88.19	0.00e+00	2741.00
IUUC-Fal-037378	Ficedula albicollis	69.46	0.00e+00	1545.00
IUUC-Gmo-038919	Gadus morhua	70.92	0.00e+00	923.00
IUUC-Gga-040881	Gallus gallus	70.10	0.00e+00	1550.00
IUUC-Gac-041378	Gasterosteus aculeatus	77.87	0.00e+00	1065.00
IUUC-Hsa-046436	Homo sapiens	89.07	0.00e+00	2714.00
IUUC-Hvu-047760	Hordeum vulgare	40.98	1.00e-09	59.70
IUUC-Itr-048194	Ictidomys tridecemlineatus	89.71	0.00e+00	2789.00
IUUC-Lch-049684	Latimeria chalumnae	66.54	0.00e+00	1346.00
IUUC-Lpe-051661	Leersia perrieri	28.72	9.00e-12	66.20
IUUC-Laf-054046	Loxodonta africana	87.03	0.00e+00	2702.00
IUUC-Mcc-055593	Macaca mulatta	88.83	0.00e+00	2712.00
IUUC-Mga-059756	Meleagris gallopavo	64.30	0.00e+00	1614.00
IUUC-Mmr-061182	Microcebus murinus	88.76	0.00e+00	2725.00
IUUC-Mdo-061984	Monodelphis domestica	69.80	0.00e+00	2083.00
IUUC-Mmu-063605	Mus musculus	84.32	0.00e+00	2587.00
IUUC-Mpu-066446	Mustela putorius furo	87.88	0.00e+00	2740.00
IUUC-Mlu-067261	Myotis lucifugus	86.86	0.00e+00	2625.00
IUUC-Nle-069818	Nomascus leucogenys	88.63	0.00e+00	2699.00
IUUC-Opr-070842	Ochotona princeps	82.71	0.00e+00	2288.00
IUUC-Ont-072448	Oreochromis niloticus	74.26	0.00e+00	1122.00
IUUC-Oan-073496	Ornithorhynchus anatinus	71.87	0.00e+00	1618.00
IUUC-Ocu-074918	Oryctolagus cuniculus	88.89	0.00e+00	2786.00
IUUC-Obr-076753	Oryza brachyantha	54.84	9.00e-08	53.50
IUUC-Oin-079426	Oryza indica	44.44	6.00e-11	64.30
IUUC-Ola-087518	Oryzias latipes	75.28	0.00e+00	1033.00
IUUC-Oga-088743	Otolemur garnettii	87.39	0.00e+00	2686.00
IUUC-Oar-090265	Ovis aries	87.68	0.00e+00	2742.00
IUUC-Ptr-090521	Pan troglodytes	89.26	0.00e+00	2727.00
IUUC-Psi-093245	Pelodiscus sinensis	72.02	0.00e+00	1531.00
IUUC-Pfo-096066	Poecilia formosa	75.97	0.00e+00	1186.00
IUUC-Pab-098644	Pongo abelii	88.56	0.00e+00	2699.00
IUUC-Pva-103094	Pteropus vampyrus	89.16	0.00e+00	1797.00
IUUC-Rno-105803	Rattus norvegicus	84.96	0.00e+00	2621.00
IUUC-Sha-107278	Sarcophilus harrisii	70.72	0.00e+00	2090.00
IUUC-Sar-113402	Sorex araneus	79.40	0.00e+00	1487.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	4.00e-13	66.60
IUUC-Ssc-116193	Sus scrofa	87.56	0.00e+00	2618.00
IUUC-Tgu-116532	Taeniopygia guttata	89.11	0.00e+00	1234.00
IUUC-Tru-117988	Takifugu rubripes	77.64	0.00e+00	1185.00
IUUC-Tsy-118830	Tarsius syrichta	88.82	0.00e+00	2256.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence