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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064293
Ensembl Protein ID ENSMUSP00000099638.4
UniProt Accession Q80UP5; Q2VPQ7; Q6P7F2; AN13A_MOUSE
Genbank Protein ID AAH49187.1; AAH61692.1; AAI08414.1
Protein Name Ankyrin repeat domain-containing protein 13A
Genbank Nucleotide ID BC049187; BC061692; BC108413
Gene Name Ankrd13a; Ankrd13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041870.16 ENSMUST00000137519.1 ENSMUSP00000116994.1
ENSMUSG00000041870.16 ENSMUST00000102578.10 ENSMUSP00000099638.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UIM 90.50 0.00e+00 1062.00 IUUC-Hsa-046361
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).
 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).
Protein Sequence
(Fasta)
MSSARDTSSR FPLHLLVWNN DYEQLEKELR DQNAEALDPR GRTLLHLAVS LGHLESARVL 60
LRHKADVTKE NGQGWTVLHE AVSTGDPEMV YTVLQHRDYH NTSMALEGVP ELLHKILEAP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064293|UBD,UIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGGCCCGA TTGTGGAGCG CACCACTGGA AGAGGCTGGG CAGGGGACGA GAGTCGCGGG 60
GCGCGCATCG TGGACTTTGT GCGTGGAGAT CTCGGGCTTC TCGGAGGCCC TGCGGTCCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064293|UBD,UIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR021832--ANKRD13
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR003903--UIM_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM
Pfam

PF11904--GPCR_chapero_1
SMART

SM00248--ANK
SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005770--C:late endosome
GO:0005886--C:plasma membrane
KEGG mmu:68420
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003583 Anas platyrhynchos 73.12 0.00e+00 810.00
IUUC-Ame-011766 Astyanax mexicanus 61.42 0.00e+00 677.00
IUUC-Bta-012454 Bos taurus 90.68 0.00e+00 1008.00
IUUC-Cel-018411 Caenorhabditis elegans 34.71 3.00e-96 346.00
IUUC-Cja-019299 Callithrix jacchus 89.73 0.00e+00 1035.00
IUUC-Cfa-020519 Canis familiaris 91.19 0.00e+00 1061.00
IUUC-Cpo-022361 Cavia porcellus 92.88 0.00e+00 1092.00
IUUC-Csa-023720 Chlorocebus sabaeus 90.50 0.00e+00 1041.00
IUUC-Cho-025017 Choloepus hoffmanni 87.28 0.00e+00 1007.00
IUUC-Dre-028557 Danio rerio 62.60 0.00e+00 702.00
IUUC-Dno-029547 Dasypus novemcinctus 89.85 0.00e+00 962.00
IUUC-Dor-030905 Dipodomys ordii 86.87 0.00e+00 978.00
IUUC-Ete-032445 Echinops telfairi 85.25 0.00e+00 955.00
IUUC-Eca-034374 Equus caballus 90.44 0.00e+00 1069.00
IUUC-Fca-035872 Felis catus 90.54 0.00e+00 1033.00
IUUC-Fal-037420 Ficedula albicollis 72.08 0.00e+00 816.00
IUUC-Gmo-039087 Gadus morhua 62.33 0.00e+00 697.00
IUUC-Gga-040676 Gallus gallus 71.46 0.00e+00 699.00
IUUC-Gac-042445 Gasterosteus aculeatus 61.01 0.00e+00 671.00
IUUC-Ggo-044701 Gorilla gorilla 90.09 0.00e+00 1032.00
IUUC-Hsa-046361 Homo sapiens 90.59 0.00e+00 1041.00
IUUC-Itr-048701 Ictidomys tridecemlineatus 91.48 0.00e+00 861.00
IUUC-Lch-050665 Latimeria chalumnae 68.89 1.00e-174 605.00
IUUC-Loc-052905 Lepisosteus oculatus 64.06 0.00e+00 714.00
IUUC-Laf-053531 Loxodonta africana 91.64 0.00e+00 1072.00
IUUC-Mcc-054987 Macaca mulatta 90.86 0.00e+00 1037.00
IUUC-Meu-056395 Macropus eugenii 88.89 0.00e+00 988.00
IUUC-Mga-059750 Meleagris gallopavo 73.48 0.00e+00 843.00
IUUC-Mmr-061570 Microcebus murinus 91.76 0.00e+00 1072.00
IUUC-Mdo-062680 Monodelphis domestica 86.97 0.00e+00 1016.00
IUUC-Mpu-066697 Mustela putorius furo 91.02 0.00e+00 1044.00
IUUC-Mlu-067506 Myotis lucifugus 90.32 0.00e+00 1065.00
IUUC-Nle-069249 Nomascus leucogenys 90.41 0.00e+00 1040.00
IUUC-Opr-070751 Ochotona princeps 91.68 0.00e+00 1053.00
IUUC-Ont-072652 Oreochromis niloticus 62.94 0.00e+00 699.00
IUUC-Oan-073637 Ornithorhynchus anatinus 85.66 0.00e+00 847.00
IUUC-Ocu-074568 Oryctolagus cuniculus 92.13 0.00e+00 1049.00
IUUC-Ola-087282 Oryzias latipes 65.30 0.00e+00 672.00
IUUC-Oga-089125 Otolemur garnettii 84.94 0.00e+00 977.00
IUUC-Oar-089947 Ovis aries 90.68 0.00e+00 1005.00
IUUC-Ptr-090995 Pan troglodytes 90.59 0.00e+00 1041.00
IUUC-Pan-091908 Papio anubis 90.21 0.00e+00 1029.00
IUUC-Psi-093017 Pelodiscus sinensis 72.99 0.00e+00 822.00
IUUC-Pfo-096285 Poecilia formosa 63.47 0.00e+00 706.00
IUUC-Pab-098541 Pongo abelii 90.59 0.00e+00 1041.00
IUUC-Pva-102946 Pteropus vampyrus 88.32 0.00e+00 972.00
IUUC-Ptt-103794 Puccinia triticina 42.50 3.50e-01 30.40
IUUC-Rno-105860 Rattus norvegicus 97.33 0.00e+00 1115.00
IUUC-Sha-106472 Sarcophilus harrisii 87.63 0.00e+00 977.00
IUUC-Sar-113275 Sorex araneus 77.40 0.00e+00 639.00
IUUC-Ssc-116021 Sus scrofa 93.59 0.00e+00 706.00
IUUC-Tgu-117508 Taeniopygia guttata 72.70 0.00e+00 838.00
IUUC-Tru-118161 Takifugu rubripes 62.15 0.00e+00 701.00
IUUC-Tsy-119511 Tarsius syrichta 87.63 0.00e+00 981.00
IUUC-Tni-120857 Tetraodon nigroviridis 60.57 0.00e+00 689.00
IUUC-Tbe-128109 Tupaia belangeri 93.71 0.00e+00 972.00
IUUC-Ttr-128175 Tursiops truncatus 85.97 0.00e+00 980.00
IUUC-Xtr-132267 Xenopus tropicalis 73.13 0.00e+00 837.00
Created Date 25-Jun-2017

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