iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071637

Ensembl Protein ID

ENSONIP00000022489.1

UniProt Accession

I3KMZ4; I3KMZ4_ORENI

Genbank Protein ID

ENSONIP00000022489

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AERX01019255

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000017839.1	ENSONIT00000022509.1	ENSONIP00000022489.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-98	329.6	285	682

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++ +re++l+                 ++                                       
   Q: 285  TGLRNLGNTCYMNSILQVLSHLHVFRECFLRldltqaleL-------LASavqgqlagkassqppliqrkglqtslgsgvglsggasra 366
           7******************************855433330.......333556667777778899999999999999999999999999 PP
   S: 43   ...........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeee 120
                      ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el++        + +
   Q: 367  rsmeliqpkepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWQLIPAFRGYAQQDAQEFLCELLDKVQHELES--------TGK 447
           9999999999999999************************************************************44........222 PP
   S: 121  edkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLesftkeeele 201
            ++s+   + +++  k+  s+++++F+gql  q++cl+cd++s++ epf+dlsl++p++ +++ +         l+++L++ft++e le
   Q: 448  HTTSAGVPQTQKRLIKQVLSVVNTIFHGQLLRQVTCLACDHRSNTVEPFWDLSLEFPERYHSNSResaaqascHLTEMLAKFTETEALE 536
           2233334456899999*****************************************9998766699999******************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g n y c++c++ ++           a+k+l+++klP+vL lhLkRf++s + ++reki  +v+f + L+++p+c+++ + +++  +  
   Q: 537  G-NIYACDQCNSARRrtsskpvilteAQKQLMVHKLPQVLRLHLKRFRWSGR-NHREKIGVHVSFDQLLNMEPYCCREPSPKARpkHFL 623
           9.77*******888888888888888***********************997.8889*********99********9666555445899 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           YeL+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ +ev++   ++aY+lfY++
   Q: 624  YELSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVDEVCR---AQAYILFYTQ 682
           *************************9999********************...********98 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

ACVMDRCKHV GRLRLAPDHS ILNPQKWHCV DCNTTESIWG CLGCAHVACG RYIEEHALQH 60
FQQQGHPLAM EVNELYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIQSQRY EVTTRSGRTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTGTGTAA TGGACAGGTG TAAGCATGTG GGGCGGCTGC GGCTGGCCCC AGACCACTCC 60
ATCCTTAACC CCCAGAAGTG GCACTGCGTT GACTGCAACA CCACCGAGTC CATATGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	64.66	0.00e+00	870.00
IUUC-Apl-003673	Anas platyrhynchos	69.48	0.00e+00	939.00
IUUC-Aca-004434	Anolis carolinensis	68.92	0.00e+00	913.00
IUUC-Ame-010986	Astyanax mexicanus	74.68	0.00e+00	973.00
IUUC-Bta-012774	Bos taurus	62.95	0.00e+00	878.00
IUUC-Cja-019619	Callithrix jacchus	63.61	0.00e+00	878.00
IUUC-Cfa-020957	Canis familiaris	64.33	0.00e+00	885.00
IUUC-Csa-023177	Chlorocebus sabaeus	63.81	0.00e+00	875.00
IUUC-Cin-025587	Ciona intestinalis	47.42	7.00e-107	382.00
IUUC-Csv-025814	Ciona savignyi	43.92	9.00e-147	514.00
IUUC-Dre-027878	Danio rerio	75.36	0.00e+00	935.00
IUUC-Dno-029832	Dasypus novemcinctus	64.31	0.00e+00	877.00
IUUC-Ete-032627	Echinops telfairi	63.44	0.00e+00	867.00
IUUC-Eca-033863	Equus caballus	64.24	0.00e+00	854.00
IUUC-Eeu-035225	Erinaceus europaeus	59.72	0.00e+00	824.00
IUUC-Fca-036288	Felis catus	64.21	0.00e+00	863.00
IUUC-Fal-037290	Ficedula albicollis	64.19	0.00e+00	769.00
IUUC-Gga-040457	Gallus gallus	70.22	0.00e+00	921.00
IUUC-Gac-042371	Gasterosteus aculeatus	82.02	0.00e+00	660.00
IUUC-Ggo-044926	Gorilla gorilla	64.23	0.00e+00	882.00
IUUC-Hsa-046079	Homo sapiens	64.23	0.00e+00	882.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	63.47	0.00e+00	884.00
IUUC-Lch-050260	Latimeria chalumnae	66.38	0.00e+00	872.00
IUUC-Loc-051981	Lepisosteus oculatus	78.84	0.00e+00	668.00
IUUC-Laf-054491	Loxodonta africana	61.60	0.00e+00	866.00
IUUC-Mcc-055694	Macaca mulatta	63.95	0.00e+00	874.00
IUUC-Mga-059523	Meleagris gallopavo	68.94	0.00e+00	926.00
IUUC-Mmr-060885	Microcebus murinus	64.94	0.00e+00	887.00
IUUC-Mdo-063018	Monodelphis domestica	69.44	0.00e+00	923.00
IUUC-Mmu-064095	Mus musculus	61.74	0.00e+00	793.00
IUUC-Mpu-066207	Mustela putorius furo	62.98	0.00e+00	879.00
IUUC-Mlu-066929	Myotis lucifugus	60.75	0.00e+00	828.00
IUUC-Nle-069486	Nomascus leucogenys	62.39	0.00e+00	787.00
IUUC-Opr-070375	Ochotona princeps	59.60	0.00e+00	806.00
IUUC-Oan-073030	Ornithorhynchus anatinus	66.22	0.00e+00	733.00
IUUC-Ocu-074836	Oryctolagus cuniculus	63.41	0.00e+00	847.00
IUUC-Oga-088367	Otolemur garnettii	64.52	0.00e+00	874.00
IUUC-Oar-089953	Ovis aries	63.09	0.00e+00	883.00
IUUC-Ptr-090980	Pan troglodytes	64.38	0.00e+00	885.00
IUUC-Pan-092748	Papio anubis	64.41	0.00e+00	880.00
IUUC-Pma-094155	Petromyzon marinus	59.03	7.00e-83	300.00
IUUC-Pfo-096860	Poecilia formosa	81.26	0.00e+00	1076.00
IUUC-Pab-098514	Pongo abelii	64.52	0.00e+00	887.00
IUUC-Pca-100449	Procavia capensis	60.91	0.00e+00	787.00
IUUC-Pva-102984	Pteropus vampyrus	63.47	0.00e+00	874.00
IUUC-Rno-105190	Rattus norvegicus	61.47	0.00e+00	788.00
IUUC-Sha-106965	Sarcophilus harrisii	69.05	0.00e+00	923.00
IUUC-Ssc-115299	Sus scrofa	64.41	0.00e+00	880.00
IUUC-Tgu-117160	Taeniopygia guttata	68.12	0.00e+00	918.00
IUUC-Tru-118156	Takifugu rubripes	86.72	0.00e+00	1107.00
IUUC-Tsy-118814	Tarsius syrichta	62.25	0.00e+00	783.00
IUUC-Tni-119733	Tetraodon nigroviridis	79.92	0.00e+00	1078.00
IUUC-Tbe-128084	Tupaia belangeri	60.52	0.00e+00	831.00
IUUC-Ttr-128928	Tursiops truncatus	63.71	0.00e+00	879.00
IUUC-Vpa-130706	Vicugna pacos	63.52	0.00e+00	881.00
IUUC-Xtr-132061	Xenopus tropicalis	69.50	0.00e+00	867.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence