iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041658

UUCD1 version

UUC-GaA-00229

Ensembl Protein ID

ENSGACP00000006257.1

UniProt Accession

G3NLP4; G3NLP4_GASAC

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000004740.1	ENSGACT00000006274.1	ENSGACP00000006257.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-136	453.4	531	863

Active Site

Position(s)	Description	Evidence
832	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 531  AQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDT 618
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl++ik+n   +iee+gl+l fsv++eilge++++eLkp+G + +Vt+eNkeeY++lv+e
   Q: 619  GFSLPFYKRILNKPLALKDLESIDPEFYNSLMWIKDN---NIEECGLELFFSVDKEILGEVSTHELKPDGGELQVTEENKEEYIRLVAE 704
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid+ d+++ t y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 705  WRMSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLVDWQRSTIYRH-YARNSKQIVWFWQFIKEMDNEKRMRLLQFV 792
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e++kekL++Aieet+gF++
   Q: 793  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQMKEKLMFAIEETEGFGQ 863
           *********************************************************************96 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MASGVTKTST PNGYPMKAQL QIVVLSAKLK ENRKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
HSPKWKQPLT VIVTPFSKLV FRVWSHQTLK SDVLLGMATL DVSDTLKSND MKIAEVVQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAAGTG GAGTCACCAA GACGAGCACT CCCAACGGTT ACCCCATGAA GGCTCAGCTA 60
CAAATCGTCG GTAAGTGTTC AGAGCTCTTC CCCTTTTCTC ACTTTACCGT TGTTACCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	82.39	0.00e+00	1112.00
IUUC-Apl-003752	Anas platyrhynchos	86.22	0.00e+00	1115.00
IUUC-Cpo-022073	Cavia porcellus	86.82	0.00e+00	1125.00
IUUC-Cho-024695	Choloepus hoffmanni	82.75	0.00e+00	1118.00
IUUC-Dre-028451	Danio rerio	79.40	0.00e+00	1399.00
IUUC-Dno-029884	Dasypus novemcinctus	72.47	0.00e+00	1298.00
IUUC-Fca-035605	Felis catus	75.26	0.00e+00	1307.00
IUUC-Fal-037126	Ficedula albicollis	86.94	0.00e+00	1115.00
IUUC-Gga-040832	Gallus gallus	85.69	0.00e+00	1116.00
IUUC-Hsa-046564	Homo sapiens	86.82	0.00e+00	1123.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	86.15	0.00e+00	1113.00
IUUC-Lch-050454	Latimeria chalumnae	73.86	0.00e+00	1321.00
IUUC-Laf-054383	Loxodonta africana	86.99	0.00e+00	1125.00
IUUC-Mga-059661	Meleagris gallopavo	85.86	0.00e+00	1117.00
IUUC-Mmr-061135	Microcebus murinus	86.99	0.00e+00	1126.00
IUUC-Mdo-062505	Monodelphis domestica	87.33	0.00e+00	1123.00
IUUC-Mmu-063375	Mus musculus	87.16	0.00e+00	1127.00
IUUC-Mpu-066203	Mustela putorius furo	82.23	0.00e+00	1111.00
IUUC-Mlu-067837	Myotis lucifugus	82.23	0.00e+00	1111.00
IUUC-Nle-069244	Nomascus leucogenys	86.32	0.00e+00	1114.00
IUUC-Opr-070585	Ochotona princeps	86.49	0.00e+00	1113.00
IUUC-Ocu-074298	Oryctolagus cuniculus	86.99	0.00e+00	1125.00
IUUC-Ola-086526	Oryzias latipes	89.92	0.00e+00	1162.00
IUUC-Oga-088167	Otolemur garnettii	68.93	0.00e+00	1199.00
IUUC-Ptr-090819	Pan troglodytes	85.81	0.00e+00	1086.00
IUUC-Pan-092454	Papio anubis	85.64	0.00e+00	1111.00
IUUC-Psi-093319	Pelodiscus sinensis	78.28	0.00e+00	1068.00
IUUC-Pfo-097346	Poecilia formosa	85.09	0.00e+00	1143.00
IUUC-Pca-100923	Procavia capensis	74.44	0.00e+00	982.00
IUUC-Pva-103209	Pteropus vampyrus	74.21	0.00e+00	1245.00
IUUC-Rno-104924	Rattus norvegicus	85.88	0.00e+00	1132.00
IUUC-Sha-107175	Sarcophilus harrisii	83.74	0.00e+00	1127.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	49.04	3.00e-157	548.00
IUUC-Tgu-116632	Taeniopygia guttata	82.41	0.00e+00	1025.00
IUUC-Tru-118442	Takifugu rubripes	89.54	0.00e+00	1189.00
IUUC-Tsy-119198	Tarsius syrichta	77.50	0.00e+00	984.00
IUUC-Vpa-130103	Vicugna pacos	74.66	0.00e+00	937.00
IUUC-Xtr-132885	Xenopus tropicalis	84.26	0.00e+00	1123.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence